1000 mg garcinia cambogia supplements with 60 hca reviews

1000 mg garcinia cambogia supplements with 60 hca reviews
Be careful not to go overboard though because you run the risk of voiding all the work done throughout the week.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

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Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice.

The garcinia fruit contains a chemical compound called Hydroxycitric acid (HCA).

16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia.

In the event that you are thinking about how quick this supplement could function, at that point you will be astounded to hear this astonishing recipe begins conveying you with observable advantages inside half a month as it were.

Preuss, HG, et al., Effects of a natural extract of (-)-hydroxycitric acid (CHA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss.

36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I.

Personally prefer the slower weight loss at 60 hca then 80 hca.

Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

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45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.

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Copyright © 2009 Wolters Kluwer Health

Garcinia Probably Works But Is Far From a Weight Loss Miracle

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Women make up a majority of Dr. Oz’s audience. The majority of women would like to lose weight. That is a match made in heaven, a marketer’s dream. And Oz has never hesitated to exploit that fact to increase audience share, playing fast and loose with sensationalized evidence instead of giving his viewers science-based advice.

Garcinia cambogia extract (GCE) comes from a tropical fruit from India and Southeast Asia.

Here are the views: “I dropped from 13.5% to 11% body fat in time for my beauty show.” “I have been taking for 2 weeks and have lost 8lbs, I love it!” “I have been taking Garcinia Cambogia for 2 months and have lost 10lbs.” “I have been taking it for two weeks and don’t see an extraordinary change, just 3lbs in two weeks.” “After 1 week, I was surprised by the dramatic results…my energy levels were up and I wasn’t even hungry…after the fifth week my results were shocking.

The active ingredient, hydroxycitric acid (HCA), is said to block fat and suppress the appetite.

Dr. Oz has promoted a series of weight loss supplements on his show. Raspberry ketones were presented as a fat-busting miracle, then green coffee bean extract was touted as “magic,” “staggering,” and “unprecedented.” And now both of those miracles have apparently been superseded by an even greater miracle: Garcinia cambogia extract.

Dr. Oz calls it “The newest, fastest fat buster.” A way to lose weight without “spending every waking moment exercising and dieting.” “Triples your weight loss.” “The most exciting breakthrough in natural weight loss to date.” “The Holy Grail.” Oz claims that “Revolutionary new research says it could be the magic ingredient that lets you lose weight without diet or exercise.”

All that sounds too good to be true, and it is. Garcinia probably does work to some extent to improve weight loss, but the evidence doesn’t begin to justify such grandiose claims.

Garcinia basics

Garcinia cambogia extract (GCE) comes from a tropical fruit grown in India and Southeast Asia. The active ingredient has been identified: hydroxycitric acid (HCA). It is said to block fat and suppress the appetite. It inhibits a key enzyme, citrate lyase, that the body needs to make fat from carbohydrates. It suppresses appetite by increasing serotonin levels; low serotonin levels are associated with depression and emotional or reactive eating.

It allegedly decreases belly fat, suppresses appetite, controls emotional eating, and changes body composition by increasing lean muscle mass. It doesn’t just produce weight loss, but it improves overall health. It is said to decrease cholesterol, LDL, and triglycerides by 10-30% and to raise levels of the “good cholesterol” HDL.

Quality concerns

An independent analysis found that some brands contain far less active ingredient than claimed. Consumers are advised to look for at least 50% GCE with potassium but with no fillers, binders, or artificial ingredients.

It should be taken on empty stomach 30-60 minutes before a meal. Results increase with dosage, but doses over 3 000 mg a day should be cleared with your doctor.

Oz’s advice

Dr. Oz recommends a dose of 500-1000 mg of Garcinia cambogia potassium before each meal. (Some experts believe the potassium salt is more effective than other formulations.) He says not to take it if you are pregnant or breastfeeding, or if you have Alzheimer’s disease or other forms of dementia, because it can worsen dementia. If you have diabetes, it can cause hypoglycemia, and if you are on a statin, it can increase the risk of harmful side effects like rhabdomyolysis or muscle degradation.

Oz contradicts himself: he suggests that it can produce weight loss without diet or exercise, yet he clearly recommends it be used along with exercise and properly portioned meals.

The garcinia evidence

With Dr. Oz’s track record, I was not willing to simply accept his word for the wonders of Garcinia. I went to PubMed, where a search for hydroxycitric acid brought up 64 articles. Some were irrelevant, and the relevant ones included a lot of animal studies and a smaller number of human studies with inconsistent results.

Guinea pigs on a high cholesterol diet who were given a different Garcinia species (atriviridis) had a tendency to decrease lipid composition levels and fat deposition in the aorta. HCA caused congenital defects in rats. Another rat study found that it decreased body weight gain and visceral fat accumulation by reducing food intake but had no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia. Yet another rat study showed that it suppressed body fat accumulation but was toxic to the testes.

To try to make sense of the inconsistent results, Onakpoya et al. did a systematic review of the published randomized controlled trials (RCTs) as of 2011. Their analysis found a small, statistically significant difference in weight loss (1.75 kg vs 0.88 kg, less than 2 pounds). They commented that the studies all had methodological weaknesses, so these results could be due to GIGO (garbage in/garbage out). The two studies with the best methodology found no statistically significant difference from placebo. Adverse events were twice as common with Garcinia (headache, nausea, upper respiratory and gastrointestinal symptoms). The authors concluded:

The evidence from RCTs suggests that Garcinia extracts/HCA generate weight loss on the short term. However, the magnitude of this effect is small, is no longer statistically significant when only rigorous RCTs are considered, and its clinical relevance seems questionable.

Oz featured a patient testimonial on the show from a woman who had lost 10 pounds in 4 months. She started noticing results after a week; she reported that her sugar cravings were decreased, she had more energy, and she went down a dress size from 10 to 8. She had no side effects. Says she was at a plateau and wanted a jump-start.

Garcinia verdict

At this point, I don’t think we can reliably say whether Garcinia has a clinically relevant advantage over simple calorie reduction and exercise. It appears to be safe, and it may have a role in helping patients lose weight by assisting motivation and enlisting placebo effects.

Dr. Oz’s popularity is enduring, but diet fads aren’t. I confidently expect another “miracle” to supplant Garcinia in the Land of Oz in the not-too-distant future.

  • Posted in: Herbs & Supplements, Science and the Media
  • Tagged in: garcinia, Mehmet Oz, The Dr. Oz Show, weight loss supplements

Posted by Harriet Hall

Harriet Hall, MD also known as The SkepDoc, is a retired family physician who writes about pseudoscience and questionable medical practices. She received her BA and MD from the University of Washington, did her internship in the Air Force (the second female ever to do so), and was the first female graduate of the Air Force family practice residency at Eglin Air Force Base.

FDA certified manufacturing process and FDA approved are two different things.

During a long career as an Air Force physician, she held various positions from flight surgeon to DBMS (Director of Base Medical Services) and did everything from delivering babies to taking the controls of a B-52. She retired with the rank of Colonel. In 2008 she published her memoirs, Women Aren't Supposed to Fly .

– Muscle & Fitness… Men's Supplements Reviews

KetoSlim: Everyone is always after a quick and easy method to lose weight. Therefore, there is always some diet program, some exercise, or worse, some remedy that people promise to burn calories quickly.

One such remedy is KetoSlim, a remedy based on Garcinia cambogia that is commonly used as an antidepressant. This antidepressant works by increasing production of serotonin in body, which is used to combat some psychological disorders.

Despite this specific use, some people consume this supplement to lose weight. But does it really work?

What is KetoSlim?

There is a huge amount of products that promise to help you in arduous task of losing weight. Among them is KetoSlim , a supplement that many say help to lose weight. Being a natural product, it draws even more attention from those who are trying to burn off excess calories in body.

In addition to helping you lose weight, it still brings promise of many other benefits to body. Despite this, many experts argue that it brings more benefits to health than no harm, which creates some controversy around it.

In addition to assisting in weight loss with no side effect, it has other benefits. One of them is ability to lower LDL cholesterol levels in blood, decreasing need for heavy and painful medications in body.

KetoSlim increases satiety feelings

Studies were conducted to evaluate influence of this supplement on body weight loss. Results indicate that KetoSlim can have a great influence on this, as it causes a greater sensation of satiety in body, making person consume fewer calories than normal.

Best part is that over course of studies, it has been realized that effects of this supplement on weight loss are influenced whether person taking supplement is dieting or not.

KetoSlim against anxiety and depression

Studies on how it works in fight against anxiety are not yet fully confirmed, but some effect has already been noted in humans. In first tests, it was possible to notice prevention against panic attacks in healthy people due to weight loss, for example.

Because it affects mood, it is highly expected that it will play a role in treatment of depression. Some research that is already underway confirms effects of KetoSlim to treat depression in mild and moderate stages.

Benefits of KetoSlim

Within these other benefits that it offers, we can cite many different effects in body. To begin with, it has effects that help to regulate cholesterol levels in body, increasing good cholesterol and lowering bad. Other benefits of KetoSlim are in controlling anxiety and preventing constipation.

As for its most aesthetic benefits, it still decreases incidence of cellulite, and also leaves skin soft and shiny. Finally, some of benefits of this supplement are those that help you lose weight by promoting a sense of satiety and decreasing appetite of those who consume it.

As stated above, KetoSlim brings about effects such as reduced appetite. That decreases amount of calories eaten and consequently helps you to lose weight. Of course, this is only this product that contributes to fat loss so fast.

To help with fat burning, it acts directly on localized fat. It prevents fat consumed with food from coming into contact with fatty tissue, causing our body to not accumulate fat, and releasing fat through stool.

Should you consume KetoSlim?

Because of lack of knowledge about Garcinia cambogia, most doctors and nutritionists refuse to recommend it to anyone who wants to lose weight. Although miraculous products like KetoSlim are quite flashy, best way to lose weight is always through a balanced diet and a healthy exercise routine.

It’s important to take care of your body and want to have a healthier lifestyle, but often KetoSlim “shortcut” we find along bring more benefits and no harm.

How KetoSlim works?

This supplement carries high doses of Garcinia cambogia, a component known as a natural weight loss miracle. It is a simple fruit, serves as a weight-loss aid supplement. It can be powerful tool for you to aid in weight loss.

This fruit is full of fibers. As a more powerful version of these fibers, it binds fat molecules in gut, preventing them from being absorbed by body. This causes fat to be eliminated from body.

Garcinia cambogia extract makes 60% portions of supplement help you lose weight at a high level. Obviously, it produces much more lasting effects if it is associated with a more balanced diet and exercise. In addition, it has better results when it is used in medium and long term in body.

KetoSlim Side effects

Despite being considered relatively safe and natural, KetoSlim, based on Garcinia cambogia, still offers some side effects to body. Among these effects is greater sensitivity of muscles.

In addition, cases of muscle problems such as burning can be observed. Other effects are nausea, vomiting, diarrhea, drowsiness, disturbances in libido, aggression and gas. In case any of these symptoms, or any other unlisted, are observed, you should contact your doctor immediately and discontinue treatment.

Fears against this supplement concern lack of studies on Garcinia cambogia. It means that we do not have enough information about its action to know whether it is effective or safe.

Because of this, there is no certain dosage indicated for consumption. So it is extremely important that you see a doctor if you are thinking of using this supplement to lose weight.