Effects of garcinia cambogia on fertility
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GARCINIA Overview Information
Garcinia is a small to medium-sized tree that grows in India and Southeast Asia. The fruit rind contains the chemical hydroxycitric acid (HCA) and is used to make medicine. Don't confuse Garcinia with Garcinia hanburyi (gamboge resin).
How does it work?
Garcinia contains the chemical hydroxycitric acid (HCA). Developing research suggests that HCA might prevent fat storage, control appetite, and increase exercise endurance; however, whether these effects occur in humans is unclear.
GARCINIA Uses & Effectiveness
Insufficient Evidence for:
- Exercise performance. Taking a chemical compound found in Garcinia called hydroxycitric acid (HCA) might increase how long untrained women are able to exercise. However, it does not seem benefit men in the same way.
- Weight loss. Research on the effect of Garcinia on weight loss is inconsistent. Some research shows that taking Garcinia extract that contains 50% hydroxycitric acid (HCA) for 8-12 weeks doesn't decrease fat breakdown or energy expenditure in overweight people. However, other research suggests that it might improve weight loss when taken for 12 weeks. Taking a specific Garcinia product containing 60% HCA (Super CitriMax InterHealth Nutriceuticals) by mouth in three doses daily 30 to 60 minutes before meals for 8 weeks, together with a healthy diet, seems to improve weight loss more than just diet alone. But other research shows that adding this specific Garcinia product to cereal bars or tomato juice and consuming them before lunch and dinner for 2 weeks does not improve weight loss. Reasons for the inconsistent results might be the dose, duration of treatment, or formulation of Garcinia extract that was used.
- Joint pain.
- Treating worms and parasites.
- Emptying the bowel.
- Severe diarrhea (dysentery).
- Other conditions.
GARCINIA Side Effects & Safety
Garcinia is POSSIBLY SAFE for most people when taken by mouth for 12 weeks or less. Long-term safety is unknown. Garcinia can cause nausea, digestive tract discomfort, and headache.
Special Precautions & Warnings:
We currently have no information for GARCINIA Interactions
The appropriate dose of garcinia depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for garcinia. Keep in mind that natural products are not always necessarily safe and dosages can be important.
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Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. View abstract.
Jena, B. S., Jayaprakasha, G. K., Singh, R. P., and Sakariah, K. K. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric.Food Chem. 1-2-2002;50(1):10-22. View abstract.
Kriketos, A. D., Thompson, H. R., Greene, H., and Hill, J. O. (-)-Hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post-absorptive state. Int J Obes.Relat Metab Disord. 1999;23(8):867-873. View abstract.
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Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. View abstract.
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Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. View abstract.
Ishihara K, Oyaizu S, Onuki K, Lim K, et al. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr 2000;130:2990-5. View abstract.
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Lim K, Ryu S, Nho HS, et al. (-)-Hydroxycitric acid ingestion increases fat utilization during exercise in untrained women.
The effect of a lessened appetite: unlike the topic of increased energy from taking GC, a reduced appetite is a proven benefit that has been studied extensively in many different trials.
After reviewing many products this is definitely the highest-quality one available.
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Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. View abstract.
Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94. View abstract.
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Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. View abstract.
Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180. View abstract.
Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. View abstract.
Schaller JL. Garcinia cambogia for weight loss. JAMA 1999;282:234; discussion 235. View abstract.
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Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. View abstract.
Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. View abstract.
Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91. View abstract.
Westerterp-Plantenga MS, Kovacs EMR. The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. Int J Obesity 2002;26:870-2. View abstract.
Garcinia Cambogia: Safe for Weight Loss?
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In this Article
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Garcinia cambogia, a tropical fruit also known as the Malabar tamarind, is a popular weight-loss supplement. People say it blocks your body's ability to make fat and it puts the brakes on your appetite. It could help keep blood sugar and cholesterol levels in check, too. You'll find it in bottles on the shelf at the store as well as mixed with other ingredients in diet products.
Does it live up to its hype? Maybe a little, but it might not be worth it.
How It Works
The active ingredient in the fruit's rind, hydroxycitric acid, or HCA, has boosted fat-burning and cut back appetite in studies. It appears to block an enzyme called citrate lyase, which your body uses to make fat. It also raises levels of the brain chemical serotonin, which may make you feel less hungry.
But actual weight loss results aren't impressive.
This particular blend has some serious weight-loss boosting additions to its ingredients list, with the likes of Green Coffee Bean, African Mango, Chromium Polynicotinate, Raspberry Ketones, and Green Tea.
A review published in the Journal of Obesityfound that people who took garcinia cambogia in studies lost about 2 pounds more than people who didn't take it. The reviewers couldn't say for sure that the weight loss was because of the supplement. It could have been from the lower-calorie diet and exercise programs the people in the studies typically followed. Better studies are needed to find out if HCA really helps people lose a lot of weight and keep it off.
Type 2 Diabetes and High Cholesterol
Garcinia cambogia may make it easier for your body to use glucose, the sugar your cells need for energy. Mice that got garcinia cambogia in one study had lower insulin levels than mice that didn't. That's another reason, besides weight loss, that people with diabetes are interested in it. However, if you're taking garcinia cambogia along with a medication to control your blood sugar, your glucose could get dangerously low.
Some research has found that garcinia cambogia can also improve cholesterol levels, lowering triglycerides and LDL (the "bad" cholesterol) and raising HDL (the "good" cholesterol). But you shouldn't use it if you're already on a prescription for your cholesterol.
Possible Side Effects
When you take garcinia cambogia, you might get:
In 2009, the Food and Drug Administration warned everyone to stop using a weight-loss product that contained garcinia cambogia because some people taking it got serious liver problems. The product had other ingredients, too, so it's not clear that garcinia cambogia was to blame. While some research suggests the supplement is safe for your liver, other research says no.
Garcinia cambogia may interact badly with:
You definitely don't want to use it when you're pregnant or nursing, or if you have kidney or liver problems. It is possible that manic symptoms may emerge as a side effect.
To Buy or Not to Buy
Since study results are mixed, you should talk with your doctor to help you decide if taking garcinia cambogia is a good idea. Even if it's safe, it may not help you lose much weight. It's probably wiser to spend your money on healthy food or an exercise DVD.
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Can Garcinia Cambogia Help with Weight Loss?
Is there such a thing as a weight loss miracle drug?
Today’s market is full of “miracle drugs” and supplements that claim to help you drop pounds fast.
Western scientists who encountered the fruit, decided to study its weight loss abilities and discovered that the rind contains massive amounts of HCA – which is short for Hydroxycitric Acid.
It’s no wonder they fly off the shelves and into medicine cabinets across the country. TV personality Dr. Oz and others like him have showered praise on one of these products in particular: the controversial garcinia cambogia fruit.
Garcinia cambogia is a citrus fruit that grows in Southeast Asia. An extract from the fruit’s rind, hydroxycitric acid (HCA), has historically been used for cooking, but it has also been used for weight loss. You can buy garcinia cambogia online or at most health and supplement stores. It comes in pill form or as a powder. Let’s look at what, if anything, garcinia cambogia can do for your weight.
Advocates say that HCA, an organic acid, works by making you feel full, reducing your appetite, and affecting your metabolism. It’s this effect that has led many to herald it as a natural weight loss cure. Some say it may also help improve high cholesterol or enhance athletic performance.
The list of garcinia cambogia’s rumored benefits is a long one. It can be hard to determine the truth to the claims about its “miracle” properties. So, how do these health claims match up to scientific research?
1. Claim: Makes you feel full
Verdict: No evidence. An extensive review of the existing research on garcinia cambogia determined that there simply wasn’t conclusive evidence to suggest that the supplement or HCA had any effects on appetite and satiety. Although some rodent studies had positive results, no human studies could replicate them.
2. Claim: Lowers body weight
Verdict: No evidence. Existing evidence doesn’t prove that garcinia cambogia alone can facilitate weight loss. A 12-week, randomized, double-blind, placebo-controlled study published in JAMA found that the supplement didn’t help with significant weight loss or decrease in fat mass. Both the control and garcinia group were placed on high-fiber, low-calorie diets.
3. Claim: Speeds metabolism
Verdict: Some evidence. There is some evidence that supplementing with garcinia cambogia can influence fat metabolism. Several studies have found that both mice and humans experience an increase in fat metabolism after supplementing with HCA.
4. Claim: Enhances athletic performance
Verdict: Some evidence. Garcinia cambogia may increase the amount of time it takes to reach exhaustion during exercise, according to one study. Another study that used mice had similar results, showing that HCA enhanced endurance during running.
In addition to knowing how well it works, you’ll also want to know about a supplement’s potential side effects. Reported side effects for garcinia cambogia are mild. They include:
There are still other factors you should consider when deciding whether to use a supplement such as garcinia cambogia.
As with all dietary supplements, HCA could interact with medications you take. Before starting HCA, be sure to talk to your doctor. Make sure they know about all medications you take, including prescription and over-the-counter drugs as well as other supplements.
Part of the allure of garcinia cambogia is the fact that it comes from a fruit, so it’s considered “natural.” However, this alone doesn’t make it a worthwhile supplement or even safe.
cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis.
The Food and Drug Administration (FDA) recommends using caution with products that claim to be quick fixes, promise fast weight loss, and use the term “natural.” Natural doesn’t necessarily mean safe. There are many poisonous plants that are natural, but can cause you serious harm. Many plants interfere with medication or are actually medications themselves.
More importantly, dietary supplements such as garcinia cambogia aren’t studied or approved by the FDA before they go on the market. Furthermore, supplement makers can claim that their products support normal body functions as long as they have a disclaimer stating that the FDA hasn’t evaluated those statements. In other words, supplements containing garcinia cambogia have not been rigorously tested for effectiveness, quality, purity, or safety.
Possible liver problems
In 2009, the FDA recalled a product that contained garcinia cambogia because it was found to cause liver problems. Research since then has been conflicted, with some citing a link between garcinia cambogia and liver damage and other research finding no link. You should discuss this risk with your doctor.
A review of studies on HCA found that no studies have effectively looked at garcinia cambogia use for longer than 12 weeks. That means there isn’t enough evidence to ensure that it’s safe and effective for long-term use.
The danger of scams
It’s free, so what’s the harm, right? Actually, those free trials for products that claim to help you lose weight fast can present more harm than you might think. From surprise shipping fees to extra charges for products you didn’t realize you ordered, these trials can end up costing you money. For information on how to avoid these scams, check out this page from the Federal Trade Commission.
“Miracle” weight loss solutions rarely live up to the hype. Even when there is scientific evidence of positive results, the results are often so mild and minimal that users are disappointed to learn they still have to exercise and control their eating in order to reap lasting and significant weight loss.
Dr. Oz has come under fire for promoting “miracle” weight loss products on his show. His claims got him into trouble with the U.S. Senate Subcommittee on Consumer Protection, Product Safety, and Insurance. There’s a reason that claims such as his about products with no clear evidence of effectiveness are taken seriously. Many consumers trust his opinion and could be misled into buying something that is, at best, a waste of time and money, and at worst, laden with potential side effects.
According to the FDA, any product, whether natural or man-made, that’s strong enough to work like a drug is capable of producing side effects. Before you add a dietary supplement to your weight loss plan, discuss it with your doctor. They can tell you if the product may be harmful or may be worth a try.
The best approach for weight loss is eating less fat and calories. Choose to eat whole, non-processed foods and burn calories with activity.