Garcinia cambogia 50 hca 500 mg
After reviewing many products this is definitely the highest-quality one available.
Garcinia (hydroxycitric acid)
Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)
Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )
The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.
The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.
Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .
Information regarding safety and efficacy in pregnancy and lactation is lacking.
The herb has documented drug interactions.
At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.
Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.
The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2
Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4
HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10
Uses and Pharmacology
The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.
In vitro and animal data
In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12
In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13
The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14
A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17
In an 8-week randomized clinical trial, 40 patients were given either placebo or G.
Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ.
cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2
In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18
In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14
Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23
An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19
Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19
Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24
Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2
Other pharmacologic activity
Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26
The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27
Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29
HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32
Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35
Red blood cell count
A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36
The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.
Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37
In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29
G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36
Potassium and calcium supplements
Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.
A mouse study using a commercial polyherbal product containing G.
In this study, the HCA group lost an average of 10.5 pounds compared to the placebo group, which lost an average of 3.5 pounds.
That being said, we present you the best Garcinia tablets you can safely use.
cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38
Singulair (or leukotriene receptor antagonists)
One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39
A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40
In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41
A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42
Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47
No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49
2. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol . 2004;42(9):1513-1529.
3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.
4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.
5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.
6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.
7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.
8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.
9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.
10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.
11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.
12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.
13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.
14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.
15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.
16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.
17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.
18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.
19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.
20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.
21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.
22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.
23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med .
NYU Langone Medical Center: "Weight Loss Aids." Byrne, S.
24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.
25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.
26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.
27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.
28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.
29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.
30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.
31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.
32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.
33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.
34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.
35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.
36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.
37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.
38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.
39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.
40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.
41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.
42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.
43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.
44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.
45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.
46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.
47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.
48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.
49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.
Copyright © 2009 Wolters Kluwer Health
Cos'è la garcinia?
La garcinia è una droga vegetale ricavata dalle bucce del frutto di Garcinia gummi-gutta.
Resa nota dal Dr Oz - noto personaggio televisivo degli Stati Uniti, che l'ha definita “un importante passo avanti nella perdita di peso naturale” - la Garcinia ha conosciuto un aumento vertiginoso della sua popolarità dalla fine del 2012.
La Garcinia cambogia è anche conosciuta con i nomi di Garcinia gummi-gutta, brindleberry, Malabar tamarindo e Kudam puli.
La pianta della Garcinia cambogia si presenta come un albero di medie dimensioni dal tronco legnoso, che cresce spontaneo negli ambienti tropicali, tipici dell'Indonesia e di Paesi come Vietnam, Cambogia, Filippine e regioni meridionali dell'India.
Il frutto dal quale si estrae la buccia, quindi la droga, è simile a una “piccola zucca” di colore intermedio tra il verde e il giallo chiaro.
Nonostante la garcinia abbia goduto di una certa “attenzione” mediatica, in virtù dei suoi presunti effetti dimagranti, non ci sono sufficienti evidenze cliniche che indichino effetti certi e significativi sulla perdita di peso.
Composizione della garcinia
La droga estratta dalla Garcinia cambogia contiene:
- Pectine: fibre solubili viscose che modulano l'assorbimento intestinale, prevengono la stipsi e fungono da prebiotici.
- Calcio: minerale indispensabile all'integrità dello scheletro e alla trasmissione dell'impulso nervoso e muscolare
- Carboidrati: macronutrientienergetici che forniscono 3,75 chilocalorie per grammo.
- Acido idrossicitrico (10-50% sulla sostanza secca): principio attivo caratteristico di questa droga che interviene nel metabolismo lipidico cellulare.
Quando usare la Garcinia cambogia?
La Garcinia cambogia dovrebbe:
Proprietà ed Efficacia
Le proprietà fitoterapiche della garcinia sarebbero imputabili all'effetto blandamente epatotossico dell'acido idrossicitrico.
Rispetto al più comune acido citrico (abbondante negli agrumi e ampiamente utilizzato dall'industria alimentare come conservante), l'acido idrossicitrico è estremamente raro in natura.
Questa sostanza abbonda soltanto nei frutti delle piante appartenenti al Genere Garcinia, come la Garcinia indica, la Garcinia cambogia e la Garcinia atroviridis.
Proprietà della Garcinia cambogia
Garcinia per dimagrire e contro le dislipidemie
L'acido idrossicitrico contenuto nella garcinia è in grado di bloccare la sintesi di acetil coenzima A (acetil-CoA), un substrato energetico utilizzato dall'organismo per la sintesi di colesterolo e altri lipidi.
If you seriously want to get back to your desired shape, then Garcinia Cambogia Extract is the answer to all your problems!
Da qui il suo effetto teoricamente positivo nel dimagrimento e nel ripristino della lipemia fisiologica.
Un aiuto nel controllo del peso potrebbe derivare anche dalle presunte proprietà anoressizzanti della garcinia, che si traducono in una riduzione dell'appetito attraverso la modulazione dei livelli di serotonina.
Efficacia della Garcinia cambogia
La Garcinia cambogia funziona?
Come per molti altri integratori, anche la sperimentazione della Garcinia, nonostante i presupposti incoraggianti, ha condotto a risultati contradditori.
Nel tentativo di implementarne l'effetto dimagrante, viene spesso associata ad altri integratori comunemente utilizzati nel trattamento del sovrappeso, come:
D'altro canto, anche in proposito non sono state dimostrate differenze significative tra gli effetti della garcinia e quelli del placebo.
Nelle sperimentali che hanno mostrato una leggera perdita di peso, gli effetti collaterali si sono rivelati eccessivi.
Alcuni commercianti di garcinia sostengono che l'associazione di HCA-SX (acido idrossicitrico in complesso con calcio/potassio), con cromo polinicotinato legato alla niacina (vitamina PP), o con Gymnema sylvestre, potrebbe aumentare l'effetto dimagrante. Non vi sono evidenze scientifiche significative a riguardo.
Dosi e Modo d'Uso
Come usare la Garcinia cambogia?
In commercio esistono integratori di Garcinia contenenti percentuali diverse di acido idrossicitrico. In Italia sono presenti soprattutto prodotti a base di acido idrossicitrico al 50%.
La dose giornaliera consigliata, nel caso si mantenga tale concentrazione, varia dai 500 ai 2.000 mg di estratto secco di garcinia al giorno (250-1000 mg di acido idrossicitrico).
Quali sono gli effetti collaterali più frequenti della Garcinia cambogia?
La garcinia non presenta effetti collaterali degni di nota e si è dimostrata pressoché innocua.
Alcuni soggetti hanno comunque riportato effetti indesiderati come mal di testa e sintomi gastroenterici (diarrea, crampi, meteorismo ecc.), da lievi a moderati.
In particolare, l'assunzione orale di 500 mg di acido idrossicitrico PURO quattro volte al giorno può causare nausea, disturbi gastrointestinali e mal di testa.
L'effetto epatotossico che sta alla base del presunto meccanismo dimagrante ha giocato un ruolo negativo nelle vendite a lungo termine del prodotto.
Quando non dev'essere usata la Garcinia cambogia?
Il suo utilizzo è controindicato:
- In gravidanza e allattamento
- In presenza di malattia degenerativa di Alzheimer e altre forme di demenza (la garcinia può incrementare la sintesi cerebrale di acetilcolina)
- Per chi soffre di diabete mellito (soprattutto in terapia farmacologica)
- Per chi soffre di epatopatie
- In presenza di ipersensibilità o allergia specifica.
Peraltro, se la Garcinia cambogia viene utilizzata in associazione ad altri integratori per così dire "dimagranti" (soprattutto termogenici), è necessario considerare il potenziale effetto additivo dei singoli effetti collaterali, che riguardano soprattutto l'apparato gastrointestinale e il sistema nervoso.
Quali farmaci o alimenti possono modificare l'effetto della Garcinia cambogia?
La Garcinia cambogia potrebbe alterare la glicemia.
In particolare, sembra capace di ridurre (in quantità soggettivamente variabile) i livelli di glucosio plasmatico.
Per questo motivo, è consigliabile fare molta attenzione a un eventuale effetto sinergico tra la garcinia e i farmaci ipoglicemizzanti comunemente utilizzati nel trattamento del diabete mellito tipo 2.
Decidendo comunque di assumere la Garcinia cambogia, si raccomanda il consulto medico.
Note: è consigliabile iniziare l'integrazione con un dosaggio basso ed, eventualmente, incrementarlo con gradualità.
Ci sono stati diversi casi clinici di pazienti che hanno sviluppato la "sindrome serotoninergica" dopo la combinazione di “farmaci serotoninergici” con Garcinia cambogia.
Pertanto si deve usare cautela anche nel trattamento delle seguenti classi di farmaci:
Precauzioni per l'Uso
Cosa serve sapere prima di prendere la Garcinia cambogia?
In sintesi, prima dell'assunzione di Garcinia cambogia bisogna tenere a mente che:
- Gli effetti terapeutici non sono garantiti.
- Soprattutto ad alti dosaggi, può scatenare effetti collaterali soprattutto gastrointestinali.
- E' da evitare in caso di gravidanza, allattamento, demenza, patologie epatiche, diabete e allergia.
- Sarebbe meglio evitarla in caso di terapia farmacologica come menzionato sopra.
Garcinia cambogia 50 hca 500 mg
Garcinia cambogia is a small, sweet, purple fruit also known to some as Malabar tamarind. People who live near where it grows have used the fruit for hundreds of years because over time they have noticed certain beneficial properties after daily consumption.
Today, modern science has caught up to traditional wisdom about the human body. The result is an understanding of Hydroxycitric acid, which is able to be extracted from garcinia cambogia and used in nutritional supplements.
What is HCA Extract?
Hydroxycitric acid (HCA) is a derivative of citric acid that is extracted primarily from the rind of the garcinia cambogia fruit. This is primarily what offers benefits to the human body.
Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a safe, natural supplement for weight management. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. Previous studies in our laboratories have demonstrated the superior bioavailability of a novel calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax). Greater bioavailability of HCA-SX was observed when taken on an empty stomach (Source: An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management )
While HCA extract works as an appetite suppressant, other benefits may be seen when Hydroxycitric acid based supplements are taken on a daily basis.
What are the Benefits of Garcinia Cambogia?
The benefits of garcinia cambogia are plentiful.
It is because fat accumulation covers the intestines and stomach.
Here are some of them.
- Slow Fat Production – One of the benefits of garcinia cambogia extract is that it helps slow down fat production in the body through working with the carbohydrates you eat during the day.
- More Efficient Metabolism -Hydroxycitric acid is thought to help the metabolism by helping control how carbohydrates are used by the body. Instead of excess carbs being turned into fat cells for later use they are used throughout the day. This can lead to loss of existing fat cells.
- Cholesterol Control – More studies need to be done in this area, but some people have suggested HCA extract causes carbohydrates to be converted into glycogen instead of fat and that this disrupts the production of triglycerides – the bad cholesterol.
- Increased Serotonin – HCA extract may also help with serotonin production in the body. When serotonin levels are low problems with anxiety, insomnia or even depression may develop. Serotonin is an essential hormone for happy and healthy humans.
- Appetite Suppression – Proper amounts of HCA extract can also work as a natural and effective way to suppress the appetite. This is one of the ancient uses of garcinia cambogia and one of the major reasons HCA supplements help people lose weight.
Other benefits of garcinia cambogia may exist, but the ones mentioned above are the ones most people are interested in HCA. TO LEARN MORE ABOUT WHERE TO PURCHASE GARCINIA CAMBOGIA CLICK THE LINK BELOW: (now available in US,UK,CA,NZ,AU)
Garcinia Cambogia for Weight Loss
While other benefits are known, there is no verdict on whether HCA extract can help with weight loss efforts. NYU Langone Medical Center has mentioned these HCA studies.
In an 8-week double-blind, placebo-controlled trial of 60 overweight individuals, use of HCA at a dose of 440 mg 3 times daily produced significant weight loss as compared to placebo.(Source: Thom E. Hydroxycitrate (HCA) in the treatment of obesity [abstract]. Int J Obes Relat Metab Disord. 1996;20(suppl 4):75.)
In contrast, a 12-week, double-blind, placebo-controlled trial of 135 overweight individuals, who were given either placebo or 500 mg of HCA (as Garcinia cambogia extract standardized to contain 50% HCA) 3 times daily, found no effect on body weight or fat mass. (Source: Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA.1998;280:1596-1600.) However, this study has been criticized for using a high-fiber diet, which is thought to impair HCA absorption. (Source: Badmaev V, Majeed M, Conte AA, et al. Garcinia cambogia for weight loss [letter]. JAMA. 1999;282:233-234.)
A 12-week double-blind trial of 89 individuals found that HCA had no effect on appetite.(Source: Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71:87-94.) Another study tested HCA to see if it could cause weight loss by altering metabolism, but no effects on metabolism were found.(Source: Kriketos AD, Thompson HR, Greene H, et al. (-)-Hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post-absorptive state. Int J Obes Relat Metab Disord . 1999;23:867-873.)
Many other studies have been conducted. Some of them have been on rats, but all the information has been useful to learn more about HCA extract and the ways in which it might affect the human body.
Does HCA Extract Have Side Effects?
As with anything ingested into the body, some people may develop side effects after taking supplements with HCA extract. If this is the case, consulting a doctor is recommended.
Here are some of the possible side effects of garcinia cambogia when taken in high doses.
- Gastrointestinal problems including intestinal pain, nausea, vomiting and diarrhea.
- Lower blood sugar levels
Additionally, some people may have an allergic reaction to Hydroxycitric acid. Many find the side effects associated with garcinia cambogia to be less than those that may occur when using other drugs to help with health or weight loss efforts.
What About Garcinia Cambogia Drug Interactions?
Currently, no information is known about possible interactions between HCA extract and other drugs. This may change as further studies are conducted. Those who are considering taking a garcinia cambogia supplement and are taking other medications should consult a physician.
What is the Recommended Dose of HCA Extract?
A standard recommended dose of HCA extract will range from 200 mg to 1,000 mg up to three times per day. Taking more than 3,000 mg of Hydroxycitric acid in any 24 hour period is not recommended. For the most benefit, supplements should be taken a half hour before meals throughout the day. The exact dosage for any person may vary according to a variety of different variables and circumstances.