Garcinia cambogia and depression medication

Garcinia cambogia and depression medication
It curbs your hunger, and helps you to eat less since you are already feeling good about yourself and don't need to use food to feel better emotionally.

Garcinia Cambogia: Weight-Loss Supplement May Be Toxic to Some

The use of Garcinia cambogia, a popular weight-loss supplement, may pose health risks to people who are taking certain antidepressants, a recent case report suggests.

Last year in Oregon, a 35-year-old woman who had been taking Garcinia cambogia supplements for two or three months while also taking an antidepressant started stuttering and sweating profusely. In the emergency room of a local hospital, the medical staff noted that the woman's heart rate and blood pressure were high, and that she had also developed foot clonus, involuntary muscle spasms that cause a person's foot to flex.

The woman's symptoms were characteristic of serotonin toxicity, a drug reaction that occurs when levels of the neurotransmitter serotonin are too high. After the woman was given medication for serotonin toxicity and spent a few days at the hospital, her symptoms subsided and she eventually recovered. [14 Oddest Medical Cases]

"I am hesitant to label it [Garcinia cambogia] as a dangerous supplement, because until we see more than one case, we want to make sure that this actually is something that is going to occur," said Dr. Robert Hendrickson, one of the authors of the case report.

However, previous studies on people and animals have shown that Garcinia cambogia may, indeed, increase serotonin levels. And taking the supplement in combination with antidepressants known as selective serotonin reuptake inhibitors (SSRIs), which also cause serotonin levels to rise, could lead to serotonin toxicity, said Hendrickson, a toxicologist at the Department of Emergency Medicine of Oregon Health and Sciences University.

Hendrickson added that, based on the animal and human data suggesting both SSRIs and Garcinia increase serotonin levels, he recommends that people who are taking an SSRI not use Garcinia, at least until further research is done. "Not because I know that it will be dangerous, but because there is a chance that it could be," he said.

"If I had a family member or a patient who was considering starting Garcinia and they were on an SSRI, I would recommend that they don't do it for now," Hendrickson told Live Science.

Garcinia cambogia, also known as tamarind, is a small, pumpkin-shaped fruit, and diet supplements made from it are touted for helping people lose weight.

In this supplement, HCA works with potassium and calcium, which help you to boost your body metabolism.

However, researchers have so far found only mixed results when looking at whether the supplement really helps weight loss. And one study in rats suggested that extremely high doses of Garcinia may cause testicular atrophy, and toxicity.

The woman in the case report had been previously diagnosed with serotonin toxicity while she was taking a different kind of antidepressant. At that time, she had also been taking Garcinia for a month or two, but she didn't tell the doctor who prescribed her antidepressant that she had also been taking the weight-loss supplement, Hendrickson said.

Therefore, her doctor attributed her first case of serotonin toxicity to her first antidepressant, and switched her to another one. Then, she developed her second case of toxicity, for which Hendrickson saw her.

"The question is whether this person was uniquely susceptible to this problem, or if this is a bigger problem," Hendrickson said. "And I suspect, over the next year or two, if this is a bigger problem — given the number of people taking Garcinia — we will see if there are a lot more people with this toxicity."

The researchers said they cannot be absolutely sure that it was, indeed, the use of Garcinia that caused the patient to develop serotonin toxicity. Another potential, but less likely, trigger of the reaction, could have been the SSRI that she had been taking. Moreover, it is also possible that although the supplement she was taking was labeled as Garcinia, it might not have contained the supplement, but rather some other substance, Hendrickson said.

"There is a big difference between a pharmaceutical, like a medication, and a supplement," Hendrickson said. Medications are highly regulated. "Supplements, on the other hand, are completely unregulated," he said. Whereas people can be relatively certain that a bottle of medication contains the ingredients that it is supposed to contain, the same cannot be said about supplements. [Aspirin to Zoloft: How 4 Common Medicines Work]

"There is no regulatory agency that's watching that says that you had to test it and prove that there is Garcinia in it," Hendrickson said, adding that there is also currently no way to test whether a certain pill really contains Garcinia or not.

Previous research has shown that some supplements did not contain the herbs or other substances that their bottles said they contained.

That means you need to have a killer bod along with some really fashionable clothes.

It seem as if once some negative news start spreading about them, they instantly take their products off the market only to re-brand them with a new name and new packaging and be back on the scene a few weeks later.

Moreover, there have also been instances in which other substances sold as supplements contained pharmaceutical agents, Hendrickson said.

For instance, valerian root supplement pills that are sold as an herbal sleep aid have been found to contain valium, as it was cheaper for the pill manufacturer to use the drug than the herb, he said.

However, most capsules labeled Garcinia likely do include Garcinia, Hendrickson said. And because previous studies have shown that Garcinia causes a serotonin increase, it is quite likely that this also occurred in the case discussed in the study, the researchers said.

The study was published online April 4 in the Journal of Medical Toxicology.

Can you mix wellbutrin and garcinia cambogia?

I am bipolar or they think. I have had bouts of depression and I started taking garcinia cambogia and went up on wellbutrin at the same time . I sort of lost tract of time and wasn't acting right so I went off the wellbutrin. But I went back on because I started gaining weight without it. Is 75 mgs enough for depression?

Responses (1)

Hi, j! It's not a good idea to mix Wellbutrin and garcinia as both affect serotonin levels in the brain which can cause unsual symptoms, or even lead to a very serious condition called serotonin syndrome which can be fatal.

I'd be sure to talk to the doctor who prescribed your Wellbutrin. Mixing herbals with prescription medications can have very serious consequences and your doctor should be aware of EVERYTHING you take, including any vitamin or mineral supplements..

75mgs is a very low dosage for Wellbutrin.

Best wishes, WCV

Thank You. JoAnne

I'm sorry WildcatVet but I have to respectfully disagree with your post. Wellbutrin is not an SSRI or selective serotonin reuptake inhibitor, instead Wellbutrin works more with your dopamine in your brain. I do not believe that this patient would be at any risk for Serotonin Syndrome however I will agree with you that everyone should check with their General Practitioner before adding any medications including minerals and vitamins to their daily regimen. I also agree the 75mg is a very low dose for Wellbutrin.

Happy Holidays!!

I highly recommend the Art of Breathing course as an oxygen therapy to reverse the aging process and prevent disease.


Wellbutrin actually does not inhibit serotonin reuptake, it affects dopamine levels. I don't know if that makes it safe with Garcinia but you're clearly not well informed.

Wellbutrin does NOT affect serotonin levels. Bupropion inhibits the re-uptake of norepinephrine and dopamine neurotransmission without any significant direct effects on serotonin neurotransmission.

Brain transmitters interact with each other in ways that are not fully understood. Raising or lowering levels of one may affect others and their receptor sites.

It is not safe to mix psychotropic drugs unless under a physician's supervision.

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Does Garcinia Cambogia Improve Mood?

Garcinia Cambogia has garnered serious attention since it was first discovered to aid weight loss and inhibit fat cells before they can develop in your body. But, did you know that Garcinia Cambogia can also aid in the treatment of depression and can be used as a mental stimulant as well?

Doctors have recently discovered that Garcinia Cambogia, the natural supplement derived from a tropical fruit may actually hold the key to not only losing weight and keeping it off, but has recently been proven to improve mental health as well.

How does it work?

Garcinia Cambogia contains a chemical substance called hydroxycitric acid, or HCA. Hydroxycitric Acid is found within the skin of the Garcinia Cambogia fruit and has been proven to greatly increase levels of serotonin in the brain. Serotonin is a neurotransmitter. Neurotransmitters vastly influence your mental clarity, while stabilizing your mood, and can even help decrease appetite.

Adequate amounts of serotonin are necessary for a stable mood and to balance any excessive stimulating neurotransmitters from firing off in the brain. Excessive amounts of caffeine as well as other factors can cause a depletion of serotonin in the brain over time.

It has been recently estimated that about 86% of Americans have below standard working neurotransmitter levels. Because HCA found in Garcinia Cambogia is a natural fruit derivative, it is currently considered the safest way to elevate serotonin levels and eliminate depression and moodiness.

What the latest studies show

Recent studies conducted on lab animals show that HCA helps rapidly increase serotonin levels. Studies show that the active ingredient HCA found in Garcinia Cambogia can inhibit a fat producing enzyme called Citrate Lyase and can greatly increase serotonin levels, leading to significant weight loss as well as mood stabilization.

Serotonin holds a powerful influence over stabilizing a persons mood, emotional health, memory loss, cravings, self-esteem and confidence, sleep, appetite, digestion and body temperature control.

This natural ability to put the brakes on your appetite made Western scientists pay attention to this very simple but very effective natural appetite-suppressing fruit.

Anyone who has ever experienced depression knows that when we feel depressed or down, we naturally crave more sugars and starches and excessive carbohydrates to stimulate the production of serotonin.

This can often be the result of low serotonin levels. To greatly increase and steady your Serotonin and Cortisol levels, use proven Garcinia Cambogia. You will begin to see a real change in what you used to believe were emotionally insecure eating habits.

What a lot of people do not realize is, remembering to take in plenty of sunlight and maintain a healthy diet rich in protein, minerals and vitamins can work wonders for helping to raise serotonin levels. Regular exercise and a good nights sleep can also significantly support serotonin levels. And now we know that HCA and Garcinia Cambogia used regularly can improve serotonin levels leading to weight loss and an improvement in your mood.

Doctors now acknowledge that here is a significant link between mental imbalances and difficulty losing excess weight. There have also been numerous studies that have shown obesity related to depression and excessive overeating. If you have been unsuccessful in the past with your weight loss, chances are pretty good that you may have a loss of serotonin. If you are like so many others, and you keep trying different diets.

Diets that seem to work for others but just do not seem to make a difference with your weight loss, consider taking Garcinia Cambogia Extract as a dietary supplement as well as a serotonin stimulant. It has been proven to be a safe and effective as a weight loss treatment and mood stabilizing dietary supplement. Take the natural path to healthy living.

Stop trying to do everything on your own, and try using Garcinia Cambogia Extract. I’m constantly hearing stories from people telling me how much it has changed their lives. Not only because it helped them lose weight but also because it just makes them feel better. The proven herbal supplement that will give you energy, boost your mental wellness and turn your frown upside down!