Garcinia cambogia double blind studies

Garcinia cambogia double blind studies
In other words, it makes a person feel less hungry and allows them to feel fuller quickly after meals so as to avoid overeating.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

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Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight.

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G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX).

It’s very important that you equip yourself with the knowledge and qualifications of what a top quality and effective garcinia cambogia product is so you know you’re getting an authentic product that’s safe and most of all, effective.

1.5 You have a statutory right to a "cooling off" period.

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4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci .

I decided not to take any risks by taking the supplement.

2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.

45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.

47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.

48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.

49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

Copyright © 2009 Wolters Kluwer Health

Truth about garcinia cambogia and apple cider vinegar diet!

Table of Contents

Garcinia Cambogia and Apple Cider Vinegar: A revolutionary diet or a dangerous hype?

Garcinia cambogia became famous after Dr.Oz called it the “holy grail of fat loss” on his popular talk show.

Here’s what you can expect from this article:

  1. Quick facts about Garcinia.
  2. An in-depth overview of everything Dr.Oz said about Garcinia Cambogia.
  3. A quick check on if/how many of those claims are true.
  4. How Apple Cider Vinegar works for weight loss.
  5. Garcinia Cambogia and Apple Cider Vinegar diet recipe
  6. Frequently Asked Questions (FAQ)

Spoiler Alert: Garcinia doesn’t work. It doesn’t have human trial studies to back up its weight loss claims. Keep reading and you’ll understand it for yourselves. And that Anna Haughman CNN story is a hoax!

But before that, I really have to share this with you.

Somewhere during my research process on Garcinia, I found out that it has been used as a flavoring agent for fish curries.

Wait a second…fish curries?

I had my aha moment and decided to Google the Tamil/Sinhala name of Garcinia.

And to my surprise, it turns out this sweetypie is what we (Srilankans) call Goroka.

For those interested, Garcinia is called Kudampuli (Pot Tamarind) in Tamil.

And we are those people who traditionally use Garcinia Cambogia to flavor our fish curries.

It’s a staple in every Srilankan kitchen.

Let me tell you this, Garcinia (Goroka) flavored fish curry, also known as Ambul Thiyal is one of the best things Srilankans have discovered.

A picture of Garcinia Cambogia I took from our kitchen cupboard:

Dried fruit version of Garcinia from our kitchen…

What is Garcinia Cambogia and where is it from?

Garcinia Cambogia, also known as Malabar Tamarind, is a pumpkin shaped fruit that originates from south-east Asia and India.

The rind of this sour fruit is used as a traditional flavoring agent for fish curries.

It’s a staple in every Srilankan kitchen cupboard and that’s coming from a Srilankan (Me).

There are claims that Garcinia has been used as a home remedy for bowel problems, intestinal parasites and rheumatism [ 1 ].

As mentioned earlier, Garcinia Cambogia became super famous after Dr. Oz labeled it as the “revolutionary fat buster” in his show.

An Overview of Everything Dr. Oz said about Garcinia Cambogia

He’s the name behind the success of this viral weight loss supplement, so it only makes sense to start off with his claims right?

According to Dr.Oz, Garcinia Cambogia is the:

  1. “Holy grail” of weight loss.
  2. “Newest, fastest and least expensive fat buster”.
  3. “Revolutionary fat buster you’ve been waiting for.”

Let’s go through each claim about Garcinia from Dr.Oz show.

What does Garcinia Cambogia do for you?

These are the exact words of Doctor Julie Chen from Dr.Oz show:

It’s actually been seen in studies to help increase weight loss by 2-3 times, what people would naturally lose with just diet and exercise alone.

See the bolded words above?

Those words are what pretty much sold Garcinia Cambogia on the show.

I mean who wouldn’t like the idea of munching on KFC, sitting on the sofa all day and still lose that stubborn belly fat?

How does Garcinia Cambogia work for weight loss?

According to Dr.Oz, Garcinia cambogia works for weight loss in 2 ways:

  1. By blocking fat production and converting excess sugar into energy.
  2. By dealing with emotional eating. This works as an appetite suppressant.

What they repeatedly claimed is that Garcinia inhibits the production of fat in the body.

So if the body is not making fat, it will burn the fat it already has.

They also said that Garcinia Cambogia increases the production of serotonin in your brain.

Serotonin is a compound that helps avoid excess eating by making you feel fuller longer.

How is Garcinia different from all the other weight loss supplements out there?

Were you wondering about that?

Dr.Oz can read your mind because he asked that question to Julie Chen and she said:

Because it suppresses appetite and it helps to prevent fat from being made in the body. It moves it towards glycogen which is actually an energy source for the muscles to burn when you exercise.

Dr. Oz did a demonstration in which he explains how the liver turns excess sugar into fats.

He showed how Garcinia Cambogia will block the enzyme that turns the sugar into fats.

He explained that Garcinia uncorks the pathway that allows sugar to be converted into energy.

Here is another EPIC comment by Dr.Oz regarding Garcinia:

Your fat cells can begin to shrink out and convert into energy. Now even if you eat sugar, you’re unable because of Garcinia to make more of that fat cell.

That means you can eat your Ice cream, Pizza with double cheese and still get ready to brace the bikini season!

The whole focal point of their discussion is that Garcinia helps burn fat and not the muscle because it converts into energy that helps build muscle.

Other claims made on the Dr.Oz show:

  1. It doesn’t just help with weight loss, Garcinia also helps with overall body health.
  2. They saw in studies that patients had a decrease in total cholesterol, triglycerides, LDL.
  3. Improvement in HDL which is a good cholesterol.
  4. Those studies saw improvements in patients with obesity.

Watch Dr.Episode about Garcinia Cambogia:

Where is the REAL Evidence to prove these Weight loss claims about Garcinia Cambogia?

I’m yet to find those “studies” talked about in Dr.Oz show.

If anyone gets hold of accurate studies supporting the above claim about Garcinia, please feel free to send me the link.

However, I’ve found a research paper that concludes Garcinia Cambogia works for weight loss in the short term.

It says that the magnitude of the weight loss is so small that it requires more rigorous future trials to draw any serious conclusions [2, 3].

Another research paper has also concluded about the lack of human trial evidence to support the claim about Garcinia Cambogia for weight loss [ 4 , 6 ].

It points out that most studies in humans have been conducted on small samples.

All of those studies have failed to show the long-term effect of Garcinia for weight loss.

Does Garcinia Target Belly Fat?

Now here is an interesting finding.

Earlier we read that there isn’t much evidence to support the claims of weight loss caused by Garcinia Cambogia.

Here are 2 studies stating that Garcinia can help lose visceral fat (belly fat).

The first study was carried out on mice and the second was on humans.

Study 1: This study was carried out on obesity-prone mice.

They were fed with high-fat diet for 16 weeks.

One group was given Garcinia Cambogia every day and another group was a control.

Results: No significant changes in body weight and food intake between both groups of mice.

However, they found out that the group of mice that had Garcinia had a significant reduction in their visceral fat (belly fat) [ 5 ].

Study 2: Double-blind, randomized and placebo-controlled.

This study was carried out on a group of men/women aged 20-65 years.

They all had a visceral (belly) fat area of 90cm or more [9].

  1. One group received 1000 mg HCA (Garcinia Cambogia) per day.
  2. The other group received placebo.
  3. The treatment was given for 12 weeks.
  4. After 12 weeks, both groups were given placebo for 4 weeks to assess any rebound effect.

Findings: After 16 weeks, the group that received Garcinia Cambogia had a significant reduction in visceral fat compared to the control group.

They also didn’t see any rebound effect from week 12 to 16 without Garcinia.

Regardless of their gender, both groups that received Garcinia showed belly fat reduction.

Bottom line: The belly fat loss from Garcinia was mentioned in Dr.Oz show and this is probably one of the rare studies out there to support that claim.

There still needs to be more human trial research to draw any serious conclusions.

This is primarily because of some of the rumored side effects of Garcinia.

Let’s Talk About Apple Cider Vinegar for Weightloss!

Apple Cider Vinegar is widely popular for its antifungal, antibacterial, antidiabetic and antioxidant properties [ 7 ].

As for its weight loss properties, here’s what a double-blind trial study found:

Participants: Japanese obese individuals with the same body weight, BMI and waist circumference [ 8 ].

  1. All participants were divided into 3 groups.
  2. Each group was given 500 ml of a beverage containing either 15 ml vinegar, 30 ml vinegar or 0 ml vinegar.
  3. They were given this treatment every single day for 12 weeks.

Results: The study found out that both groups that took the Vinegar beverage had significant weight reduction than the placebo group.

They also noticed more reduction in belly fat.

Bottom line: Apple Cider Vinegar actually has more reliable evidence for weight loss than Garcinia in human trial studies.

Garcinia Cambogia and Apple Cider Vinegar Diet Recipe

This is the method used and recommended by everybody to lose weight with the Garcinia Cambogia and ACV diet.

What you will need:

Pure Garcinia Cambogia Capsules: Buy a brand that’s FDA approved and has 60% HCA with no fillers etc.

Apple Cider Vinegar with the mother (Bragg’s is an excellent choice)

8 ounces of warm water in a glass.

A straw: To protect your teeth/enamel from any damage by the ACV.

  1. Mix 2 teaspoons of Apple Cider Vinegar into a glass of 8 ounces of warm water.
  2. Swallow the Garcinia Cambogia and drink the ACV water.

When to do it: Once in the morning, 30 minutes before breakfast and once in the afternoon, 30 minutes before lunch.

Frequently Asked Questions (FAQ)

1 .

The exact dosage for any person may vary according to a variety of different variables and circumstances.

Which brand of Garcinia Cambogia did Dr.Oz recommend?

Dr. Oz did not recommend any brands and he clearly mentioned that on his show.

2 . Which brand of Garcinia Cambogia is the best?

Although we traditionally use it in our fish curries, Garcinia Cambogia is not something I will be using for weight loss purposes anytime soon.

I’ve done my part to educate you guys about this product for weight loss but I don’t trust it, yet.

My opinions might change in the future if/when there are enough studies to support the claims on humans.

I’m not very satisfied with the before/after pictures and videos I’ve seen so far either.

Therefore I refuse to mention or link out to any Garcinia brands.

3. What should you look out for when buying Garcinia Cambogia?

  1. Strictly watch out for online scams. Don’t bother with the free trials from random websites and Facebook pages.
  2. Look for an FDA approved brand.
  3. Make sure it has at least 60% Hydroxycitric Acid (HCA) which is the active ingredient.
  4. And make sure it doesn’t have any fillers.

4 . Is Garcinia Cambogia safe for diabetics and pregnant women?

If you’re diabetic, pregnant or under any serious medications, please consult with your doctor before taking any weight loss supplements.

5 . What are the side effects of taking Garcinia Cambogia?

There’s been a lot of talks on this lately.

There have many claims of Garcinia causing Diarrhea, constipation, and insomnia.

Those, we can deal with.

However, there are also accusations of Garcinia causing liver damage, kidney and heart problems.

Now that’s something I wouldn’t want to risk myself with, which is another main reason why I’m not recommending any brands on here.

I’m still doing some research on the side effects of Garcinia Cambogia.

I’ll link my new post here when I’m done.

6 . Do you have any reliable before/after photos of Garcinia Cambogia and Apple Cider Vinegar diet results?

I have searched all over the internet and still haven’t come across any reliable before/after photos yet.

Some of these YouTube videos I saw on Garcinia reviews is just plain promotional ones.

Some have created a YouTube channel to post 1 video review of Garcinia Cambogia and that’s it.

No further updates or reliable photos whatsoever.

Even many of the comments left on these videos sound so fishy.

Request for you: If you have seen any reliable before/after photo results of Garcinia and Apple Cider vinegar diet anywhere, please send me the link so I can add it on here.

Photo credit will be given of course but I just can’t seem to find any that seem convincing.

7 . What about Apple Cider Vinegar for weight loss. Does it work for real?

As mentioned earlier, Apple Cider Vinegar also lacks much evidence from human trial studies.

However, I’ve definitely seen convincing before/after photos and videos of ACV diet.

I myself have a bottle of Braggs ACV and drink it whenever I’m bothered.

Another plus is that Apple Cider Vinegar side effects are definitely don’t sound scary compared to Garcinia.

8 . So is the Garcinia Cambogia and Apple Cider Vinegar diet a scam?

All I’m saying is, ask your doctor first.

And don’t bother with the free trials of Garcinia from the Internet because your card will be charged month after month.

Have you had any results with the Garcinia Cambogia and Apple Cider Vinegar diet?

Speak your mind in the comments below and share your experience with others.

Tell us if it worked for you or not and if you’ve had any side effects from this diet.

Can Garcinia Cambogia Help with Weight Loss?

Is there such a thing as a weight loss miracle drug?

Today’s market is full of “miracle drugs” and supplements that claim to help you drop pounds fast. It’s no wonder they fly off the shelves and into medicine cabinets across the country. TV personality Dr. Oz and others like him have showered praise on one of these products in particular: the controversial garcinia cambogia fruit.

Garcinia cambogia is a citrus fruit that grows in Southeast Asia. An extract from the fruit’s rind, hydroxycitric acid (HCA), has historically been used for cooking, but it has also been used for weight loss. You can buy garcinia cambogia online or at most health and supplement stores. It comes in pill form or as a powder. Let’s look at what, if anything, garcinia cambogia can do for your weight.

Advocates say that HCA, an organic acid, works by making you feel full, reducing your appetite, and affecting your metabolism. It’s this effect that has led many to herald it as a natural weight loss cure. Some say it may also help improve high cholesterol or enhance athletic performance.

The list of garcinia cambogia’s rumored benefits is a long one. It can be hard to determine the truth to the claims about its “miracle” properties. So, how do these health claims match up to scientific research?

1. Claim: Makes you feel full

Verdict: No evidence. An extensive review of the existing research on garcinia cambogia determined that there simply wasn’t conclusive evidence to suggest that the supplement or HCA had any effects on appetite and satiety. Although some rodent studies had positive results, no human studies could replicate them.

2. Claim: Lowers body weight

Verdict: No evidence. Existing evidence doesn’t prove that garcinia cambogia alone can facilitate weight loss. A 12-week, randomized, double-blind, placebo-controlled study published in JAMA found that the supplement didn’t help with significant weight loss or decrease in fat mass. Both the control and garcinia group were placed on high-fiber, low-calorie diets.

3. Claim: Speeds metabolism

Verdict: Some evidence. There is some evidence that supplementing with garcinia cambogia can influence fat metabolism. Several studies have found that both mice and humans experience an increase in fat metabolism after supplementing with HCA.

4. Claim: Enhances athletic performance

Verdict: Some evidence. Garcinia cambogia may increase the amount of time it takes to reach exhaustion during exercise, according to one study. Another study that used mice had similar results, showing that HCA enhanced endurance during running.

In addition to knowing how well it works, you’ll also want to know about a supplement’s potential side effects. Reported side effects for garcinia cambogia are mild. They include:

There are still other factors you should consider when deciding whether to use a supplement such as garcinia cambogia.

Drug interactions

As with all dietary supplements, HCA could interact with medications you take. Before starting HCA, be sure to talk to your doctor. Make sure they know about all medications you take, including prescription and over-the-counter drugs as well as other supplements.

Part of the allure of garcinia cambogia is the fact that it comes from a fruit, so it’s considered “natural.” However, this alone doesn’t make it a worthwhile supplement or even safe.

Even though we know this, we still don’t do something about it despite it being the cause of obesity that many of you are all complaining about.

The Food and Drug Administration (FDA) recommends using caution with products that claim to be quick fixes, promise fast weight loss, and use the term “natural.” Natural doesn’t necessarily mean safe. There are many poisonous plants that are natural, but can cause you serious harm. Many plants interfere with medication or are actually medications themselves.

More importantly, dietary supplements such as garcinia cambogia aren’t studied or approved by the FDA before they go on the market. Furthermore, supplement makers can claim that their products support normal body functions as long as they have a disclaimer stating that the FDA hasn’t evaluated those statements. In other words, supplements containing garcinia cambogia have not been rigorously tested for effectiveness, quality, purity, or safety.

Possible liver problems

In 2009, the FDA recalled a product that contained garcinia cambogia because it was found to cause liver problems. Research since then has been conflicted, with some citing a link between garcinia cambogia and liver damage and other research finding no link. You should discuss this risk with your doctor.

Long-term use

A review of studies on HCA found that no studies have effectively looked at garcinia cambogia use for longer than 12 weeks. That means there isn’t enough evidence to ensure that it’s safe and effective for long-term use.

The danger of scams

It’s free, so what’s the harm, right? Actually, those free trials for products that claim to help you lose weight fast can present more harm than you might think. From surprise shipping fees to extra charges for products you didn’t realize you ordered, these trials can end up costing you money. For information on how to avoid these scams, check out this page from the Federal Trade Commission.

“Miracle” weight loss solutions rarely live up to the hype. Even when there is scientific evidence of positive results, the results are often so mild and minimal that users are disappointed to learn they still have to exercise and control their eating in order to reap lasting and significant weight loss.

Dr. Oz has come under fire for promoting “miracle” weight loss products on his show. His claims got him into trouble with the U.S. Senate Subcommittee on Consumer Protection, Product Safety, and Insurance. There’s a reason that claims such as his about products with no clear evidence of effectiveness are taken seriously. Many consumers trust his opinion and could be misled into buying something that is, at best, a waste of time and money, and at worst, laden with potential side effects.

According to the FDA, any product, whether natural or man-made, that’s strong enough to work like a drug is capable of producing side effects. Before you add a dietary supplement to your weight loss plan, discuss it with your doctor. They can tell you if the product may be harmful or may be worth a try.

The best approach for weight loss is eating less fat and calories. Choose to eat whole, non-processed foods and burn calories with activity.