Garcinia cambogia problems
Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans.
Garcinia Cambogia: Does This Hyped Weight Loss Supplement Really Work?
Garcinia cambogia (GC) is a small, pumpkin-shaped fruit that grows in Southeast Asia and India. The key active ingredient found in the rind of garcinia cambogia is hydroxycitric acid (HCA), which some research suggests can help certain people lose weight. (1)
Currently, there are at least 14 separate HCA-containing products sold over-the-counter to consumers labeled as “garcinia cambogia.” Most people are drawn to the idea of using GC because of the potential that it can provide near-effortless, quick weight loss without the need to change someone’s overall diet or lifestyle very much.
GC itself is not a new product; in fact, it’s been consumed in parts of Asia for many years, although not for the purpose of losing weight. Since GC (traditionally also known as the Malabar tamarind) first began to gain popularity in the U.S. several years ago — after appearing frequently in the media and on popular health-related TV shows — sales have gone up dramatically. More and more people are purchasing this so-called “weight loss miracle drug” in hopes of losing stubborn body and stomach fat they’ve been struggling with for years.
But just like most other weight-loss supplements, pills and products, studies regarding GC’s effects and safety have been mixed. While there’s some evidence that HCA might be able to aid in weight loss even when someone does not exercise often or change his or her diet very much, there’s also concerns regarding serious side effects that can occur, including liver damage or failure, anxiety, fatigue, dizziness, and digestive problems.
Remember that just because GC is derived from a natural fruit doesn’t mean it’s always completely safe. So is garcinia cambogia ultimately worth trying? What’s the truth with this purported weight-loss supplement? Let’s take a look at how HCA works, in what situations GC might be helpful, and what adverse reactions are possible when using any type of weight loss drug.
Finally, it’s worth considering the fact that time and time again we see various fad diets and products publicized to help boost weight loss — but what really works in the end is living a healthy lifestyle long term.
Does Garcinia Cambogia Work? What the Studies Tell Us
Garcinia cambogia reviews, research results and weight loss testimonials have been mixed to say the least. By far the most well-publicized benefit of using garcinia cambogia is its ability to increase weight loss. Other claims that are commonly made about garcinia cambogia’s effects include:
- loss of appetite or less of a desire to eat than usual
- reduced cravings for unhealthy foods, such as sugar addiction
- a more positive mood (including feeling happier, more energetic and less tired)
- increased energy and concentration
- stabilized blood sugar levels
- improved bowel movements
- reduced joint pains
- improved cholesterol levels
- stronger desire to be physically active
Most of the claims above have not been backed by scientific studies, however some have. Let’s review the benefits of garcinia cambogia that actually have some merit and seem to be effective in some manner.
Some studies have found that garcinia cambogia might, in fact, be able to help with low amounts of fat loss, plus some of the other health concerns mentioned above, although its effectiveness is rarely strong or consistent. For example, research suggests that HCA works by blocking a certain enzyme called adenosine triphosphate-citrate-lyase, which contributes to the formation of fat cells. But studies comparing GC’s effects to controls have found that it might only increase weight loss by a mere one to two pounds on average.
These findings are exactly what researchers published in the Journal of Obesity in 2011. When they compared people who took garcinia cambogia extract to those who didn’t, the weight difference was very small (on average just about two pounds). Plus, it wasn’t even possible to conclude that GC was directly responsible for the additional pounds lost.
The meta-analysis reviewed results from 12 different trails involving GC and revealed a small, statistically significant difference in weight loss favoring use of garcinia cambogia products containing HCA slightly over use of a placebo. However, the analysis also found that some studies showed digestive side effects (“gastrointestinal adverse events”) were twice as common in HCA groups compared with placebo.
Results from various weight loss studies involving GC have been very mixed.
Screw that, I'm KEEPING all this extra fat in case you get the brilliant idea to make another person." With the Holidays approaching, and all the yummy yummy foods that go along with them, I'm tempted to throw in the towel, call it a day, and make peace with my muffin top and ass the size of Mt.
One study in the meta-analysis reported a significant decrease in fat mass in the HCA group compared with placebo, two studies reported a significant decrease in visceral fat/subcutaneous fat/total fat areas in the HCA group compared with placebo, but two other studies found no significant difference at all between HCA and placebo. A study that was published in the Journal of the American Medical Association found that GC used for 12 weeks (1,500 milligrams dosage) “failed to produce significant weight loss and fat mass loss beyond that observed with placebo.” (2)
The conclusion of the meta-analysis regarding garcinia cambogia? Researchers summed up their findings by saying that “the magnitude of the effects are small, and the clinical relevance is uncertain. Future trials should be more rigorous and better reported.” (3) The bottom line is that if you’re struggling to lose weight, GC likely won’t be the answer, according to trial and controlled studies.
Studies have also suggested that it’s possible that HCA found in garcinia cambogia can help lower someone’s appetite by increasing production of the neurotransmitter serotonin, which is associated with calm and happy feelings — and therefore, sometimes appetite suppression, less cravings and reduced desire for comfort foods. Animal studies show it might also help increase energy expenditure. (4)
Keep in mind, however, that this isn’t the case with all people, and there are other, potentially less risky ways to better manage your appetite and boost serotonin production (such as eating balanced meals with protein foods and healthy carbs at regular times throughout the day).
There’s some support for garcinia cambogia being able to improve cholesterol levels and lower high triglycerides. It might also be able to help raise HDL “good” cholesterol. It’s not safe for anyone already taking medications that affect cholesterol, however, and its effects don’t seem to be very reliable or strong.
Studies have found that GC has “no significant effect on anthropometric parameters, REE, triglycerides or glucose levels” but might have a small effect on lowering cholesterol. (5) Keep in mind that there are also plenty of other natural ways to improve cholesterol levels, including exercising and eating more dietary fiber from high-fiber foods like veggies, nuts, seeds and beans.
Finally, what about CG’s effects on blood sugar levels? Some evidence exists showing that garcinia cambogia can help control blood sugar by improving how cells take up glucose (sugar) to be used for energy. One way in which it might improve weight loss is through inhibition of pancreatic alpha amylase enzymes, changes in intestinal alpha glucosidase and alterations in fatty acid synthesis. This might be able to change how carbohydrates are metabolized. (6)
This might possibly help your body respond to insulin better, although it can raise the risk for having low blood sugar levels in some people, too. If you have a history of blood sugar swings, you’re prediabetic, diabetic or taking medications that alter insulin’s effects, GC might make your blood sugar drop dangerously low. While this doesn’t appear to happen in everyone who takes GC, it’s something else to consider and something to discuss with your doctor.
Potential Garcinia Cambogia Side Effects
While some people claim they don’t experience any side effects at all from using GC, others have had very different experiences. Here’s one disturbing account regarding the use of garcinia cambogia extract that you might not have heard about: It’s contributed to at least several patients winding up in the hospital with liver failure and needing emergency liver transplants.
A 2016 article published by the Transplantation Center at the Mayo Clinic reports that millions of Americans regularly use herbal supplements, often in pill form, but aren’t aware of their full effects. Many weight loss drugs pose potential hidden dangers and are “associated with hepatotoxicity and acute liver injury.” (7)
In the case of garcinia cambogia, it can easily be overused and is not very well-regulated. Some manufacturers recommend taking high doses multiple times per day, for example 30 to 60 minutes before every meal for eight to 12 weeks straight.
The physician will help to know whether the weight loss product is good for you and what amount of the bill can work for your case.
As we age, this become a viscous circle LOW NAD+ -> DISEASE & AGING -> LESS EXERCISE -> HIGHER BLOOD SUGAR -> LOWER NAD+ If you are over 40, and your fasting blood glucose level is >85mg/dl, you are pouring gasoline on the inflammation fire(63).
(8) Aside from liver damage, other garcinia cambogia side effects that can occur include:
- becoming fuzzy or weak
- fatigue and brain fog
- skin rashes
- an increase in catching colds/lower immune function
- dry mouth and bad breath
- digestive issues like nausea, trouble eating or diarrhea
Something else to consider about GC is the long list of its potential medical/drug interactions. Many people should avoid garcinia cambogia due to how it can affect other medications, pregnancy, nutrient levels, blood sugar and more. Garcinia cambogia can potentially interact badly with: (9)
- pregnancy and breastfeeding
- existing cases of liver or kidney damage
- medications that are taken to control asthma and allergies
- diabetes medications and insulin
- iron supplements (usually taken by people with anemia)
- pain medications
- medications used to control mental disorders like anxiety and depression
- statin drugs that lower cholesterol
- blood thinning drugs (like warfarin)
How Much Garcinia Cambogia Should You Take?
If you decide that you still want to try taking GC for weight loss or its other benefits, here’s what you need to know about dosage recommendations for products containing HCA:
- Studies using GC have used a wide range of doses, anywhere from one gram to 2.8 grams daily. Typical doses are ususally between 250–1,000 milligrams per day.
- Study durations have also varied widely, ranging from using GC between two to 12 weeks at a time.
- The optimal dose of HCA is currently still unknown. It’s not clear if a higher HCA dosage even means a higher bioavailability of HCA once consumed.
- There does seem to be a significant correlation between the dosage of HCA and body weight loss, meaning higher doses have slightly more effects.
- Garcinia cambogia continues to be the most widely used supplement in studies for providing HCA, however aside from GC, HCA can also be found in supplements made from the plant Hibiscus subdariffa.
- Because most studies have investigated the effects of GC taken for about eight weeks, researchers believe this is ultimately “too short a time to assess the effects of HCA on body weight.”
To err on the safe side, avoid buying garcinia cambogia “formulas” or “supplement blends,” which might fail to report all of the other ingredients included or accurate levels of HCA. Many proprietary formulas are made by manufacturers that only use a fraction of the active ingredient or standard dose to keep costs down. Always read labels and look for the words “pure garcinia cambogia” and “hydroxycitric acid (or HCA) extract” (this should be around 50 percent to 60 percent of the product). If you purchase a blend and see an ingredient listed without an amount, that can be a red flag that you don’t know exactly what you’re getting.
11 Weight Loss Methods That Really Do Work
In just about all studies involving garcinia cambogia, researchers note that it’s hard to tell if any demonstrated benefits (weight loss, reduced cholesterol, etc.) are really due to GC or are actually influenced by other factors like the subjects eating lower-calorie diets or exercising. It’s always possible for any supplement to cause a “placebo effect,” where subjects wind up changing their outlook and habits simply because they believe the product is helping them (even if it isn’t actually doing anything).
Another interesting fact that the Journal of Obesity meta-analsis reports is that most of the included studies “failed to indicate whether or not outcome assessors were blinded, and seven studies did not even specify who funded the garcinia cambogia studies.” While it’s possible that garcinia cambogia might help you lose an additional one to two pounds if you take it regularly, most experts don’t think it’s worth the money or the risk — especially considering its effects are so small and inconsistent.
Ultimately, taking weight loss supplements won’t teach you much about eating an overall healthy diet, finding ways to enjoy exercise, or practicing “intuitive eating” and managing cravings.
Our clear winner – Garcinia Cambogia Extra This particular brand, Garcinia Cambogia Extra, is certainly a market leader in both the USA and UK.
So what can you do to move in the right direction of losing weight safely? Weight loss efforts should always be realistic, safe and sustainable. Remember that the real goal is to reach a healthy weight and stay there for life. That’s why quick fixes and fad diets have been shown in studies to fail in the long run over 95 percent of the time.
Here are some of my favorite tips for losing weight using reliable methods that really work:
- Get good sleep! A lack of sleep (less than seven to nine hours nightly for most people) can mean a lack of weight loss.
- Eat more fiber: Adults need to aim for at least 25–30 grams daily from things like veggies, fruit, ancient grains, sprouted legumes and seeds.
- Use healthy fats: Coconut oil has natural fat-burning effects just like GC does, plus many more benefits like improving gut health, too. Other healthy fats that can help control your appetite include real olive oil, avocado, fats from grass-fed beef, nuts and seeds.
- Utilize adaptogen herbs: Adaptogen herbs like maca, ginseng and rhodiola can help control health conditions that can make it hard to lose weight (like high amounts of stress, thyroid issues, leaky gut, adrenal fatigue, cellular toxicity and candida).
- Don’t skimp on protein: Protein foods are satisfying and essential for building muscles. Regularly include proteins like cage-free eggs and wild-caught fish in your meals.
- Consume probiotics: Probiotic foods and supplements not only help balance improve digestive health, but they also balance hormones, raise immunity, control your appetite and play a part in weight control.
- Switch up your exercise routine: Try burst-training exercises and other forms of high intensity interval training (HIIT) to keep challenging your muscles, work in with a group, add in weight training, and relax with yoga in between workouts.
- Stand up more during the day: Sitting for long periods of time is associated with being overweight and a higher risk for obesity.
- Sneak more fitness into your day: Take the stairs, do body weight exercises at home. or try wearing a fitness tracker for motivation — try some of these exercise hacks.
- Schedule your workouts ahead of time: This makes it much more likely you’ll follow through.
- Useessential oils for weight loss: Natural oils including grapefruit, cinnamon and ginger oil can help control your appetite, hormones and digestive symptoms.
From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.
Garcinia cambogia problems
Garcinia cambogia is a small, sweet, purple fruit also known to some as Malabar tamarind. People who live near where it grows have used the fruit for hundreds of years because over time they have noticed certain beneficial properties after daily consumption.
Today, modern science has caught up to traditional wisdom about the human body. The result is an understanding of Hydroxycitric acid, which is able to be extracted from garcinia cambogia and used in nutritional supplements.
What is HCA Extract?
Hydroxycitric acid (HCA) is a derivative of citric acid that is extracted primarily from the rind of the garcinia cambogia fruit. This is primarily what offers benefits to the human body.
Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a safe, natural supplement for weight management. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. Previous studies in our laboratories have demonstrated the superior bioavailability of a novel calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax). Greater bioavailability of HCA-SX was observed when taken on an empty stomach (Source: An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management )
While HCA extract works as an appetite suppressant, other benefits may be seen when Hydroxycitric acid based supplements are taken on a daily basis.
What are the Benefits of Garcinia Cambogia?
The benefits of garcinia cambogia are plentiful.
This is simply because our bodies are made to crave high-calorie foods for survival.
Here are some of them.
- Slow Fat Production – One of the benefits of garcinia cambogia extract is that it helps slow down fat production in the body through working with the carbohydrates you eat during the day.
- More Efficient Metabolism -Hydroxycitric acid is thought to help the metabolism by helping control how carbohydrates are used by the body. Instead of excess carbs being turned into fat cells for later use they are used throughout the day. This can lead to loss of existing fat cells.
- Cholesterol Control – More studies need to be done in this area, but some people have suggested HCA extract causes carbohydrates to be converted into glycogen instead of fat and that this disrupts the production of triglycerides – the bad cholesterol.
- Increased Serotonin – HCA extract may also help with serotonin production in the body. When serotonin levels are low problems with anxiety, insomnia or even depression may develop. Serotonin is an essential hormone for happy and healthy humans.
- Appetite Suppression – Proper amounts of HCA extract can also work as a natural and effective way to suppress the appetite. This is one of the ancient uses of garcinia cambogia and one of the major reasons HCA supplements help people lose weight.
Other benefits of garcinia cambogia may exist, but the ones mentioned above are the ones most people are interested in HCA. TO LEARN MORE ABOUT WHERE TO PURCHASE GARCINIA CAMBOGIA CLICK THE LINK BELOW: (now available in US,UK,CA,NZ,AU)
Garcinia Cambogia for Weight Loss
While other benefits are known, there is no verdict on whether HCA extract can help with weight loss efforts. NYU Langone Medical Center has mentioned these HCA studies.
In an 8-week double-blind, placebo-controlled trial of 60 overweight individuals, use of HCA at a dose of 440 mg 3 times daily produced significant weight loss as compared to placebo.(Source: Thom E. Hydroxycitrate (HCA) in the treatment of obesity [abstract]. Int J Obes Relat Metab Disord. 1996;20(suppl 4):75.)
In contrast, a 12-week, double-blind, placebo-controlled trial of 135 overweight individuals, who were given either placebo or 500 mg of HCA (as Garcinia cambogia extract standardized to contain 50% HCA) 3 times daily, found no effect on body weight or fat mass. (Source: Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA.1998;280:1596-1600.) However, this study has been criticized for using a high-fiber diet, which is thought to impair HCA absorption. (Source: Badmaev V, Majeed M, Conte AA, et al. Garcinia cambogia for weight loss [letter]. JAMA. 1999;282:233-234.)
A 12-week double-blind trial of 89 individuals found that HCA had no effect on appetite.(Source: Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71:87-94.) Another study tested HCA to see if it could cause weight loss by altering metabolism, but no effects on metabolism were found.(Source: Kriketos AD, Thompson HR, Greene H, et al. (-)-Hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post-absorptive state. Int J Obes Relat Metab Disord . 1999;23:867-873.)
Many other studies have been conducted. Some of them have been on rats, but all the information has been useful to learn more about HCA extract and the ways in which it might affect the human body.
Does HCA Extract Have Side Effects?
As with anything ingested into the body, some people may develop side effects after taking supplements with HCA extract. If this is the case, consulting a doctor is recommended.
Here are some of the possible side effects of garcinia cambogia when taken in high doses.
- Gastrointestinal problems including intestinal pain, nausea, vomiting and diarrhea.
- Lower blood sugar levels
Additionally, some people may have an allergic reaction to Hydroxycitric acid. Many find the side effects associated with garcinia cambogia to be less than those that may occur when using other drugs to help with health or weight loss efforts.
What About Garcinia Cambogia Drug Interactions?
Currently, no information is known about possible interactions between HCA extract and other drugs.
This study examined the effects of Garcinia cambogia extract on mice over a period of 4 weeks.
This may change as further studies are conducted. Those who are considering taking a garcinia cambogia supplement and are taking other medications should consult a physician.
What is the Recommended Dose of HCA Extract?
A standard recommended dose of HCA extract will range from 200 mg to 1,000 mg up to three times per day. Taking more than 3,000 mg of Hydroxycitric acid in any 24 hour period is not recommended. For the most benefit, supplements should be taken a half hour before meals throughout the day. The exact dosage for any person may vary according to a variety of different variables and circumstances.
Garcinia Cambogia: Safe for Weight Loss?
In this Article
In this Article
In this Article
Garcinia cambogia, a tropical fruit also known as the Malabar tamarind, is a popular weight-loss supplement. People say it blocks your body's ability to make fat and it puts the brakes on your appetite. It could help keep blood sugar and cholesterol levels in check, too. You'll find it in bottles on the shelf at the store as well as mixed with other ingredients in diet products.
Does it live up to its hype? Maybe a little, but it might not be worth it.
How It Works
The active ingredient in the fruit's rind, hydroxycitric acid, or HCA, has boosted fat-burning and cut back appetite in studies. It appears to block an enzyme called citrate lyase, which your body uses to make fat. It also raises levels of the brain chemical serotonin, which may make you feel less hungry.
But actual weight loss results aren't impressive. A review published in the Journal of Obesityfound that people who took garcinia cambogia in studies lost about 2 pounds more than people who didn't take it. The reviewers couldn't say for sure that the weight loss was because of the supplement. It could have been from the lower-calorie diet and exercise programs the people in the studies typically followed. Better studies are needed to find out if HCA really helps people lose a lot of weight and keep it off.
Type 2 Diabetes and High Cholesterol
Garcinia cambogia may make it easier for your body to use glucose, the sugar your cells need for energy. Mice that got garcinia cambogia in one study had lower insulin levels than mice that didn't. That's another reason, besides weight loss, that people with diabetes are interested in it. However, if you're taking garcinia cambogia along with a medication to control your blood sugar, your glucose could get dangerously low.
Some research has found that garcinia cambogia can also improve cholesterol levels, lowering triglycerides and LDL (the "bad" cholesterol) and raising HDL (the "good" cholesterol). But you shouldn't use it if you're already on a prescription for your cholesterol.
Possible Side Effects
When you take garcinia cambogia, you might get:
In 2009, the Food and Drug Administration warned everyone to stop using a weight-loss product that contained garcinia cambogia because some people taking it got serious liver problems. The product had other ingredients, too, so it's not clear that garcinia cambogia was to blame. While some research suggests the supplement is safe for your liver, other research says no.
Garcinia cambogia may interact badly with:
You definitely don't want to use it when you're pregnant or nursing, or if you have kidney or liver problems. It is possible that manic symptoms may emerge as a side effect.
To Buy or Not to Buy
Since study results are mixed, you should talk with your doctor to help you decide if taking garcinia cambogia is a good idea. Even if it's safe, it may not help you lose much weight. It's probably wiser to spend your money on healthy food or an exercise DVD.
Onakpoya, I. Journal of Obesity, 2011.
NYU Langone Medical Center: "Weight Loss Aids."
Byrne, S. Consumer Reports, March 24, 2014.
Wielinga, P.Y. American Journal of Physiology, June 1, 2005.
Leonhardt, M. Nutrition, October 2004.
Hayamizu, K. Fitoterapia, April 2003.
Preuss, H. Nutrition Research, January 2004.
Preuss, H. Diabetes, Obesity and Metabolism, May 2004.
Preuss, H. International Journal of Clinical Pharmacology Research, February 2005.
Drugs.com: "Garcinia (hydroxycitric acid)."
Kim, Y. World Journal of Gastroenterology, Aug. 7, 2013.
Stohs, S. Toxicology Mechanisms and Methods, November 2010.