Garcinia cambogia results 1 week

Garcinia cambogia results 1 week
40 In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

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Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight.

The effect of a lessened appetite: unlike the topic of increased energy from taking GC, a reduced appetite is a proven benefit that has been studied extensively in many different trials.

3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia .

A healthy body can process nutrients better and burn fat faster than an unhealthy body.

It took me about 7 months, after buying a little over 2 dozen Garcinia Cambogia supplements!

J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

44.

She uses and has been using the Garcinia Cambogia fruit extract for her patients and saw increased weight loss of 2 to 3 times more than those taking a placebo.

Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.

45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.

47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.

48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.

49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

Copyright © 2009 Wolters Kluwer Health

Can Garcinia Cambogia Help with Weight Loss?

Is there such a thing as a weight loss miracle drug?

Today’s market is full of “miracle drugs” and supplements that claim to help you drop pounds fast. It’s no wonder they fly off the shelves and into medicine cabinets across the country. TV personality Dr. Oz and others like him have showered praise on one of these products in particular: the controversial garcinia cambogia fruit.

Garcinia cambogia is a citrus fruit that grows in Southeast Asia. An extract from the fruit’s rind, hydroxycitric acid (HCA), has historically been used for cooking, but it has also been used for weight loss. You can buy garcinia cambogia online or at most health and supplement stores. It comes in pill form or as a powder. Let’s look at what, if anything, garcinia cambogia can do for your weight.

Advocates say that HCA, an organic acid, works by making you feel full, reducing your appetite, and affecting your metabolism. It’s this effect that has led many to herald it as a natural weight loss cure. Some say it may also help improve high cholesterol or enhance athletic performance.

The list of garcinia cambogia’s rumored benefits is a long one. It can be hard to determine the truth to the claims about its “miracle” properties. So, how do these health claims match up to scientific research?

1. Claim: Makes you feel full

Verdict: No evidence. An extensive review of the existing research on garcinia cambogia determined that there simply wasn’t conclusive evidence to suggest that the supplement or HCA had any effects on appetite and satiety. Although some rodent studies had positive results, no human studies could replicate them.

2. Claim: Lowers body weight

Verdict: No evidence. Existing evidence doesn’t prove that garcinia cambogia alone can facilitate weight loss. A 12-week, randomized, double-blind, placebo-controlled study published in JAMA found that the supplement didn’t help with significant weight loss or decrease in fat mass. Both the control and garcinia group were placed on high-fiber, low-calorie diets.

3. Claim: Speeds metabolism

Verdict: Some evidence. There is some evidence that supplementing with garcinia cambogia can influence fat metabolism. Several studies have found that both mice and humans experience an increase in fat metabolism after supplementing with HCA.

4. Claim: Enhances athletic performance

Verdict: Some evidence. Garcinia cambogia may increase the amount of time it takes to reach exhaustion during exercise, according to one study. Another study that used mice had similar results, showing that HCA enhanced endurance during running.

In addition to knowing how well it works, you’ll also want to know about a supplement’s potential side effects. Reported side effects for garcinia cambogia are mild. They include:

There are still other factors you should consider when deciding whether to use a supplement such as garcinia cambogia.

Drug interactions

As with all dietary supplements, HCA could interact with medications you take. Before starting HCA, be sure to talk to your doctor. Make sure they know about all medications you take, including prescription and over-the-counter drugs as well as other supplements.

Part of the allure of garcinia cambogia is the fact that it comes from a fruit, so it’s considered “natural.” However, this alone doesn’t make it a worthwhile supplement or even safe. The Food and Drug Administration (FDA) recommends using caution with products that claim to be quick fixes, promise fast weight loss, and use the term “natural.” Natural doesn’t necessarily mean safe. There are many poisonous plants that are natural, but can cause you serious harm. Many plants interfere with medication or are actually medications themselves.

More importantly, dietary supplements such as garcinia cambogia aren’t studied or approved by the FDA before they go on the market. Furthermore, supplement makers can claim that their products support normal body functions as long as they have a disclaimer stating that the FDA hasn’t evaluated those statements. In other words, supplements containing garcinia cambogia have not been rigorously tested for effectiveness, quality, purity, or safety.

Possible liver problems

In 2009, the FDA recalled a product that contained garcinia cambogia because it was found to cause liver problems. Research since then has been conflicted, with some citing a link between garcinia cambogia and liver damage and other research finding no link. You should discuss this risk with your doctor.

Long-term use

A review of studies on HCA found that no studies have effectively looked at garcinia cambogia use for longer than 12 weeks. That means there isn’t enough evidence to ensure that it’s safe and effective for long-term use.

The danger of scams

It’s free, so what’s the harm, right? Actually, those free trials for products that claim to help you lose weight fast can present more harm than you might think. From surprise shipping fees to extra charges for products you didn’t realize you ordered, these trials can end up costing you money. For information on how to avoid these scams, check out this page from the Federal Trade Commission.

“Miracle” weight loss solutions rarely live up to the hype. Even when there is scientific evidence of positive results, the results are often so mild and minimal that users are disappointed to learn they still have to exercise and control their eating in order to reap lasting and significant weight loss.

Dr. Oz has come under fire for promoting “miracle” weight loss products on his show. His claims got him into trouble with the U.S. Senate Subcommittee on Consumer Protection, Product Safety, and Insurance. There’s a reason that claims such as his about products with no clear evidence of effectiveness are taken seriously. Many consumers trust his opinion and could be misled into buying something that is, at best, a waste of time and money, and at worst, laden with potential side effects.

According to the FDA, any product, whether natural or man-made, that’s strong enough to work like a drug is capable of producing side effects.

How garcinia cambogia diet works The hydroxycitric acid found in garcinia cambogia helps in weight loss by blocking fats and reducing your appetite.

Before you add a dietary supplement to your weight loss plan, discuss it with your doctor. They can tell you if the product may be harmful or may be worth a try.

The best approach for weight loss is eating less fat and calories. Choose to eat whole, non-processed foods and burn calories with activity.

Garcinia Cambogia Review: What You Need To Know

What's Inside This Guide

What’s all the fuss about? Well, this fruit rind extract has been touted as a revolutionary way to lose fat, tone up and suppress those cravings all in one natural supplement. With virtually no side effects, not like the awful buzz of too much caffeine or the nauseous feeling that many appetite suppressants can bring, this supplement was featured on the Dr Oz show, where his team of dedicated professionals explained just how this new pill could help the body to use its excess fat stores AND block the ability to build new fat reserves whilst reducing the stress level cortisone.

So if you’re like me, and hold your excess weight around your middle, this could be the perfect solution. But, the reviews out there have been mixed with some people seeing good results and others seeing very little indeed. Could it be that this secret ingredient is nothing more than a marketing ploy, or are we being cheated by unscrupulous companies while we chase our dreams of a tighter, more toned body? I thought I’d check out GCE from my favorite store and see whether this really is a miracle weight loss supplement.

What is Garcinia Cambogia?

Before we get to the supplement, dosage, side effects and so on, I thought I’d include a little information about the source of the supplement. Garcinia Cambogia Extract is taken from the rind of the malaban tamarind fruit, a fruit native to South East Asia and India. It has been used medicinally and in food preparation in its native home for centuries, because it has been said to boast the following properties:

  • Souring agent, used in traditional Indian or South East Asian hot and sour curries[1]
  • Used for bowel problems and rheumatism[2]
  • Contains HCA (Hydroxycitric Acid) which has been under the spotlight for weight loss
  • Food preservative, coloring agent and curing agent
  • Used as a carmative to prevent or expel excess gas formed in the GI tract[3]

How is Garcinia Cambogia linked to weight loss?

Garcinia Cambogia is said to boost weight loss in two different ways. Firstly, it blocks the enzyme in the liver that is responsible for the default function of converting sugar and carbs to fat. So instead of the fat cells getting plumper, GCE ‘plugs’ the fat cells and directs any sugar and carbs to the energy stores to be burnt off. The body is processing less fat and is under less stress, so less cortisol (the belly fat-creating hormone) is produced. The second way that it works is by sending signals to the brain that release more serotonin, our happy hormone, and this happiness stops us craving stress foods like sugar, carbs and salty foods and could have a positive impact on appetite suppression. For more information about how Garcinia Cambogia works, please visit my review of the Dr Oz show.

About Garcinia Cambogia and its clinical studies

Several clinical studies have been undertaken to assess the efficacy of Garcinia Cambogia. At the moment the research is a little patchy and generally the medical community recommends more testing. I’ve written a longer article focused on Garcinia Cambogia research and clinical trials, but have included a summary right here for you:

  • In a four week trial[4], 150 obese subjects saw a significant, dose-dependent decrease in weight, LDL cholesterol and triglycerides, and an improvement in good cholesterol
  • In an eight week trial[5], 40 subjects saw an increase in weight loss against the placebo group
  • In a 12 week trial[6] with a reduced calorie diet, the group lost nearly three times as much weight as the placebo group
  • In a 4 week trial[7] with a reduced calorie diet, 89 mildly overweight women saw an increase in weight loss against the placebo group, but noted no discernible change to appetite
  • In an eight week trial[8] with a low fat diet and at least 64oz water consumption per day, 54 overweight subjects lost an average of 11.2lb per person
  • In an eight week trial[9] with a low fat diet and moderate (three times per week) exercise, 60 obese subjects saw a greater weight loss and reduction of appetite than the placebo group
  • In a 16 week trial[10] with a low fat diet and moderate exercise, all 39 subjects saw a reduction in belly fat and gained none of it when given a placebo for four weeks

Go to any medical site and they will be the first to say that the supplement and ingredients such as HCA need a ton more research. It’s the same with any new herbal supplement I guess. But the research that’s taken place to date is certainly encouraging.

Is It Trusted And Safe To Use?

Genuine Garcinia Cambogia has been noted to have been ‘well tolerated’ for up to 12 weeks in human trials. Whilst this is a little vague, it means that there are generally few adverse reactions. Be sure to read the ‘who should take Garcinia Cambogia’ section below, for a list of who should avoid the supplement.

Who Is Garcinia Cambogia For?

Being a natural supplement, there are few people that should avoid taking Garcinia Cambogia. However, until more research has been undertaken, it is recommended that the following people should avoid it, or use it under medical supervision:

  • Patients with diabetes (high blood sugar) or hypoglycemia (low blood sugar) should avoid the supplement
  • Patients taking any medication that affect blood sugar should use Garcinia Cambogia under medical supervision
  • Patients with a high risk or history of rhabdomyolysis (a potentially fatal disease involving the degeneration of skeletal muscle) should use Garcinia Cambogia under medical supervision
  • Patients taking statins, should exercise caution as the combined medicines may increase the risk of rhabdomyolysis
  • Those with Alzheimer’s or other forms of dementia should avoid Garcinia Cambogia because of the theoretical possibility of forming acetylcholine in the brain
  • Those trying to conceive, pregnant or breastfeeding should avoid until further scientific evidence can be undertaken

For my full article on Garcinia Cambogia, including dosage and potential side effects, please click here.

My Favorite Garcinia Supplement?

Once you’ve decided that you want to try Garcinia Cambogia, the most important element is finding the right supplier. I’m not pushing any particular brand as it can be difficult to know whether a brand has been replicated and is not in fact genuine. I know of at least two well-known doctors/celebs that have had to put out alerts to their users saying that they are NOT endorsing a particular brand of Garcinia Cambogia, as there are a lot of unscrupulous companies out there selling fake or poor quality goods.

Sommige gebruikers ervaren vervelende bijwerkingen na het gebruik van garcinia cambogia.

I strongly recommend this brand at Amazon. After buying from them, I received great customer support and they were able to provide proof that their Garcinia Cambogia had been tested by a third party lab.

In general, I would say:

  • Use a trusted brand or store like Amazon
  • Read online reviews about your chosen brand carefully
  • Check the small print and reviews if you choose a ‘money back guarantee’ option, make sure that people that have returned the product for whatever reason have actually got refunds
  • Choose a supplement that has at least 50% HCA
  • Choose a supplement that contains minerals such as potassium and chromium, as these seem to have better reviews online
  • Choose a supplement that contains at least 600mg per day
  • Choose a supplement free from fillers or binders

Taking Garcinia Cambogia

I chose a supplement to try from my local and trusted health food store, and took 500mg three times per day.

**ULTRA-IMPORTANT** It’s critical that you take the supplements on an empty stomach, around 30-60 minutes before a meal. Food will interact with the supplement and reduce its efficacy. Also, I’m not sure of the science behind this, but I recall one study saw fewer results because the subjects were on a high fiber diet. Somehow that interfered, so eat a balanced healthy diet rich in vegetables, fruit, lean meats and good fats.

I took a supplement that also contained potassium, because I trusted Dr Oz!! I didn’t take any additional extracts as I wanted to see what this supplement did on its own.

So I took the pills three times a day, on an empty stomach. Unlike some supplements I’ve taken, I had no nausea or restlessness, you know like those buzzy caffeine pills. After drinking each one with a big glass of water, it’s common sense that an hour later you’ll be less hungry than you were, but my appetite was definitely more satiated than if I’d just had water.

The results were pretty much from day one, I was less hungry and ate slightly smaller meals, but the biggest effect I saw was in the type of food I wanted and the impact on my snacking. I know that my excess weight is down to my continual grazing, I eat pretty healthy but I can’t sleep unless I’ve had a full carb-loaded meal. And – ladies – at THAT time of the month I have an insatiable appetite for candy, chocolate, crisps, crackers…you name it! But in the three months that I took Garcinia Cambogia, my cravings all but disappeared. I ate when I was hungry (such a novelty for me, usually eating without even being aware of it) and saw the weight come off almost instantly.

I’ll be honest, we’re not talking total body transformations or anything. But I had stubborn belly fat that all types of exercise and diet had failed to get rid of for good. I guess I was carrying an extra 10lb over my ideal weight, and the majority of that was round my stomach. Garcinia Cambogia seemed to target that fat exclusively, which was a win-win for me as I didn’t want to lose any from my bust or butt. So in three months I lost around 9lb, but it was all from where I wanted it to go, and with no discernible change to my diet or exercise regime. I’m pretty fit so kept up the jogging and yoga, and it all seemed to work in harmony! I’ve now got a tighter waistline and am eating ‘mindfully’ for the first time in a hundred years!!

The million dollar question: Does Garcinia Cambogia work?

For me, it definitely worked. I saw reduced cravings to snack, and when I did eat, I was fuller faster, and on better quality foods. During my time of the month, I had little to no cravings. In fact, one time I went to the cinema and usually gorge on popcorn, but I only dipped in and out of this time (my husband was cursing me as he ended up eating it all!).

That said, it will only work if it’s a genuine product with a minimum 50% HCA. There are a lot of stores or vendors out there selling inferior products, which is why, in my mind, some people aren’t seeing the results they hoped.

What’s great about Garcinia Cambogia?

  • Natural supplement based on fruit used commonly for centuries
  • Helps curb cravings for sugar/salt/carbohydrates
  • Can boost weight loss, best used in conjunction with a healthy diet and moderate activity
  • No horrible side effects like nausea or headaches
  • Endorsed by doctors, models and celebrities
  • Cheap, compared to many supplements

Anything not so great?

  • Some people have seen minimal results – I say you can’t eat everything and expect to lose weight!
  • Some people have seen no results – I keep saying it, but check you’re buying from a reputable source and that the supplement contains at least 50% HCA
  • Can’t be used by those with blood sugar issues (see my full Side Effects of Garcinia Cambogia report)

What others are saying about Garcinia Cambogia?

I’ve researched many sources of Garcinia Cambogia users to bring you a consolidation of the most frequent opinions. In summary, there have been a lot of people ripped off and for them, they’ve lost money and not seen any results. For those that have bought reputable brands, they’ve seen moderate results which have been optimized by a healthy diet and moderate activity. Here are the views:

  • “I dropped from 13.5% to 11% body fat in time for my beauty show.”
  • “I have been taking for 2 weeks and have lost 8lbs, I love it!”
  • “I have been taking Garcinia Cambogia for 2 months and have lost 10lbs.”
  • “I have been taking it for two weeks and don’t see an extraordinary change, just 3lbs in two weeks.”
  • “After 1 week, I was surprised by the dramatic results…my energy levels were up and I wasn’t even hungry…after the fifth week my results were shocking. I lost an unbelievable 23lbs.”
  • “I’ve been taking it for a week and gained 3lbs!”
  • “Never buy from a site that appeared 1 hour after the Dr Oz show.”
  • “Took for a month and no weight loss”
  • “I purchased mine at GNC after talking to the sales person. She said her husband lost 60 lbs but she has only lost 10, but she admitted he works out more.”

My opinion: A summary review of Garcinia Cambogia

It’s not often you can find something that helps you lose weight without changing your diet or exercise habits, but Garcinia Cambogia seems to do just that. I made no changes but saw a drop of 9lb over my trial period, I’m now down to my ideal weight and have lost it all from my belly. I bought from a store I trusted, and went for a supplement with over 50% HCA, and it really worked, particularly in curbing my grazing and snacking. As with any diet supplement, there will be rogue dealers out there so always check reviews before buying online, use recommended products or buy via your trusted store. Here’s to the body you’ve always wanted!

[4] Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

[5] Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt.