Garcinia cambogia women's diet

Garcinia cambogia women's diet
Possible liver problems In 2009, the FDA recalled a product that contained garcinia cambogia because it was found to cause liver problems.

Garcinia Cambogia: Safe for Weight Loss?

In this Article

In this Article

In this Article

Garcinia cambogia, a tropical fruit also known as the Malabar tamarind, is a popular weight-loss supplement. People say it blocks your body's ability to make fat and it puts the brakes on your appetite. It could help keep blood sugar and cholesterol levels in check, too. You'll find it in bottles on the shelf at the store as well as mixed with other ingredients in diet products.

Does it live up to its hype? Maybe a little, but it might not be worth it.

How It Works

The active ingredient in the fruit's rind, hydroxycitric acid, or HCA, has boosted fat-burning and cut back appetite in studies. It appears to block an enzyme called citrate lyase, which your body uses to make fat. It also raises levels of the brain chemical serotonin, which may make you feel less hungry.

But actual weight loss results aren't impressive. A review published in the Journal of Obesityfound that people who took garcinia cambogia in studies lost about 2 pounds more than people who didn't take it. The reviewers couldn't say for sure that the weight loss was because of the supplement. It could have been from the lower-calorie diet and exercise programs the people in the studies typically followed. Better studies are needed to find out if HCA really helps people lose a lot of weight and keep it off.

Type 2 Diabetes and High Cholesterol

Garcinia cambogia may make it easier for your body to use glucose, the sugar your cells need for energy. Mice that got garcinia cambogia in one study had lower insulin levels than mice that didn't. That's another reason, besides weight loss, that people with diabetes are interested in it. However, if you're taking garcinia cambogia along with a medication to control your blood sugar, your glucose could get dangerously low.

Some research has found that garcinia cambogia can also improve cholesterol levels, lowering triglycerides and LDL (the "bad" cholesterol) and raising HDL (the "good" cholesterol). But you shouldn't use it if you're already on a prescription for your cholesterol.

Possible Side Effects

When you take garcinia cambogia, you might get:

In 2009, the Food and Drug Administration warned everyone to stop using a weight-loss product that contained garcinia cambogia because some people taking it got serious liver problems. The product had other ingredients, too, so it's not clear that garcinia cambogia was to blame. While some research suggests the supplement is safe for your liver, other research says no.

Garcinia cambogia may interact badly with:

You definitely don't want to use it when you're pregnant or nursing, or if you have kidney or liver problems. It is possible that manic symptoms may emerge as a side effect.

To Buy or Not to Buy

Since study results are mixed, you should talk with your doctor to help you decide if taking garcinia cambogia is a good idea. Even if it's safe, it may not help you lose much weight. It's probably wiser to spend your money on healthy food or an exercise DVD.

Onakpoya, I. Journal of Obesity, 2011.

NYU Langone Medical Center: "Weight Loss Aids."

Byrne, S. Consumer Reports, March 24, 2014.

Wielinga, P.Y. American Journal of Physiology, June 1, 2005.

Leonhardt, M. Nutrition, October 2004.

Hayamizu, K. Fitoterapia, April 2003.

Preuss, H. Nutrition Research, January 2004.

Preuss, H. Diabetes, Obesity and Metabolism, May 2004.

Preuss, H. International Journal of Clinical Pharmacology Research, February 2005. "Garcinia (hydroxycitric acid)."

Kim, Y. World Journal of Gastroenterology, Aug. 7, 2013.

Stohs, S. Toxicology Mechanisms and Methods, November 2010.

Clouatre, D. World Journal of Gastroenterology, Nov. 28, 2013.

Marquez, F. Critical Reviews in Food Science and Nutrition, Issue 7, 2012.

Medscape: "Leukotriene Receptor Antagonists."

Don’t believe the LIES about Garcinia Cambogia

Popular, but…

For more than a decade Garcinia Cambogia has been included in various weight loss products, but exploded in popularity in 2012 when Dr Julie Chen talked about it on the Dr Oz TV show.

Unfortunately, there is an avalanche of faulty information about Garcinia Cambogia on the web that we attempt to clean up here.

What The Research Says?

Several studies on rats have demonstrated significant weight loss, belly fat reduction, and lowered blood glucose levels (4, 5, 6).

We looked at all the randomized, double-blind clinical studies on humans. Some we excluded were either too short (2 weeks), used too small a dose, or had other flaws such as a low fat, high carb diet which researchers believe had a negative impact on the results.

This chart shows the results from the most relevant clinical studies on Garcinia Cambogia, encompassing 307 participants (7,8,9,10).

All of these were Double Blind,Randomized Controlled Trials, with subjects given Garcinia Cambogia or Placebo over 8-12 weeks.

The average for these 4 studies was 4.1 pounds lost vs 1.7 for those taking Placebo.

It should be noted that studies #3 and 4 used the highest dosages of 2800 mg daily, and showed the greatest amount of weight loss compared to placebo.

Studies #1 and 2 showed the least amount of weight loss benefit, and also used the lowest amount of Garcinia Cambogia, at 1200 mg per day.

Conclusion: The average for the 4 relevant clinical studies on humans showed weight loss of 3 pounds more than placebo. Studies that used higher doses of HCA recorded more weight loss.

Choose a Reputable Supplier

What brand of Garcinia Cambogia should you Buy?

You really need to read the label. Many brands are pushing inferior products. If they don’t show you the label, chances are they are trying to push you some crappy, useless stuff and don’t want you to realize it until you take it and don’t get any results.

Always Look for the HCA!

HCA, or hydroxycitric acid, is the active ingredient. You need to make sure it has at LEAST 60% HCA in it – Higher is better. Also check to make sure they don’t use a lot of added ingredients – especially if they’re hard to read, nearly impossible to pronounce ingredients.

What We Recommend

We’ve looked at all the leading brands sold on Amazon. There are several that are good, and dozens that are garbage.

Reasons why we recommend it:

  • Has 90% HCA!
  • No filler ingredients – all natural only
  • 600mg per capsule
  • Has been PROVEN to be effective
  • Has NO additives, fillers and other low-quality ingredients

Garcinia Cambogia

90% HCA 600 mg 90 V-caps

Garcinia Cambogia (3pk)

90% HCA 600 mg 90 V-caps

Pharmaceutical Companies Hate Garcinia Cambogia

According to this article in Washington Post, it cost between $800 million and $2.6 BILLION to bring a new prescription drug to market.

Once they start clinical trials, the pharmaceutical company only has 20 years of patent protection to recoup that cost, so they have to charge exorbitant prices to make that back and pay their shareholders a good return on their investment.

Of course they don’t want potential customers to think a natural product that cost a tiny fraction of what they charge can be effective at all.

Hence pharmaceutical manufacturers often fund research studies they hope will cast the competition in a bad light.

Dietary fiber is thought to interfere with HCA, which could have inhibited weight loss in the HCA group.

A few million dollars to fund a study on a competitor is nothing compared to the billions it cost to develop a drug.

For example, this meta-review that examines existing clinical studies on Garcinia Cambogia is funded by GlaxoSmithKline, the manufacturer of the prescription weight loss pill Orlistat, marketed under the name Alli.

For reference, Alli cost $60 for 120 capsules! The literature claims it can block 25% of the fat you eat from being absorbed.

Not surprisingly, the research they pay for often finds mixed results, with some studies showing positive effects for Garcinia Cambogia and some not.

The academic editor for that meta review was also the lead author for a few of the studies that found Garcinia to be ineffective. He also was the lead author for several studies that showed positive results for Orlistat (1,2,3).

Conclusion: Big Pharma spends hundreds of millions of $$$ funding research to cast doubt on the effectiveness of natural weight loss products like Garcinia Cambogia.


Garcinia Cambogia is somewhat unique in that there are 2 pathways the HCA utilizes to help with weight loss

1. It May Help Reduce Hunger

Studies with rats have shown those given Garcinia Cambogia tend to eat less than those in the control group(11, 12).

How it works isn’t fully known, but those studies seem to indicate it increases levels of serotonin in the brain. (13, 14).

Likewise, some clinical studies with humans has shown it tends promote feeling of satiety (fullness), so you eat less. (15, 16, 17, 18, 19).

Serotonin is the “feel good” hormone that promotes feelings of satisfaction and is well known to be an appetite suppressant. (20).

Those studies are in contrast to some others that found no benefit for suppressing appetite vs those given placebo. (21, 22, 23, 24). Its not clear why studies have shown such a difference and more study is needed.

Conclusion: Some studies have shown garcinia cambogia increases serotonin to suppress appetite, but there have been other studies that could not replicate this effect.

2. It May Block Fat Production and Reduce Belly Fat

The effect HCA has on fatty acids in the bloodstream is the most important factor in its ability to aid weight loss.

Human and animal studies has shown HCA helps lower levels of triglycerides in the blood, reducing the oxidative stress throughout the body. (25, 26, 27, 28, 28).

It is even more attractive as a weight loss aid as it helps reduce belly. (29).

Another study gave moderately obese individuals 2,800 mg of garcinia cambogia daily for eight weeks (30).

After completion, participants had dramatically lower markers of metabolic disease such as:

  • 6.3% LOWER Total cholesterol levels
  • 12.3% LOWER LDL (the “bad”) cholesterol levels
  • 10.7% HIGHER HDL (the “good”) cholesterol levels
  • 8.6% LOWER Blood triglycerides

This is due to the inhibition of the enzyme citrate lyase, which signals the production of fat in the body (32, 33, 34, 35, 36).

By inhibiting citrate lyase, garcinia cambogia is thought to slow down or block fat production in the body. This may reduce blood fats and lower the risk of weight gain, two major disease risk factors (37).

Conclusion: Garcinia cambogia blocks the production of new fats in the body, and has been shown to lower cholesterol levels and blood triglycerides in overweight people.


Animal and test-tube studies suggest that garcinia cambogia may also have some anti-diabetic effects, including (38, 39, 40):

  • Decreasing insulin levels
  • Decreasing leptin levels
  • Reducing inflammation
  • Improving blood sugar control
  • Increasing insulin sensitivity

Garcinia cambogia may also have benefits for the digestive system. Animal studies have suggested it helps protect against stomach ulcers and reduce damage to the inner lining of the digestive tract (41, 42).

However, these effects need to be studied further before firm conclusions can be drawn.

Conclusion:Garcinia Cambogia may help lower blood sugar levels and increase insulin sensitivity to combat diabetes

Side Effects

Generally Recognized as Safe (GRAS)

Garcinia Cambogia is recognized as GRAS by the FDA, meaning it has

been adequately shown to be safe under the conditions of its intended use.

There have been several studies to test the effectiveness of these products and in these controlled quantities there were no significant side effects.

This meta-analysis examined all published research on Garcinia Cambogia, and found garcinia to be free from any major side effects when taken at dosages up to 2800 mgs per day (with 60% HCA)

At least 15 clinical studies involving approximately 900 patients document mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Who Should Not Take


It IS safe for most people. But there are a few cases where you wouldn’t want to take it:

Garcinia Cambogia boosts serotonin levels in the brain (which triggers the satisfied, full feeling that helps suppress appetite).

For this reason, it is not advised for patients with neurological disorders such as Alzheimers, Parkinsons, or other forms of dementia.


Dr Harry Preuss is a researcher and pathologist at Georgetown University past president of the American College of Nutrition who has led 2 of the studies on HCA that showed the best results (43,44).

You have to take the right dose of the right product, and you have to take it properly.

– Dr Harry Preuss

The 4 studies that were included in the meta-analysis referenced above noted that 1 to 2.8 grams daily were used in testing, and that 2.8 grams seemed more effective (45)

Different studies that have been performed to focus on side effects found no major side effects at dosages up to 2.8 grams daily (46).

Dosage recommendations from those studies are:

  • 500 to 1000mg capsules
  • 70% or higher HCA
  • 3 times a day
  • 30-60 minutes before meals
  • taken with 8 ounces of water

70% HCA means that the manufacturer has standardized the extract to be 70% Hydroxycitric Acid by volume.

50-60% was the highest purity commercially available until recently, so has been the standard used for testing.

The higher percentage provides more total HCA per capsule, but is not more effective otherwise.

In other words, the higher HCA % is not “better”, you just need less of it.

For proper dosage, you should lower the quantity if you use a product with HCA % higher than the 60% used in studies.

For example, the maximum recommended dosage of 3 grams per day of a 60% HCA product would yield 1800 mg of pure HCA – the same as 2 grams of 90% HCA.


3,000 mg x 60% HCA = 1800mg pure HCA

2,000 mg x 90% HCA = 1800mg pure HCA

With any popular diet product, there are lots of scams that sell crappy product at ridiculous prices, and some that disappear with your money.

It is becoming more common now with Garcinia, so beware, and read some of our reviews of brands like Ultra, Extreme, Purely Inspired, Miracle, Whole Body, Natural, and Pure Garcinia Cambogia.

Amazon is super convenient, and great at making sure you get what you order.

That Said, Below Are The Top Brands We Picked As We Found Them To Be Highly Reputable And Effective.

In first tests, it was possible to notice prevention against panic attacks in healthy people due to weight loss, for example.

But they don’t do anything to ensure the quality of a product.

Any brand that just popped up yesterday and will be gone tomorrow is NOT concerned with quality.


There are now dozens of new “Brands” of Garcinia Cambogia sold on Amazon that just make up a name and throw a label on some garbage product. And, they LIE about what is in the bottle!

The following quote is directly from the Dr Oz website where they warn about such deceptive marketing.

Sold Only On Web? Beware!

Our experience at with herbal weight loss supplement suggests that you are more likely to get a bad product if it is sold only on web. Products sold in stores can also have problems (we have uncovered many), but this is less likely, probably because there is an extra layer of scrutiny by stores when deciding what they will carry, and the consequences of selling a bad product may be greater, for example, for a national retail chain, than a small web business. Products sold in mail catalogs also tend to have fewer problems than those sold only on the web. If you’re interested a supplement sold exclusively online, be particularly careful.

This doesn’t mean all products sold on Amazon are bad. It just warns that products sold ONLY on Amazon are a much higher risk for being very poor quality.

Conclusion: Beware any Brand or Product that is sold exclusively online and not in a brick in mortar store. Those that exist only on Amazon and do not even have a website of their own are very likely to sell a very poor quality product.

Choose a Reputable Supplier

What brand of Garcinia Cambogia should you Buy?

You really need to read the label. Many brands are pushing inferior products. If they don’t show you the label, chances are they are trying to push you some crappy, useless stuff and don’t want you to realize it until you take it and don’t get any results.

Always Look for the HCA!

HCA, or hydroxycitric acid, is the active ingredient. You need to make sure it has at LEAST 60% HCA in it – Higher is better. Also check to make sure they don’t use a lot of added ingredients – especially if they’re hard to read, nearly impossible to pronounce ingredients.

What We Recommend

We’ve looked at all the leading brands sold on Amazon. There are several that are good, and dozens that are garbage.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.


Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .


Information regarding safety and efficacy in pregnancy and lactation is lacking.


The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.


Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis.

Now many of you would ask what if it goes out of control?

11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G.

Rheumatism and bowel complaints are treated with a decoction of the fruit rind.

cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.


Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37


In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42


Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49


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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

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The extract in the capsules is taken from the rind, where there are great amounts of HCA (Hydroxycitric Acid) – the key ingredient to making you lose weight.

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