Garcinia extract dose

Garcinia extract dose
One past study done by researchers based All these beneficial results are attributed to the high presence of HCA in Garcinia Cambogia extract.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running.

While some research suggests the supplement is safe for your liver, other research says no.

30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

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11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice.

Infatti, questo fantastico prodotto naturale, utilizzabile grazie alla commercializzazione di vari tipi di integratori, inizialmente riduce l’appetito grazie alla sua azione di soppressore e, successivamente, agisce come bruciatore delle cellule adipose, consentendo una perdita del peso e il raggiungimento del desiderato obiettivo.

Ripeness is gauged by the full development of color and slight softening.

J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.

45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.

47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.

48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.

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Other Names:

Brindal Berry, Brindle Berry, Cambogia binucao, Cambogia gemmi-guta, Garcinia affinis, Garcinia Cambogi, Garcinia cambogia, Garcinia gummi-guta, Garcinia sulcata, Gorikapuli, Kankusta, Kudam puli, Malabar Tamarind, Mangostana cambogia, Tamarinie.

See All Names Brindal Berry, Brindle Berry, Cambogia binucao, Cambogia gemmi-guta, Garcinia affinis, Garcinia Cambogi, Garcinia cambogia, Garcinia gummi-guta, Garcinia sulcata, Gorikapuli, Kankusta, Kudam puli, Malabar Tamarind, Mangostana cambogia, Tamarinier de Malabar, Vrikshamla.

GARCINIA Overview Information

Garcinia is a small to medium-sized tree that grows in India and Southeast Asia. The fruit rind contains the chemical hydroxycitric acid (HCA) and is used to make medicine. Don't confuse Garcinia with Garcinia hanburyi (gamboge resin).

How does it work?

Garcinia contains the chemical hydroxycitric acid (HCA). Developing research suggests that HCA might prevent fat storage, control appetite, and increase exercise endurance; however, whether these effects occur in humans is unclear.

GARCINIA Uses & Effectiveness

Insufficient Evidence for:

  • Exercise performance. Taking a chemical compound found in Garcinia called hydroxycitric acid (HCA) might increase how long untrained women are able to exercise. However, it does not seem benefit men in the same way.
  • Weight loss. Research on the effect of Garcinia on weight loss is inconsistent. Some research shows that taking Garcinia extract that contains 50% hydroxycitric acid (HCA) for 8-12 weeks doesn't decrease fat breakdown or energy expenditure in overweight people. However, other research suggests that it might improve weight loss when taken for 12 weeks. Taking a specific Garcinia product containing 60% HCA (Super CitriMax InterHealth Nutriceuticals) by mouth in three doses daily 30 to 60 minutes before meals for 8 weeks, together with a healthy diet, seems to improve weight loss more than just diet alone. But other research shows that adding this specific Garcinia product to cereal bars or tomato juice and consuming them before lunch and dinner for 2 weeks does not improve weight loss. Reasons for the inconsistent results might be the dose, duration of treatment, or formulation of Garcinia extract that was used.
  • Joint pain.
  • Treating worms and parasites.
  • Emptying the bowel.
  • Severe diarrhea (dysentery).
  • Other conditions.
More evidence is needed to rate the effectiveness of garcinia for these uses.
GARCINIA Side Effects & Safety

Garcinia is POSSIBLY SAFE for most people when taken by mouth for 12 weeks or less. Long-term safety is unknown. Garcinia can cause nausea, digestive tract discomfort, and headache.

Special Precautions & Warnings:

GARCINIA Interactions

We currently have no information for GARCINIA Interactions

GARCINIA Dosing

The appropriate dose of garcinia depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for garcinia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. View abstract.

Jena, B. S., Jayaprakasha, G. K., Singh, R. P., and Sakariah, K. K. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric.Food Chem. 1-2-2002;50(1):10-22. View abstract.

Kriketos, A. D., Thompson, H. R., Greene, H., and Hill, J. O. (-)-Hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post-absorptive state. Int J Obes.Relat Metab Disord. 1999;23(8):867-873. View abstract.

Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis. 2007 Oct;39(10):953-5. View abstract.

Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. View abstract.

Badmaev V, Majeed M, Conte AA. Garcinia cambogia for weight loss. JAMA 1999;282:233-4; discussion 235. View abstract.

Chuah LO, Yeap SK, Ho WY, et al. In vitro and In vivo toxicity of Garcinia or hydroxycitric acid: a review. Evid Based Compl Alt Med 2012;2012:197920. View abstract.

Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. View abstract.

Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 7;14(45):6999-7004. View abstract.

Firenzuoli F, Gori L. Garcinia cambogia for weight loss. JAMA 1999;282:234; discussion 235. View abstract.

García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. View abstract.

Hasegawa N. Garcinia extract inhibits lipid droplet accumulation without affecting adipose conversion in 3T3-L1 cells. Phytother Res 2001;15:172-3. View abstract.

Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. View abstract.

Ishihara K, Oyaizu S, Onuki K, Lim K, et al. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice.

This of course depends on the ‘brand’ of GCE used, and whether or not it is taken at the right times and coupled with a healthy lifestyle.

J Nutr 2000;130:2990-5. View abstract.

Kovacs EM, Westerterp-Plantenga MS, Saris WH. The effects of 2-week ingestion of (--)-hydroxycitrate and (--)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight. Int J Obes Relat Metab Disord 2001;25:1087-94. View abstract.

Lim K, Ryu S, Nho HS, et al. (-)-Hydroxycitric acid ingestion increases fat utilization during exercise in untrained women. J Nutr Sci Vitaminol (Tokyo) 2003;49:163-167. View abstract.

Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. View abstract.

Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. View abstract.

Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94. View abstract.

Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav 2000;71:87-94. View abstract.

Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. View abstract.

Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180. View abstract.

Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. View abstract.

Schaller JL. Garcinia cambogia for weight loss. JAMA 1999;282:234; discussion 235. View abstract.

Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010 Aug;69(8):188-90. View abstract.

Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. View abstract.

Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. View abstract.

Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91. View abstract.

Westerterp-Plantenga MS, Kovacs EMR. The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. Int J Obesity 2002;26:870-2. View abstract.

Garcinia cambogia

Garcinia Cambogia is a fruit that is known to enhance the culinary experience of food, and enhances satiety from a meal (possibly by enhancing the flavor experience). Its usage as a fat burner does not appear to extend to humans.

This page features 48 unique references to scientific papers.

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Summary of Garcinia cambogia

Primary Information, Benefits, Effects, and Important Facts

Garcinia Cambogia (Malabar Tamarind) is a small fruit that has some traditional usage to enhance the culinary experience of a meal, but beyond that has limited medicinal usage. It is a very good source of hydroxycitric acids (structurally related to citric acid, a sour flavorant) and one of the isomers, known as (-)-Hydroxycitric acid, is thought to help in weight control.

The mechanism of action is inhibiting an enzyme called Citric acid lysase which is required in the synthesis of fatty acids, known as de novo lipogenesis. At least in rats, evidence of suppressed de novo lipogenesis has been noted and oral consumption of (-)-Hydroxycitric acid appears to reliably reduce food intake and body weight (the latter to a degree where food intake cannot explain all the observed effects)

Studies in humans, for the most part, fail to replicate this; this may be related to less actual activity of de novo lipogenesis in humans and a much higher level in rats. Some isolated studies do note weight loss, but it appears to be quite variable and unreliable. Many studies also do report subjective appetite decrease, but tend to record dropout rates (how often people leave the study due to being unable to maintain the diet protocol) rather than food intake; even then the benefits are still unreliable and sometimes not present.

Although there is some limited potential for (-)-Hydroxycitric acid as a weight loss aid, the magnitude of effect is quite low (up to 2kg over 3 months) and the benefit is unreliable; making it hard to recommend this compound as a fat burner or anti-obesity agent.

The ONLY Guide You Need for Garcinia Cambogia

Things to Know

Also Known As

Gambooge, Pazham Puzhi, Bitter Kola, Malabar tamarind, (-)-Hydroxycitric acid, HCA, Hydroxycitric acid

Do Not Confuse With

Hoodia gordonii (another ineffective appetite suppressant)

Is a Form Of

Caution Notice

How to Take

Recommended dosage, active amounts, other details

Standard dosing of Garcinia Cambogia and its bioactive, (-)-Hydroxycitric acid, is 500mg of (-)-Hydroxycitric acid taken 30-60 minutes prior to a meal and usually taken at up to three different meals daily.

It is unsure if this is the ideal dose since human studies usually fail to find a benefit with any dosage.

Confused about supplements?

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects garcinia cambogia has on your body, and how strong these effects are.

Studies Excluded from Consideration

Excluded due to being confounded with White Kidney Bean Extract and Inulin [1]

Confounded with a lot of things [3]

Scientific Research

Table of Contents:

  1. 1 Sources and Composition
    1. 1.1 Sources
    2. 1.2 Composition
  2. 2 Pharmacology
    1. 2.1 Serum
  3. 3 Neurology
    1. 3.1 Appetite
    2. 3.2 Neuroprotection
  4. 4 Cardiovascular Health
    1. 4.1 Lipoproteins and Cholesterol
    2. 4.2 Blood
  5. 5 Interactions with Fat Mass
    1. 5.1 Mechanisms
    2. 5.2 Adipokines
    3. 5.3 Weight Regain
    4. 5.4 Weight Gain
    5. 5.5 Weight Loss
  6. 6 Interactions with Glucose Metabolism
    1. 6.1 Glycogen
  7. 7 Interactions with Hormones
    1. 7.1 Testosterone
    2. 7.2 Estrogen
  8. 8 Interactions with Organ Systems
    1. 8.1 Kidney and Bladder
    2. 8.2 Testes
  9. 9 Safety and Toxicology
    1. 9.1 General
    2. 9.2 Mutagenicity
    3. 9.3 Case Studies

The ONLY Guide You Need for Garcinia Cambogia

1 Sources and Composition

1.1. Sources

Garcinia Cambogia (of the family Guttiferae), sometimes also referred to as Pazham Puzhi [4] , Malabar tamarind, [5] or Bitter Kola [6] is a plant that bears small fruits (5cm diameter) and has traditionally been used as a food additive to both enhance the flavor of food products and to enhance satiety following consumption. [5] Very limited traditional medicine usage extends to gastrointestinal complications. [5]

1.2. Composition

The fruits of Garcinia Cambogia tend to contain:

Citric Acids (causative of taste and flavor) at 10-30% dry weight, of which a large segment consists of hydroxycitric acids (HCAs); [7] HCAs come in four isomers, (-)-Hydroxycitric acid, (+)-Hydroxycitric acid, (-)-Allo-HCA, and (+)-Allo-HCA [5]

Guttiferone I-K [8] [9] and M-N [8]

The polyisoprenylated benzophenones Garcinol [9] and Isogarcinol [10]

Xanthochymol (highly variable between 113.66+/-0.75ng/mL fruit and undetectable) and Isoxamthochymol (23.26ng/mL or lower); about 2.52-2.56ng/mL of both in the leaves [11] [12]

Cambogin, an isomer of isoxanthochymol [10] and Camboginol [13] (88.2mg/g of the fruit methanolic extract; undetectable in aqueous extracts, seeds, or stems) [10]

Isoxanthochymol (16.6mg/g methanolic extract; none in aqueous extract of the stems/seeds) [10]

It should be noted that currently marketed (-)-Hydroxycitric Acid supplements tend to be calcium/potassium salts of (-)-HCA containing about 60% (-)-HCA by weight. [5]

2 Pharmacology

2g of (-)-HCA salts given to 4 human participants on an empty stomach resulting in plasma levels of 0.8μg/mL within 30 minutes leading up to plasma levels of 8.4μg/mL at two hours with a variable peak between 4.7 and 8.4μg/mL. [14] The authors hypothesized that if absorption was complete and evenly distributed, it would have resulted in a serum peak of 46μg/mL (based on the participant's body weight and 25% body fat), a preliminary guess at the bioavailbility of (-)-Hydroxycitric acid following oral administration would be 10-18%. [14]

The bioactive has been demonstrated to appear in the blood following oral administration, and may have bioactivity

3 Neurology

3.1. Appetite

In freshly prepare rat brain slices, (-)-Hydroxycitric acid (salt form; 60% HCA by weight) was able to inhibit serotonin reuptake into rat corticol slices by 20% (300uM concentration), which was outperformed by fluoxetine (100uM) plus clomipramine (10uM) which inhibited 30% of uptake; oddly, no inhibition was noted with 1000uM (1mM) of (-)-Hydroxycitric acid.

The fruit is from Indonesia, but it can also be found in Asia, Africa, and India.

[15] The increased bioavailability of serotonin is thought to be related to appetite suppressing effects of supplemental (-)-Hydroxycitric acid. [15]

Another possible mechanism is the thought to be leptin related. One rat study (that failed to find reductions in food intake or weight after 4 weeks of 3.3% (-)-Hydroxycitric acid) noted that serum levels of insulin and leptin decreased, which was thought to be in response to leptin-mimetic actions (not established). [16]

May inhibit the reuptake of serotonin (not yet confirmed in a living model)

In rats who have had the reductions in feed intake quantified, it has been reported to be reduce by 13.7% (0.2% feed intake), 26.7% (2% feed intake) and 25.6% (5% feed intake) in male rats with similar reductions in female rats, with significant reductions of feed intake in this study only occurring 46 days after consumption (earliest) or 74 days (all tested doses). [17]

In rats, appears to suppress food intake

3.2. Neuroprotection

Garcinia Cambogia has once been associated with reduced brain oxidation and pathology of neurodegeneration, but was said to be working vicariously through reduced food intake and body weight (with the study concluding that the state of obesity and a high fat diet impairs neural function). [18]

4 Cardiovascular Health

4.1. Lipoproteins and Cholesterol

A study in rates using 200-400mg/kg Garcinia Cambogia seeds (ethanolic extract) noted slight but statistically significant increases in LDL-C (the 'bad' cholesterol) with decreases in HDL-C, vLDL-C, and triglycerides. [6]

In obese humans given 2g of Garcinia Cambogia (60% Hydroxycitric acid) for 10 weeks, there were no significant alterations in ApoA1, ApoB, Phospholipids, Free Fatty acids, or the Artherogenic Index. [19]

One study on blood lipids also noted a small but significant increase in red blood cell count, indicative of erythropoeisis. [6] One review [5] suggests this may be due to the iron content of the seeds, or perhaps an increase in testosterone from the polyphenolic component.

5 Interactions with Fat Mass

5.1. Mechanisms

(-)-Hydroxycitric acid appears to be a competitive inhibitor of the enzyme adenosine triphosphate-citrate (pro-3S)-lyase (a shorter designation is ATP Citrate Lysase), [20] which is an enzyme in the biosynthetic pathway of fatty acids (de novo lipogenesis) and its inhibition results in suppressed formation of Acetyl-CoA from Citrate and less substrate for fatty acid synthesis in vitro. [21] The (+)- isomer of Hydroxycitric acid does not have this same inhibitory potential, and is instead a substrate of the enzyme.

Can inhibit an enzyme in the de novo lipogenesis pathway that mediates fatty acid synthesis from non-fat sources, thought to inhibit the synthesis and deposition of fatty acids via this mechanism

The relevance of this pathway to humans may be in question, as human capacity for de novo lipogenesis does exist but tends to be less than that of rodents that are commonly used in research. [22]

In regards to this mechanism of action, there may be species-related differences

5.2. Adipokines

2g of Garcinia Carmbogia for 10 weeks was associated with a reduction in the adipokine Adipsin (19%) without significantly influencing Adiponectin or Leptin. [19]

5.3. Weight Regain

There have been a few studies assessing weight regain. One in rats who were semi-starved (less than 10g of food daily for 10 days) who were subsequently randomized to receive normal diets of standard chow, sucrose loaded chow, glucose loaded chow or a high glucose fat diet with half of each group recieving 3% (-)-Hydroxycitric acid (85mmol/kg) and then followed for 10 days (so overall, 8 groups of which 4 had HCA supplementation). [23] This study noted that the inevitable weight regain in these rats was attenuated with HCA supplementation in all groups except normal chow, and only reached significance with glucose and glucose+fat diet groups; this was in part due to less food intake, and appeared to decrease the food efficiency ratio with all groups except standard chow. [23] This trial style was replicated with the glucose group, and it was noted that food intake was suppressed for a short time, and although there was indication that de novo lipogenesis may have been inhibited there was no significant suppressive effect on body weight regain. [24]

Two rat studies suggesting that Garcinia can reduce the amount of weight regained during a period of overfeeding after a period of low caloric intake

5.4. Weight Gain

A rat trial in which rats were fed an obesogenic diet for 15 days with 2% added (-)-Hydroxycitric acid (as trisodium conjugate) noted that the food efficiency ratio decreased to 60% of control, and that body weight gain was suppressed to approximately half (49%) of control; food intake also decreased 17%, which would have contributed to the observed reduction in weight. [25]

One rat study suggesting that Garcinia can attenuate the rate of weight gain

5.5. Weight Loss

A study in human subjects using 2g Garcinia cambogia (60% Hydroxycitric acid) for 10 weeks in 86 overweight adults failed to find significant differences in weight loss or food intake. [19] One study using 2400mg of Garcinia cambogia daily divided before meals noted that while active treatment lost more weight from a low calorie diet than placebo over a period of 12 weeks (3.7+/-3.1kg weight loss rather than 2.4+/-2.9kg) that there were no reported differences in appetite. [26]

One of the larger and better controlled studies on the matter noted that, 1000mg of Garcinia Camboga (50% HCA by weight) taken before the three main meals of a low calorie diet given to overweight but otherwise healthy adults (of which placebo was also placed on) and then followed for 12 weeks failed to find any significant differences in dropout rates, weight loss, or adverse effects relative to placebo. [27]

Studies done in humans using isolated Garcinia Cambogia have mixed results on fat loss, with the one study reporting benefit showing relatively low magnitude of benefit (1.3kg more than placebo over 3 months, with very high variability)

In 40 persons with a BMI between 27.5-39 (mostly obese) given 100mg Garcinia Cambogia (confounded with inclusion of 400mg Inulin and 200mg White Kidney bean extract) before each of the three major meals for a period of 12 weeks, with both placebo and supplemental group being advised to diet (1200kcal), noted that weight loss in the diet and supplement group was greater (4% body weight over 12 weeks) than the diet and placebo group (not statistically significance). [1] Dropouts from the study were also greater in placebo (6) than supplement (1) groups. [1] One other study that uses Garcinia Cambogia but is highly confounded with other nutrients also noted beneficial effects on weight loss. [3]

The studies that are associated with both weight loss and Garcinia Camboga are confounded with many ingredients, and the observed effects on fat loss cannot be attributed to Garcinia itself

Several reviews on the efficacy of Garcinia Cambogia suggest no significant benefit for weight loss in human interventions. [28] [29] [30] [31] [32] The rather frequent inclusion of Garcinia Cambogia in review articles relative to the lack of interventions may be related to the popularity of the supplement.

Numerous review articles assessing the evidence of Garcinia Cambogia conclude that there is no significant benefit of this compound in humans

6 Interactions with Glucose Metabolism

6.1. Glycogen

When 500mg (-)-Hydroxycitric acid is consumed alongside 2g/kg carbohydrate post exercise in humans, a slight increase in the rate of glycogen resynthesis occurs. [33]

7 Interactions with Hormones

7.1. Testosterone

1667.3mg of Garcinia Cambogia for 12 weeks (1000mg (-)-Hydroxycitric acid) failed to find significant influences on serum testosterone. [34]

7.2. Estrogen

1667.3mg of Garcinia Cambogia for 12 weeks (1000mg (-)-Hydroxycitric acid) failed to find significant influences on serum estrogens (estrone and estradiol). [34]

8 Interactions with Organ Systems

8.1. Kidney and Bladder

While ingestion of a high-fat or high-sucrose diet is able to increase serum levels of urea and creatinine (thought to be indicative of kidney impairment), coingestion of Garcinia Cambogia at 50mg/kg is able to effectively normalize the increases in creatinine and urea. [35]

Oral ingestion of the leaves from Garcinia Cambogia at 100-200mg/kg of either the water extract or ethanolic extract was able to increase urine output in the range of 36-72% (ethanolic) or 17-39% (aqueous), both of which underperformed to 20mg/kg injections of the reference drug furosemide. [36]

The leaves of Garcinia may have weak diuretic properties

One study noted that oral consumption of 778-1244mg/kg bodyweight of (-)-Hydroxycitric acid to rats for up to 93 days was associated with testicular toxiciy with lower doses not associated with testicular toxicity. [37] This study has been critiqued, [38] where the lack of assurance on the salt form was questioned and the fact that the No Obervable Adverse Effect Limit (NOAEL) of 389mg/kg in rats is still 10-16 fold higher than the typical recommended serving for humans. [38]

A lone report on testicular toxicity with high dose (-)-Hydroxycitric acid consumption; may not be relevant to human supplementation doses

9 Safety and Toxicology

9.1. General

Acute (14 day) administration of 5000mg/kg bodyweight (-)-Hydroxycitric Acid to albino rats of both genders (small sample size of 10) was not associated with any mortality or clinical signs of toxicology.

Make sure the manufacturing facility is certified GMP lab Garcinia Cambogia Extra created to meet all the criteria of an effective and reliable weight loss supplement, Garcinia Cambogia Extra has 60% HCA, contains no calcium, fillers, nor binders, and manufactured in FDA registered, cGMP certified lab!

[15]

Studies that do not inhernetly design themselves to assess toxicology but nevertheless use (-)-Hydroxycitric acid supplementation have also failed to find any toxicity associated with 3% of the rat diet for 5 days [24] or 10 days, [23] or up to 5% of the feed for 90 days. [39]

Currently, the human trials cited in Examine do not report any adverse effects that occur in the treatment groups (using Garcinia Camboga) to a greater degree than placebo.

No observable toxicity in rats or humans following oral ingestion at this moment in time

9.2. Mutagenicity

A preliminary study assessing the mutagenicity of (-)-Hydroxycitric acid on five strains of Salmonella typhimurium (TA98, TA100, TA102, TA1535, and TA1537) up to 5000mcg/plate failed to find evidence of DNA damage or mutagenicity associated with (-)-Hydroxycitric Acid [40] and a lack of genotoxicity was repeatedly demonstrated elsewhere with the Ames test; [40] [41] this latter study noted that (-)-HCA increased the amount of micronucleated polychromatic erythrocytes (MNPCEs) after intravenous administration, which is though to be genotoxic. [41] The conclusion of this has been criticized for being suggestive of genotoxicity while the study had some design flaws (used DSMO alongside (-)-HCA while control got water, DMSO not being recommended for this test [42] ) and no LD50 test of the method of administration prior to genotoxicity testing. [43]

In rats given up to 5% (-)-Hydroxycitric acid in feed intake for a period of 90 days, there does not appear to be any significant DNA fragmentation in the liver or testicles. [17]

There does not appear to be any influence of the bioactive (-)-Hydroxycitric acid on DNA fragmentation or genomic damage; unlikely to be carcinogenic

9.3. Case Studies

There are numerous case reports of hepatoxicity associated with a supplement known as 'Hydroxycut' which touts Garcinia Cambogia as the main active ingredient, [44] [45] although it has been argued that there is no evidence to suggest a link to (-)-Hydroxycitric acid due to inclusion of many ingredients. [46]

In a patient on chronic Monteluskat treatment who then consumed two supplements, fatality occurred; it was thought that Montelukast interacted advesely with one of the many compounds consumed but causative could not be linked. [47]

One reported case of Rhabdoyolysis associated with a dietary supplement of which contained Garcinia Cambogia has been noted, although Ma Huang (plant source of ephedrine) is a large confound alongside chromium and Guarana. [48]

Due to the usage of Garcinia in fat burners, there has been reported connections between Garcinia and adverse effects; there is currently no evidence to assume a direct link between the compounds

Scientific Support & Reference Citations

References

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