Garcinia extract

Garcinia extract
The minimum recommended daily dosage is 1,500 milligrams.

Garcinia extract

Garcinia Cambogia: The Newest, Fastest Fat Burner?

If you’ve been trying to lose weight, you’ve most likely heard of garcinia cambogia – a fruit believed to hold the very key to healthy weight loss. If you’ve never considered using garcinia cambogia extract supplements for weight loss before, then it’s about time you should.

Garcinia cambogia is a tropical fruit found in the countries of Southeast Asia. People who live in the region have long used this incredible tiny fruit to make dishes more filling. Western scientists who encountered the fruit, decided to study its weight loss abilities and discovered that the rind contains massive amounts of HCA – which is short for Hydroxycitric Acid.

HCA is the very key ingredient why garcinia cambogia supplements are making a massive name in the weight loss industry today. HCA is known to suppress appetite and prevent your body from making fat tissues – leading to fast and effective weight loss done through the most natural and safest way possible.

Why Is Garcinia Cambogia So Popular?

In the world of natural weight loss solutions, no other name surpasses garcinia cambogia as the most recommended and most effective natural weight loss supplement in the market.

Garcinia cambogia came into national consciousness through the efforts of Dr. Oz – the most famous doctor on TV today. Immensely impressed by recent scientific research, he dubbed garcinia cambogia as the “holy grail” to beat weight gain.

Immediately after featuring the supplement in his show, tens of thousands of individuals around the country decided to use the supplement to combat excess weight and keep the weight away.

And because it’s 100% all-natural and truly effective in weight loss even without the help of diet and exercise, garcinia cambogia has become the best selling and most recommended natural weight loss supplement in the industry today.

How Garcinia Cambogia Extract Helps for Weight Loss

Garcinia cambogia supplements work through the mechanisms of HCA – the very key ingredient that makes the extract a powerful weight loss solution.

It somehow uses your own body’s chemicals to combat weight gain, giving you natural and healthy weight loss from the inside out.

HCA works through two main mechanisms: Suppression of Appetite and Fat Production Prevention.

1. Suppression of Appetite

One of the main reasons why people can’t seem to lose weight is because they can’t control what they eat, and the volume of food that they eat. It’s a sad fact that appetite is one of the hardest things to control.

HCA helps you lower your food consumption by making your body feel full even when you’ve only had little to eat. This means you get to say goodbye to cravings such as sweets and salty foods, say goodbye to emotional and binge eating and say hello to smaller portions each and every time.

HCA helps you eat only the amount of food that your body needs, and nothing more – helping you lose excess weight and maintain a healthy daily calorie intake.

2. Fat Production Prevention

Whenever you eat carbohydrates, your body converts them into energy. Now when you don’t use this energy, a certain enzyme named citrate lyase converts these carbohydrates into fat tissues – giving you not just weight gain, but nasty fat tissues that go to your stomach, arms, thighs, and all the other parts of the body that accumulate fat.

When you take HCA, this enzyme will no longer work. HCA inhibits citrate lyase and the entire process of fat production will no longer exist – giving you effective fat production prevention done in the most natural way possible.

Helping you ward off cravings and fat production, garcinia cambogia is an all-natural supplement giving your body natural methods to combat excess fat and weight.

Studies that Prove Garcinia Cambogia’s Effectiveness

Several studies on garcinia cambogia can be found at the website of the US National Library of Medicine National Institutes of Health.

One of these studies was done by Downs, BW, Bagchi M, and others in November of 2005.

The study, entitled “ Bioefficacy of a novel calcium-potassium salt of HCA ,” proved that HCA, together with potassium and calcium, results to increased serotonin availability, reduced appetite, increased fat oxidation, increased blood lipid levels, reduced body weight, and the modulation of a number of obesity regulatory genes.

Another study was done on May 2004 – Preuss, HG, and others conducted a randomized, double-blind, placebo-controlled human clinical study in Elluru, India over the period of 8 weeks. The subjects were 60 moderately-obese individuals aged 21 to 50 years old.

This group of people were divided into 3: Group 1 took HCA, Group 2 took niacin-bound HCA, and Group 3 took placebo pills.

At the end of the study, the researchers discovered that both Groups 1 and 2 had reduced body weight, reduced body mass index, reduced food intake, and reduced total cholesterol.

Preuss and others then concluded that optimal doses of HCA can serve as a potentially safe and effective weight loss formula that can facilitate effective reductions in both excess body weight and body mass index.

Does It Have Any Side Effects?

There have been reports of nausea and stomach upsets from actual users, but severe side effects have not occurred. Users who do experience side effects may have used products that contained other ingredients aside from HCA and/or potassium and calcium.

Because garcinia cambogia is so popular, literally tens of thousands of garcinia cambogia products have popped up in the market. And because you don’t need to have a prescription to buy one, it’s so easy to purchase these supplements from just about anywhere and from anyone.

It’s very important that you equip yourself with the knowledge and qualifications of what a top quality and effective garcinia cambogia product is so you know you’re getting an authentic product that’s safe and most of all, effective.

Are Garcinia Cambogia Products Made the Same?

The answer to this is no. There are literally thousands of garcinia cambogia products out there but only a small number really do stand out in the market.

Dr. Oz emphasized the importance of certain requirements of a top quality garcinia cambogia supplement. When you look for a product, the following qualifications are a definite must:

  • The product must contain at least 50% pure HCA concentration
  • It must have the label “HCA” or “Garcinia Cambogia” on the bottle
  • It must contain 100% all natural ingredients
  • Each capsule must have at least 500mg of dosage
  • The product must be made in FDA-registered and GMP-certified laboratories

If a certain garcinia cambogia brand adheres to these requirements, then you know you have a top quality product that’s safe, healthy, and truly effective.

Where to Buy Garcinia Cambogia

The supplements we recommend here are available through retail stores or exclusively online. One of our bestselling and top recommended products is Garcinia Cambogia Extra , satisfying thousands of users!

Meeting all these qualifications is Garcinia Cambogia Extra – is made in FDA registered and cGMP-certified laboratories, ensuring you that each and every capsule satisfies the manufacturing, testing, and quality assurance of Good Manufacturing Practices.

With 60% HCA in every dosage, Garcinia Cambogia Extra is one the top garcinia cambogia product to try today.

They are only available through their official website, so head to Garcinia Cambogia Extra and choose from these 3 packages:

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ALL ORDERS come with 30-DAY MONEY BACK GUARANTEE! Garcinia cambogia is a dosage-based supplement, which means the more you use, the more weight you’ll lose. Choose from these 3 package options and start your weight loss journey today.

Garcinia cambogia

Garcinia Cambogia is a fruit that is known to enhance the culinary experience of food, and enhances satiety from a meal (possibly by enhancing the flavor experience). Its usage as a fat burner does not appear to extend to humans.

This page features 48 unique references to scientific papers.

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Summary of Garcinia cambogia

Primary Information, Benefits, Effects, and Important Facts

Garcinia Cambogia (Malabar Tamarind) is a small fruit that has some traditional usage to enhance the culinary experience of a meal, but beyond that has limited medicinal usage. It is a very good source of hydroxycitric acids (structurally related to citric acid, a sour flavorant) and one of the isomers, known as (-)-Hydroxycitric acid, is thought to help in weight control.

The mechanism of action is inhibiting an enzyme called Citric acid lysase which is required in the synthesis of fatty acids, known as de novo lipogenesis. At least in rats, evidence of suppressed de novo lipogenesis has been noted and oral consumption of (-)-Hydroxycitric acid appears to reliably reduce food intake and body weight (the latter to a degree where food intake cannot explain all the observed effects)

Studies in humans, for the most part, fail to replicate this; this may be related to less actual activity of de novo lipogenesis in humans and a much higher level in rats. Some isolated studies do note weight loss, but it appears to be quite variable and unreliable. Many studies also do report subjective appetite decrease, but tend to record dropout rates (how often people leave the study due to being unable to maintain the diet protocol) rather than food intake; even then the benefits are still unreliable and sometimes not present.

Although there is some limited potential for (-)-Hydroxycitric acid as a weight loss aid, the magnitude of effect is quite low (up to 2kg over 3 months) and the benefit is unreliable; making it hard to recommend this compound as a fat burner or anti-obesity agent.

The ONLY Guide You Need for Garcinia Cambogia

Things to Know

Also Known As

Gambooge, Pazham Puzhi, Bitter Kola, Malabar tamarind, (-)-Hydroxycitric acid, HCA, Hydroxycitric acid

Do Not Confuse With

Hoodia gordonii (another ineffective appetite suppressant)

Is a Form Of

Caution Notice

How to Take

Recommended dosage, active amounts, other details

Standard dosing of Garcinia Cambogia and its bioactive, (-)-Hydroxycitric acid, is 500mg of (-)-Hydroxycitric acid taken 30-60 minutes prior to a meal and usually taken at up to three different meals daily.

It is unsure if this is the ideal dose since human studies usually fail to find a benefit with any dosage.

Confused about supplements?

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects garcinia cambogia has on your body, and how strong these effects are.

Studies Excluded from Consideration

Excluded due to being confounded with White Kidney Bean Extract and Inulin [1]

Confounded with a lot of things [3]

Scientific Research

Table of Contents:

  1. 1 Sources and Composition
    1. 1.1 Sources
    2. 1.2 Composition
  2. 2 Pharmacology
    1. 2.1 Serum
  3. 3 Neurology
    1. 3.1 Appetite
    2. 3.2 Neuroprotection
  4. 4 Cardiovascular Health
    1. 4.1 Lipoproteins and Cholesterol
    2. 4.2 Blood
  5. 5 Interactions with Fat Mass
    1. 5.1 Mechanisms
    2. 5.2 Adipokines
    3. 5.3 Weight Regain
    4. 5.4 Weight Gain
    5. 5.5 Weight Loss
  6. 6 Interactions with Glucose Metabolism
    1. 6.1 Glycogen
  7. 7 Interactions with Hormones
    1. 7.1 Testosterone
    2. 7.2 Estrogen
  8. 8 Interactions with Organ Systems
    1. 8.1 Kidney and Bladder
    2. 8.2 Testes
  9. 9 Safety and Toxicology
    1. 9.1 General
    2. 9.2 Mutagenicity
    3. 9.3 Case Studies

The ONLY Guide You Need for Garcinia Cambogia

1 Sources and Composition

1.1. Sources

Garcinia Cambogia (of the family Guttiferae), sometimes also referred to as Pazham Puzhi [4] , Malabar tamarind, [5] or Bitter Kola [6] is a plant that bears small fruits (5cm diameter) and has traditionally been used as a food additive to both enhance the flavor of food products and to enhance satiety following consumption. [5] Very limited traditional medicine usage extends to gastrointestinal complications. [5]

1.2. Composition

The fruits of Garcinia Cambogia tend to contain:

Citric Acids (causative of taste and flavor) at 10-30% dry weight, of which a large segment consists of hydroxycitric acids (HCAs); [7] HCAs come in four isomers, (-)-Hydroxycitric acid, (+)-Hydroxycitric acid, (-)-Allo-HCA, and (+)-Allo-HCA [5]

Guttiferone I-K [8] [9] and M-N [8]

The polyisoprenylated benzophenones Garcinol [9] and Isogarcinol [10]

Xanthochymol (highly variable between 113.66+/-0.75ng/mL fruit and undetectable) and Isoxamthochymol (23.26ng/mL or lower); about 2.52-2.56ng/mL of both in the leaves [11] [12]

Cambogin, an isomer of isoxanthochymol [10] and Camboginol [13] (88.2mg/g of the fruit methanolic extract; undetectable in aqueous extracts, seeds, or stems) [10]

Isoxanthochymol (16.6mg/g methanolic extract; none in aqueous extract of the stems/seeds) [10]

It should be noted that currently marketed (-)-Hydroxycitric Acid supplements tend to be calcium/potassium salts of (-)-HCA containing about 60% (-)-HCA by weight. [5]

2 Pharmacology

2g of (-)-HCA salts given to 4 human participants on an empty stomach resulting in plasma levels of 0.8μg/mL within 30 minutes leading up to plasma levels of 8.4μg/mL at two hours with a variable peak between 4.7 and 8.4μg/mL. [14] The authors hypothesized that if absorption was complete and evenly distributed, it would have resulted in a serum peak of 46μg/mL (based on the participant's body weight and 25% body fat), a preliminary guess at the bioavailbility of (-)-Hydroxycitric acid following oral administration would be 10-18%. [14]

The bioactive has been demonstrated to appear in the blood following oral administration, and may have bioactivity

3 Neurology

3.1. Appetite

In freshly prepare rat brain slices, (-)-Hydroxycitric acid (salt form; 60% HCA by weight) was able to inhibit serotonin reuptake into rat corticol slices by 20% (300uM concentration), which was outperformed by fluoxetine (100uM) plus clomipramine (10uM) which inhibited 30% of uptake; oddly, no inhibition was noted with 1000uM (1mM) of (-)-Hydroxycitric acid. [15] The increased bioavailability of serotonin is thought to be related to appetite suppressing effects of supplemental (-)-Hydroxycitric acid. [15]

Another possible mechanism is the thought to be leptin related.

Studies that Prove Garcinia Cambogia’s Effectiveness Several studies on garcinia cambogia can be found at the website of the US National Library of Medicine National Institutes of Health.

So, in short, consult a doctor before adding these supplements to your diet.

One rat study (that failed to find reductions in food intake or weight after 4 weeks of 3.3% (-)-Hydroxycitric acid) noted that serum levels of insulin and leptin decreased, which was thought to be in response to leptin-mimetic actions (not established). [16]

May inhibit the reuptake of serotonin (not yet confirmed in a living model)

In rats who have had the reductions in feed intake quantified, it has been reported to be reduce by 13.7% (0.2% feed intake), 26.7% (2% feed intake) and 25.6% (5% feed intake) in male rats with similar reductions in female rats, with significant reductions of feed intake in this study only occurring 46 days after consumption (earliest) or 74 days (all tested doses). [17]

In rats, appears to suppress food intake

3.2. Neuroprotection

Garcinia Cambogia has once been associated with reduced brain oxidation and pathology of neurodegeneration, but was said to be working vicariously through reduced food intake and body weight (with the study concluding that the state of obesity and a high fat diet impairs neural function). [18]

4 Cardiovascular Health

4.1. Lipoproteins and Cholesterol

A study in rates using 200-400mg/kg Garcinia Cambogia seeds (ethanolic extract) noted slight but statistically significant increases in LDL-C (the 'bad' cholesterol) with decreases in HDL-C, vLDL-C, and triglycerides. [6]

In obese humans given 2g of Garcinia Cambogia (60% Hydroxycitric acid) for 10 weeks, there were no significant alterations in ApoA1, ApoB, Phospholipids, Free Fatty acids, or the Artherogenic Index. [19]

One study on blood lipids also noted a small but significant increase in red blood cell count, indicative of erythropoeisis. [6] One review [5] suggests this may be due to the iron content of the seeds, or perhaps an increase in testosterone from the polyphenolic component.

5 Interactions with Fat Mass

5.1. Mechanisms

(-)-Hydroxycitric acid appears to be a competitive inhibitor of the enzyme adenosine triphosphate-citrate (pro-3S)-lyase (a shorter designation is ATP Citrate Lysase), [20] which is an enzyme in the biosynthetic pathway of fatty acids (de novo lipogenesis) and its inhibition results in suppressed formation of Acetyl-CoA from Citrate and less substrate for fatty acid synthesis in vitro. [21] The (+)- isomer of Hydroxycitric acid does not have this same inhibitory potential, and is instead a substrate of the enzyme.

Can inhibit an enzyme in the de novo lipogenesis pathway that mediates fatty acid synthesis from non-fat sources, thought to inhibit the synthesis and deposition of fatty acids via this mechanism

The relevance of this pathway to humans may be in question, as human capacity for de novo lipogenesis does exist but tends to be less than that of rodents that are commonly used in research. [22]

In regards to this mechanism of action, there may be species-related differences

5.2. Adipokines

2g of Garcinia Carmbogia for 10 weeks was associated with a reduction in the adipokine Adipsin (19%) without significantly influencing Adiponectin or Leptin. [19]

5.3. Weight Regain

There have been a few studies assessing weight regain. One in rats who were semi-starved (less than 10g of food daily for 10 days) who were subsequently randomized to receive normal diets of standard chow, sucrose loaded chow, glucose loaded chow or a high glucose fat diet with half of each group recieving 3% (-)-Hydroxycitric acid (85mmol/kg) and then followed for 10 days (so overall, 8 groups of which 4 had HCA supplementation). [23] This study noted that the inevitable weight regain in these rats was attenuated with HCA supplementation in all groups except normal chow, and only reached significance with glucose and glucose+fat diet groups; this was in part due to less food intake, and appeared to decrease the food efficiency ratio with all groups except standard chow. [23] This trial style was replicated with the glucose group, and it was noted that food intake was suppressed for a short time, and although there was indication that de novo lipogenesis may have been inhibited there was no significant suppressive effect on body weight regain. [24]

Two rat studies suggesting that Garcinia can reduce the amount of weight regained during a period of overfeeding after a period of low caloric intake

5.4. Weight Gain

A rat trial in which rats were fed an obesogenic diet for 15 days with 2% added (-)-Hydroxycitric acid (as trisodium conjugate) noted that the food efficiency ratio decreased to 60% of control, and that body weight gain was suppressed to approximately half (49%) of control; food intake also decreased 17%, which would have contributed to the observed reduction in weight. [25]

One rat study suggesting that Garcinia can attenuate the rate of weight gain

5.5. Weight Loss

A study in human subjects using 2g Garcinia cambogia (60% Hydroxycitric acid) for 10 weeks in 86 overweight adults failed to find significant differences in weight loss or food intake. [19] One study using 2400mg of Garcinia cambogia daily divided before meals noted that while active treatment lost more weight from a low calorie diet than placebo over a period of 12 weeks (3.7+/-3.1kg weight loss rather than 2.4+/-2.9kg) that there were no reported differences in appetite. [26]

One of the larger and better controlled studies on the matter noted that, 1000mg of Garcinia Camboga (50% HCA by weight) taken before the three main meals of a low calorie diet given to overweight but otherwise healthy adults (of which placebo was also placed on) and then followed for 12 weeks failed to find any significant differences in dropout rates, weight loss, or adverse effects relative to placebo. [27]

Studies done in humans using isolated Garcinia Cambogia have mixed results on fat loss, with the one study reporting benefit showing relatively low magnitude of benefit (1.3kg more than placebo over 3 months, with very high variability)

In 40 persons with a BMI between 27.5-39 (mostly obese) given 100mg Garcinia Cambogia (confounded with inclusion of 400mg Inulin and 200mg White Kidney bean extract) before each of the three major meals for a period of 12 weeks, with both placebo and supplemental group being advised to diet (1200kcal), noted that weight loss in the diet and supplement group was greater (4% body weight over 12 weeks) than the diet and placebo group (not statistically significance). [1] Dropouts from the study were also greater in placebo (6) than supplement (1) groups. [1] One other study that uses Garcinia Cambogia but is highly confounded with other nutrients also noted beneficial effects on weight loss. [3]

The studies that are associated with both weight loss and Garcinia Camboga are confounded with many ingredients, and the observed effects on fat loss cannot be attributed to Garcinia itself

Several reviews on the efficacy of Garcinia Cambogia suggest no significant benefit for weight loss in human interventions. [28] [29] [30] [31] [32] The rather frequent inclusion of Garcinia Cambogia in review articles relative to the lack of interventions may be related to the popularity of the supplement.

Numerous review articles assessing the evidence of Garcinia Cambogia conclude that there is no significant benefit of this compound in humans

6 Interactions with Glucose Metabolism

6.1. Glycogen

When 500mg (-)-Hydroxycitric acid is consumed alongside 2g/kg carbohydrate post exercise in humans, a slight increase in the rate of glycogen resynthesis occurs.

Everyone knows how frustrating it is trying to lose weight.

[33]

7 Interactions with Hormones

7.1. Testosterone

1667.3mg of Garcinia Cambogia for 12 weeks (1000mg (-)-Hydroxycitric acid) failed to find significant influences on serum testosterone. [34]

7.2. Estrogen

1667.3mg of Garcinia Cambogia for 12 weeks (1000mg (-)-Hydroxycitric acid) failed to find significant influences on serum estrogens (estrone and estradiol). [34]

8 Interactions with Organ Systems

8.1. Kidney and Bladder

While ingestion of a high-fat or high-sucrose diet is able to increase serum levels of urea and creatinine (thought to be indicative of kidney impairment), coingestion of Garcinia Cambogia at 50mg/kg is able to effectively normalize the increases in creatinine and urea. [35]

Oral ingestion of the leaves from Garcinia Cambogia at 100-200mg/kg of either the water extract or ethanolic extract was able to increase urine output in the range of 36-72% (ethanolic) or 17-39% (aqueous), both of which underperformed to 20mg/kg injections of the reference drug furosemide. [36]

The leaves of Garcinia may have weak diuretic properties

One study noted that oral consumption of 778-1244mg/kg bodyweight of (-)-Hydroxycitric acid to rats for up to 93 days was associated with testicular toxiciy with lower doses not associated with testicular toxicity. [37] This study has been critiqued, [38] where the lack of assurance on the salt form was questioned and the fact that the No Obervable Adverse Effect Limit (NOAEL) of 389mg/kg in rats is still 10-16 fold higher than the typical recommended serving for humans. [38]

A lone report on testicular toxicity with high dose (-)-Hydroxycitric acid consumption; may not be relevant to human supplementation doses

9 Safety and Toxicology

9.1. General

Acute (14 day) administration of 5000mg/kg bodyweight (-)-Hydroxycitric Acid to albino rats of both genders (small sample size of 10) was not associated with any mortality or clinical signs of toxicology. [15]

Studies that do not inhernetly design themselves to assess toxicology but nevertheless use (-)-Hydroxycitric acid supplementation have also failed to find any toxicity associated with 3% of the rat diet for 5 days [24] or 10 days, [23] or up to 5% of the feed for 90 days. [39]

Currently, the human trials cited in Examine do not report any adverse effects that occur in the treatment groups (using Garcinia Camboga) to a greater degree than placebo.

No observable toxicity in rats or humans following oral ingestion at this moment in time

9.2. Mutagenicity

A preliminary study assessing the mutagenicity of (-)-Hydroxycitric acid on five strains of Salmonella typhimurium (TA98, TA100, TA102, TA1535, and TA1537) up to 5000mcg/plate failed to find evidence of DNA damage or mutagenicity associated with (-)-Hydroxycitric Acid [40] and a lack of genotoxicity was repeatedly demonstrated elsewhere with the Ames test; [40] [41] this latter study noted that (-)-HCA increased the amount of micronucleated polychromatic erythrocytes (MNPCEs) after intravenous administration, which is though to be genotoxic. [41] The conclusion of this has been criticized for being suggestive of genotoxicity while the study had some design flaws (used DSMO alongside (-)-HCA while control got water, DMSO not being recommended for this test [42] ) and no LD50 test of the method of administration prior to genotoxicity testing. [43]

In rats given up to 5% (-)-Hydroxycitric acid in feed intake for a period of 90 days, there does not appear to be any significant DNA fragmentation in the liver or testicles. [17]

There does not appear to be any influence of the bioactive (-)-Hydroxycitric acid on DNA fragmentation or genomic damage; unlikely to be carcinogenic

9.3. Case Studies

There are numerous case reports of hepatoxicity associated with a supplement known as 'Hydroxycut' which touts Garcinia Cambogia as the main active ingredient, [44] [45] although it has been argued that there is no evidence to suggest a link to (-)-Hydroxycitric acid due to inclusion of many ingredients. [46]

In a patient on chronic Monteluskat treatment who then consumed two supplements, fatality occurred; it was thought that Montelukast interacted advesely with one of the many compounds consumed but causative could not be linked. [47]

One reported case of Rhabdoyolysis associated with a dietary supplement of which contained Garcinia Cambogia has been noted, although Ma Huang (plant source of ephedrine) is a large confound alongside chromium and Guarana. [48]

Due to the usage of Garcinia in fat burners, there has been reported connections between Garcinia and adverse effects; there is currently no evidence to assume a direct link between the compounds

Scientific Support & Reference Citations

References

  1. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin .
  2. Effects on the Human Body of a Dietary Supplement Containing L-Carnitine and Garcinia cambogia Extract: A Study using Double-blind Tests .
  3. Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial .
  4. Vasudeva N, Yadav N, Sharma SK. Natural products: a safest approach for obesity . Chin J Integr Med . (2012)
  5. Márquez F, et al. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans . Crit Rev Food Sci Nutr . (2012)
  6. Oluyemi KA, et al. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats . Biotechnol Appl Biochem . (2007)
  7. (−)-Hydroxycitric acid—the principal acid in the fruits of Garcinia cambogia desr .
  8. Masullo M, et al. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . (2008)
  9. Kolodziejczyk J, et al. Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma . Platelets . (2009)
  10. On the structures of garcinol, isogarcinol and camboginol .
  11. Chattopadhyay SK, Kumar S. Identification and quantification of two biologically active polyisoprenylated benzophenones xanthochymol and isoxanthochymol in Garcinia species using liquid chromatography-tandem mass spectrometry . J Chromatogr B Analyt Technol Biomed Life Sci . (2006)
  12. Chattopadhyay SK, Kumar S. Liquid chromatography-tandem mass spectrometry method for identification and quantification of two biologically active polyisoprenylated benzophenones, isoxanthochymol and camboginol, in Garcinia species . Biomed Chromatogr . (2007)
  13. Chattopadhyay SK, Kumar S. A rapid liquid chromatography-tandem mass spectrometry method for quantification of a biologically active molecule camboginol in the extract of Garcinia cambogia . Biomed Chromatogr . (2007)
  14. Loe YC, et al. Gas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentration . Anal Biochem . (2001)
  15. Ohia SE, et al. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX) . Mol Cell Biochem . (2002)
  16. Hayamizu K, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice . Fitoterapia . (2003)
  17. Shara M, et al.

    cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue.

    Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days . Mol Cell Biochem . (2003)

  18. Amin KA, Kamel HH, Abd Eltawab MA. The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid . Lipids Health Dis . (2011)
  19. Kim JE, et al. Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial . Nutr J . (2011)
  20. Watson JA, Lowenstein JM. Citrate and the conversion of carbohydrate into fat. Fatty acid synthesis by a combination of cytoplasm and mitochondria . J Biol Chem . (1970)
  21. Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo . J Biol Chem . (1971)
  22. Hellerstein MK. De novo lipogenesis in humans: metabolic and regulatory aspects . Eur J Clin Nutr . (1999)
  23. Leonhardt M, Hrupka B, Langhans W. Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats . Physiol Behav . (2001)
  24. Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding . Nutrition . (2004)
  25. Lipid-lowering and antiobesity effect of (−)hydroxycitric acid .
  26. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables . Physiol Behav . (2000)
  27. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial . JAMA . (1998)
  28. Egras AM, et al. An evidence-based review of fat modifying supplemental weight loss products . J Obes . (2011)
  29. Cherniack EP. Potential applications for alternative medicine to treat obesity in an aging population . Altern Med Rev . (2008)
  30. Lenz TL, Hamilton WR. Supplemental products used for weight loss . J Am Pharm Assoc (2003) . (2004)
  31. Pittler MH, Ernst E. Dietary supplements for body-weight reduction: a systematic review . Am J Clin Nutr . (2004)
  32. Heber D. Herbal preparations for obesity: are they useful . Prim Care . (2003)
  33. Cheng IS, et al. Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle . Br J Nutr . (2012)
  34. Hayamizu K, et al. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects . Fitoterapia . (2008)
  35. Amin KA, Kamel HH, Abd Eltawab MA. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet . Lipids Health Dis . (2011)
  36. Mathew GE, et al. Diuretic activity of leaves of garcinia cambogia in rats . Indian J Pharm Sci . (2011)
  37. Saito M, et al. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis . Food Chem Toxicol . (2005)
  38. Burdock G, et al. Garcinia cambogia toxicity is misleading . Food Chem Toxicol . (2005)
  39. Shara M, et al. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days . Mol Cell Biochem . (2004)
  40. Soni MG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt . Food Chem Toxicol . (2004)
  41. Lee KH, Lee BM. Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia . J Toxicol Environ Health A . (2007)
  42. Hayashi M, et al. In vivo rodent erythrocyte micronucleus assay . Mutat Res . (1994)
  43. Lau FC, Bagchi M, Bagchi D. Refuting "Evaluation of the genotoxitocity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia Cambogia" by Lee and Lee, Journal of Toxicology and Environmental Health, 70:388-392, 2007 . J Toxicol Environ Health A . (2008)
  44. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut . Ann Intern Med . (2005)
  45. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance . World J Gastroenterol . (2009)
  46. Stohs SJ, et al. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid . World J Gastroenterol . (2009)
  47. Actis GC, et al. Fatal liver failure following food supplements during chronic treatment with montelukast . Dig Liver Dis . (2007)
  48. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine . Am J Med Sci . (2004)

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Garcinia Cambogia Extract for Natural Weight Loss?

Garcinia 101: Review What is Garcinia Fruit’s Secret Truth?

Garcinia Cambogia Science, Studies & Medical Literature

100% All Natural Pure Garcinia Cambogia Ingredients

Garcinia Cambogia (mangosteen extract) is known as the “Queen of All Fruits” + considered one of the best tasting, rare + exotic nutrient-dense superfruits in the world – but now is being recognized for a different purpose: “The Holy Grail of Weight Loss?” – What’s the “Garcinia Truth“?

  • Faster Weight Loss by acting as a Fat Blocker
  • Natural Appetite Suppressant to control Hunger and Overeating
  • Increase Serotonin for Better Sleep and Regulating Moods
  • Balance Stress Hormones for Emotional Eaters & Manage Cortisol
  • Control Sugar Cravings Built by Marketers for Marketers

A complete review about Doctor Oz’s Garcinia Cambogia HCA Extract weight loss announcement and requirements necessary to meet the expectations and standards of garcinia supplementation and it’s powerful punch in the battle against the bulge.

  • Contains 50% Pure HCA (Hydroxycitric Acid) for Best Results
  • 500mg Pure Garcinia Cambogia Extract Minimum Dosage
  • Contains Calcium and Potassium to help with metabolism
  • Free from Artificial Fillers and Binders for Maximum Purity
  • All Natural Ingredients with no Side Effects & Maximum Potency
  • Free 7 Day Garcinia Cambogia Diet Action Plan Guide

Enter your email below to receive a Free Report on Pure Garcinia Cambogia Extract supplementation on whether or not Mangosteen’s Hydroxycitric Acid extract (derived from the juicy white pulp/flesh in the center of the thick reddish-purple pericarp rind) really works as a viable option to lose weight and suppress appetite as it has been proclaimed to do so?

This carefully-crafted, beautifully-developed 17-page Garcinia Cambogia Extract Weight Loss comprehensive overview provides the raw knowledge required to make an educated, informed decision right away.

The focus and intention is to give an all-encompassing guide on real clinical data and medical literature facts supporting the legitimacy of garcinia cambogia’s benefits, side effects and health claims.

Knowing many individuals are looking for a quicker, natural alternative method to burn fat more effectively and efficiently, this revealing natural weight loss guide is meant to help answer the question “is this supplement right for you?”

To show you exactly what we found out regarding the Garcinia Cambogia Weight Loss Truth, and whether or not we think you should try the liquid or pill form supplements for the best effects and results.

What Exactly is Garcinia Cambogia Extract?

Traditionally in many countries around the world, primarily Southeast Asia, pure Garcinia extracts have been used to concoct juices, teas, and topical healing ointments because of its antioxidant-rich xanthones (discussed below) properties.

The chief aim and purpose is to reveal the science, results, and truth regarding how healthy Garcinia superfruit can be to take on a regular basis.

Do you find yourself craving some type of food even after you’ve already eaten a large meal?

People who live in the region have long used this incredible tiny fruit to make dishes more filling.

Do you find yourself snacking on high calorie foods that have very little nutritional value?

For those that don’t watch much T.V, a recent airing of the Dr. Oz television show featured the amazing weight loss benefits of an exotic fruit known as Garcinia Cambogia.

With all of the proven weight loss results that its clinical trial participants have experienced, Garcinia Cambogia quickly became the next big thing in weight loss supplements. But is it legit?

Health Benefits of Pure Garcinia Cambogia Extract

  • Increases Serotonin Levels to Enhance Mood and Relieve Stress
  • Uses Serotonin to Help the Body Get More Quality Sleep
  • Naturally Suppresses the Appetite Using HCA
  • Blocks the Production of Fat
  • Helps Reduce Cravings for Carbohydrates, Sugars, and Junk Food
  • Increases Weight Loss Efforts

As busy Americans that are usually short on time when it comes to meal time, it’s no wonder why there are so many fast food restaurants popping up on every corner in the city.

But even if you’re not a fan of eating out at fast food restaurants, the food that you buy from the grocery store may be just as unhealthy as fast food.

The sad fact is that many people who are short on time usually don’t want to be bothered with long meal preparation time and doing the dishes so their solution to meal time is to purchase fast food, boxed meals, frozen dinners, microwaveable food, and junk food.

However, all of your weight problems can become a distant memory just by consuming the extract of a fruit known as Garcinia Cambogia.

This exotic fruit is a small plum-colored super fruit that is primarily grown in tropical regions such as Asia.

Recent discoveries found that the rinds of the Garcinia Cambogia fruit are one of the few fruits in the world that contain extremely high levels of Hydroxycitric Acid (HCA).

This particular type of acid is known for its ability to suppress the appetite, reduce cravings for sugars and carbohydrates, and block the fat intake from any consumed foods.

Garcinia Cambogia also provides many other health benefits such as preventing the buildup of bad cholesterol, reducing the amount of triglycerides in the body, and increasing the level of serotonin in the brain.

Serotonin is the primary element in the brain that is responsible for feelings and moods.

If the brain doesn’t have enough serotonin to balance out your emotions, you are more susceptible to experiencing high levels of sadness and severe depression.

When this happens, the feelings of overwhelming sadness and depression will usually lead to emotional eating.

This is where Garcinia Cambogia can step in to give your body the willpower it needs to resist cravings and prevent you from wanting to eat an entire tub of ice cream.

Does Garcinia Cambogia Work?

Although Garcinia Cambogia has been hailed a miracle weight loss supplement by Dr. Oz and Dr. Julie Chen, this does not mean that you should take their word for it.

Just take a look at the several clinical studies that have been conducted to research the natural health benefits of Garcinia Cambogia and you will see that this fruit has proven that it can do exactly what it says it can do.

The two main functions of Garcinia Cambogia are to prevent fat cells from forming by preventing the liver from converting sugars into fat, and to suppress the appetite by increasing serotonin levels to give you more control over your emotional eating habits.

This can give you a better edge on saying “no” to junk food, sugary food, and carbohydrates so that you can be well on your way to a slimmer waist and much happier days!

Choosing Best Garcinia Cambogia Supplement

The Garcinia Cambogia Review above has provided an analysis and outline on what garcinia superfruit is and also on whether or not it works.

The key question comes down to how to choose the best quality version of Garcinia and whether or not you should try a liquid based supplement versus a pill/powder form.

To see our complete breakdown of liquid vs pill garcinia cambogia supplementation click the button, otherwise click the button below to get our preferred choice for optimal results and benefits.

November 2015 Garcinia Cambogia Extract Update

From now on, all future garcinia cambogia updates will take place at http://supplementpolice.com/garcinia-cambogia due to their relentless research, scientific insight, and uncanny ability to connect the dots for health debates and discussions involving dietary supplementation use of garcinia related supplements.

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