Garcinia plus benefits

Garcinia plus benefits
Apparently, she lost as much as 35lbs in just less than one month to reveal her ever-perfect figure on Instagram.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

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Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G.

Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M.

cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA .

The product must have at least 50% pure and potent garcinia cambogia extract.3.

They lead the pack because they're made with 100% ALL-NATURAL ingredients, made with 60% Pure HCA, produced in FDA-registered laboratories that adhere to the standards set by FDA's Good Manufacturing Practices.

1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.

45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem . 2003;254(1-2):339-346.

47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.

48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.

49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

Copyright © 2009 Wolters Kluwer Health

Garcinia Cambogia: Does This Hyped Weight Loss Supplement Really Work?

Garcinia cambogia (GC) is a small, pumpkin-shaped fruit that grows in Southeast Asia and India. The key active ingredient found in the rind of garcinia cambogia is hydroxycitric acid (HCA), which some research suggests can help certain people lose weight. (1)

Currently, there are at least 14 separate HCA-containing products sold over-the-counter to consumers labeled as “garcinia cambogia.” Most people are drawn to the idea of using GC because of the potential that it can provide near-effortless, quick weight loss without the need to change someone’s overall diet or lifestyle very much.

GC itself is not a new product; in fact, it’s been consumed in parts of Asia for many years, although not for the purpose of losing weight. Since GC (traditionally also known as the Malabar tamarind) first began to gain popularity in the U.S. several years ago — after appearing frequently in the media and on popular health-related TV shows — sales have gone up dramatically. More and more people are purchasing this so-called “weight loss miracle drug” in hopes of losing stubborn body and stomach fat they’ve been struggling with for years.

But just like most other weight-loss supplements, pills and products, studies regarding GC’s effects and safety have been mixed. While there’s some evidence that HCA might be able to aid in weight loss even when someone does not exercise often or change his or her diet very much, there’s also concerns regarding serious side effects that can occur, including liver damage or failure, anxiety, fatigue, dizziness, and digestive problems.

Remember that just because GC is derived from a natural fruit doesn’t mean it’s always completely safe. So is garcinia cambogia ultimately worth trying? What’s the truth with this purported weight-loss supplement? Let’s take a look at how HCA works, in what situations GC might be helpful, and what adverse reactions are possible when using any type of weight loss drug.

Finally, it’s worth considering the fact that time and time again we see various fad diets and products publicized to help boost weight loss — but what really works in the end is living a healthy lifestyle long term.

Does Garcinia Cambogia Work? What the Studies Tell Us

Garcinia cambogia reviews, research results and weight loss testimonials have been mixed to say the least. By far the most well-publicized benefit of using garcinia cambogia is its ability to increase weight loss. Other claims that are commonly made about garcinia cambogia’s effects include:

  • loss of appetite or less of a desire to eat than usual
  • reduced cravings for unhealthy foods, such as sugar addiction
  • a more positive mood (including feeling happier, more energetic and less tired)
  • increased energy and concentration
  • stabilized blood sugar levels
  • improved bowel movements
  • reduced joint pains
  • improved cholesterol levels
  • stronger desire to be physically active

Most of the claims above have not been backed by scientific studies, however some have. Let’s review the benefits of garcinia cambogia that actually have some merit and seem to be effective in some manner.

Some studies have found that garcinia cambogia might, in fact, be able to help with low amounts of fat loss, plus some of the other health concerns mentioned above, although its effectiveness is rarely strong or consistent. For example, research suggests that HCA works by blocking a certain enzyme called adenosine triphosphate-citrate-lyase, which contributes to the formation of fat cells. But studies comparing GC’s effects to controls have found that it might only increase weight loss by a mere one to two pounds on average.

These findings are exactly what researchers published in the Journal of Obesity in 2011. When they compared people who took garcinia cambogia extract to those who didn’t, the weight difference was very small (on average just about two pounds). Plus, it wasn’t even possible to conclude that GC was directly responsible for the additional pounds lost.

The meta-analysis reviewed results from 12 different trails involving GC and revealed a small, statistically significant difference in weight loss favoring use of garcinia cambogia products containing HCA slightly over use of a placebo. However, the analysis also found that some studies showed digestive side effects (“gastrointestinal adverse events”) were twice as common in HCA groups compared with placebo.

Results from various weight loss studies involving GC have been very mixed.

In fact, since the FDA does not regulate most supplements on the market, some garcinia Cambogia supplements have shown to be ineffective and dangerous.

One study in the meta-analysis reported a significant decrease in fat mass in the HCA group compared with placebo, two studies reported a significant decrease in visceral fat/subcutaneous fat/total fat areas in the HCA group compared with placebo, but two other studies found no significant difference at all between HCA and placebo. A study that was published in the Journal of the American Medical Association found that GC used for 12 weeks (1,500 milligrams dosage) “failed to produce significant weight loss and fat mass loss beyond that observed with placebo.” (2)

The conclusion of the meta-analysis regarding garcinia cambogia? Researchers summed up their findings by saying that “the magnitude of the effects are small, and the clinical relevance is uncertain. Future trials should be more rigorous and better reported.” (3) The bottom line is that if you’re struggling to lose weight, GC likely won’t be the answer, according to trial and controlled studies.

Studies have also suggested that it’s possible that HCA found in garcinia cambogia can help lower someone’s appetite by increasing production of the neurotransmitter serotonin, which is associated with calm and happy feelings — and therefore, sometimes appetite suppression, less cravings and reduced desire for comfort foods. Animal studies show it might also help increase energy expenditure. (4)

Keep in mind, however, that this isn’t the case with all people, and there are other, potentially less risky ways to better manage your appetite and boost serotonin production (such as eating balanced meals with protein foods and healthy carbs at regular times throughout the day).

There’s some support for garcinia cambogia being able to improve cholesterol levels and lower high triglycerides. It might also be able to help raise HDL “good” cholesterol. It’s not safe for anyone already taking medications that affect cholesterol, however, and its effects don’t seem to be very reliable or strong.

Studies have found that GC has “no significant effect on anthropometric parameters, REE, triglycerides or glucose levels” but might have a small effect on lowering cholesterol. (5) Keep in mind that there are also plenty of other natural ways to improve cholesterol levels, including exercising and eating more dietary fiber from high-fiber foods like veggies, nuts, seeds and beans.

Finally, what about CG’s effects on blood sugar levels? Some evidence exists showing that garcinia cambogia can help control blood sugar by improving how cells take up glucose (sugar) to be used for energy. One way in which it might improve weight loss is through inhibition of pancreatic alpha amylase enzymes, changes in intestinal alpha glucosidase and alterations in fatty acid synthesis. This might be able to change how carbohydrates are metabolized. (6)

This might possibly help your body respond to insulin better, although it can raise the risk for having low blood sugar levels in some people, too. If you have a history of blood sugar swings, you’re prediabetic, diabetic or taking medications that alter insulin’s effects, GC might make your blood sugar drop dangerously low. While this doesn’t appear to happen in everyone who takes GC, it’s something else to consider and something to discuss with your doctor.

Potential Garcinia Cambogia Side Effects

While some people claim they don’t experience any side effects at all from using GC, others have had very different experiences. Here’s one disturbing account regarding the use of garcinia cambogia extract that you might not have heard about: It’s contributed to at least several patients winding up in the hospital with liver failure and needing emergency liver transplants.

A 2016 article published by the Transplantation Center at the Mayo Clinic reports that millions of Americans regularly use herbal supplements, often in pill form, but aren’t aware of their full effects. Many weight loss drugs pose potential hidden dangers and are “associated with hepatotoxicity and acute liver injury.” (7)

In the case of garcinia cambogia, it can easily be overused and is not very well-regulated. Some manufacturers recommend taking high doses multiple times per day, for example 30 to 60 minutes before every meal for eight to 12 weeks straight. (8) Aside from liver damage, other garcinia cambogia side effects that can occur include:

  • becoming fuzzy or weak
  • fatigue and brain fog
  • skin rashes
  • an increase in catching colds/lower immune function
  • dry mouth and bad breath
  • headaches
  • digestive issues like nausea, trouble eating or diarrhea

Something else to consider about GC is the long list of its potential medical/drug interactions. Many people should avoid garcinia cambogia due to how it can affect other medications, pregnancy, nutrient levels, blood sugar and more. Garcinia cambogia can potentially interact badly with: (9)

  • pregnancy and breastfeeding
  • existing cases of liver or kidney damage
  • medications that are taken to control asthma and allergies
  • diabetes medications and insulin
  • iron supplements (usually taken by people with anemia)
  • pain medications
  • medications used to control mental disorders like anxiety and depression
  • statin drugs that lower cholesterol
  • blood thinning drugs (like warfarin)

How Much Garcinia Cambogia Should You Take?

If you decide that you still want to try taking GC for weight loss or its other benefits, here’s what you need to know about dosage recommendations for products containing HCA:

  • Studies using GC have used a wide range of doses, anywhere from one gram to 2.8 grams daily. Typical doses are ususally between 250–1,000 milligrams per day.
  • Study durations have also varied widely, ranging from using GC between two to 12 weeks at a time.
  • The optimal dose of HCA is currently still unknown. It’s not clear if a higher HCA dosage even means a higher bioavailability of HCA once consumed.
  • There does seem to be a significant correlation between the dosage of HCA and body weight loss, meaning higher doses have slightly more effects.
  • Garcinia cambogia continues to be the most widely used supplement in studies for providing HCA, however aside from GC, HCA can also be found in supplements made from the plant Hibiscus subdariffa.
  • Because most studies have investigated the effects of GC taken for about eight weeks, researchers believe this is ultimately “too short a time to assess the effects of HCA on body weight.”

To err on the safe side, avoid buying garcinia cambogia “formulas” or “supplement blends,” which might fail to report all of the other ingredients included or accurate levels of HCA. Many proprietary formulas are made by manufacturers that only use a fraction of the active ingredient or standard dose to keep costs down. Always read labels and look for the words “pure garcinia cambogia” and “hydroxycitric acid (or HCA) extract” (this should be around 50 percent to 60 percent of the product). If you purchase a blend and see an ingredient listed without an amount, that can be a red flag that you don’t know exactly what you’re getting.

11 Weight Loss Methods That Really Do Work

In just about all studies involving garcinia cambogia, researchers note that it’s hard to tell if any demonstrated benefits (weight loss, reduced cholesterol, etc.) are really due to GC or are actually influenced by other factors like the subjects eating lower-calorie diets or exercising. It’s always possible for any supplement to cause a “placebo effect,” where subjects wind up changing their outlook and habits simply because they believe the product is helping them (even if it isn’t actually doing anything).

Another interesting fact that the Journal of Obesity meta-analsis reports is that most of the included studies “failed to indicate whether or not outcome assessors were blinded, and seven studies did not even specify who funded the garcinia cambogia studies.” While it’s possible that garcinia cambogia might help you lose an additional one to two pounds if you take it regularly, most experts don’t think it’s worth the money or the risk — especially considering its effects are so small and inconsistent.

Ultimately, taking weight loss supplements won’t teach you much about eating an overall healthy diet, finding ways to enjoy exercise, or practicing “intuitive eating” and managing cravings. So what can you do to move in the right direction of losing weight safely? Weight loss efforts should always be realistic, safe and sustainable. Remember that the real goal is to reach a healthy weight and stay there for life. That’s why quick fixes and fad diets have been shown in studies to fail in the long run over 95 percent of the time.

Here are some of my favorite tips for losing weight using reliable methods that really work:

  1. Get good sleep! A lack of sleep (less than seven to nine hours nightly for most people) can mean a lack of weight loss.
  2. Eat more fiber: Adults need to aim for at least 25–30 grams daily from things like veggies, fruit, ancient grains, sprouted legumes and seeds.
  3. Use healthy fats: Coconut oil has natural fat-burning effects just like GC does, plus many more benefits like improving gut health, too.

    The weight loss studies on Garcinia cambogia that have been performed on humans have been mostly inconclusive or have shown no significant weight loss results.

    Other healthy fats that can help control your appetite include real olive oil, avocado, fats from grass-fed beef, nuts and seeds.

  4. Utilize adaptogen herbs: Adaptogen herbs like maca, ginseng and rhodiola can help control health conditions that can make it hard to lose weight (like high amounts of stress, thyroid issues, leaky gut, adrenal fatigue, cellular toxicity and candida).
  5. Don’t skimp on protein: Protein foods are satisfying and essential for building muscles. Regularly include proteins like cage-free eggs and wild-caught fish in your meals.
  6. Consume probiotics: Probiotic foods and supplements not only help balance improve digestive health, but they also balance hormones, raise immunity, control your appetite and play a part in weight control.
  7. Switch up your exercise routine: Try burst-training exercises and other forms of high intensity interval training (HIIT) to keep challenging your muscles, work in with a group, add in weight training, and relax with yoga in between workouts.
  8. Stand up more during the day: Sitting for long periods of time is associated with being overweight and a higher risk for obesity.
  9. Sneak more fitness into your day: Take the stairs, do body weight exercises at home. or try wearing a fitness tracker for motivation — try some of these exercise hacks.
  10. Schedule your workouts ahead of time: This makes it much more likely you’ll follow through.
  11. Useessential oils for weight loss: Natural oils including grapefruit, cinnamon and ginger oil can help control your appetite, hormones and digestive symptoms.

From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.

Garcinia Cambogia Free Trial – Dr Oz Garcinia Cambogia

Superfoods are definitely a dime a dozen nowadays. With science working really hard to find new ways to solve obesity and make people healthier, natural food items are becoming all the rage once researchers determine that they have special components that can help people lose weight. It’s definitely a great thing, as more options are becoming easily available to the public.

This is why our dr oz garcinia cambogia free trial comes in. Introducing the latest superfood that will help you shed some pounds safely and effectively, this new product features the garcinia cambogia, also known as the Malabar tamarind. A close cousin to another famous superfood, the mangosteen, it shows great promise in being one of the best ingredients for weight loss supplements.

What is Garcinia Cambogia?

If you’ve been updated with the latest health trends, you might have already heard about garcinia cambogia from fellow health buffs and weight loss enthusiasts. It has been around for a few years already and a lot of people have already been taking advantage of what it can offer for quite a while now.

First off, it is a tropical fruit that is native to India, Indonesia, Sri Lanka, Malaysia, and Myanmar. Being closely related to mangosteen, you can expect them to look a lot alike. In fact, they do have similar appearances, but the Malabar tamarind gets a red or yellowish color when it ripens, making it look a lot like a pumpkin once it is ready for consumption. It can grow to a size of a grapefruit, has a brownish pulp and a strong sour taste, which is just common in most members of the tamarind family.

The Malabar tamarind has been widely consumed in its native homes as well. People dry the rinds and add them to chutneys and curries, adding a distinctive tang to meats and other dishes. Some also use it to flavor drinks.

What some people didn’t know, though, is that the garcinia cambogia has always been used as a home remedy by people who have easy access to it. They’ve been using it to calm upset tummies for centuries, aiding conditions that include constipation, diarrhea, and ulcers. Being a fruit that is rich in nutrients, it also offers more health benefits to those who wish to consume it.

Famous docotr dr.oz Introduced first on TV and recommended.While the garcinia cambogia dr oz is best known for having weight loss properties though, they also have other ingredients that can help boost your health. Some of the most notable ones include:

Xanthones are plant polyphenols that are known to be effective in fighting cancer. These nutrients are said to support programmed cell death so cancer cells won’t spread further. They also have anti-inflammatory properties, keeping the body in good shape.

Garcinols are the kind of benzophenone present in garcinia cambogia. They act as antioxidants that can lessen the inflammation in the body. They also have antibacterial effects preventing infections from spreading and getting worse.

Hydroxycitric acid or HCA:

HCA is the primary reason why garcinia cambogia is rising to fame as of late. This ingredient can stop a particular enzyme called the citrate lyase from turning sugar to fat. It then makes it easier for the body to make use of glucose and turn it into energy, resulting to lower insulin levels and weight loss.

How Does Garcinia Cambogia Extract Help You Lose Weight?

It might sound overly simplistic that a simple natural ingredient can help you lose weight, but it’s actually true. Garcinia Cambogia Extract’s HCA content could help you shed some pounds. Everyone who’s trying to lose weight will know that the body likes to store fat in case of emergency. With a generous fat storage, the body ensures its safety, knowing that it has a sizeable amount of reserve should it need additional nutrients and energy in the future.

By having a sedentary lifestyle or some hormonal issues, the body will work harder to store more fats. This is why a lot of experts push for more physical activities, as burning fats can be quite challenging.

HCA became all the rage because it gave people a good way to manage their weight without having to workout so hard. With HCA, you can trick the body to skip the fat storage part and skip to using the sugar you’ve ingested right away.

Aside from this, garcinia cambogia’s HCA levels also work as an effective appetite suppressant. Unlike other superfoods, though, it works by upping your satisfaction from the food you intake. This means that you’re not only satiated with a small meal, but you actually get easy satisfaction from what you eat. This makes it a lot easier to eat less, helping you minimize the calories you have to burn and be able to work on expensing stored fats right away.

Garcinia cambogia is also said to contain ingredients that can boost your production of the hormone known as serotonin. This hormone helps balance out mood swings, so it makes you less emotional and can actually make you feel happier. It benefits those who like to stress eat, as they won’t feel the need to gorge on fatty and greasy comfort food every time they get upset or stressed out.

Other Benefits of Garcinia Cambogia

Aside from weight loss, garcinia cambogia extract has a wide array of other benefits, making many consider it to be the holy grail of weight loss nowadays. This makes this superfood even more attractive for many, as not only will they be able to shed some pounds, but they can also be healthier in the process.

Other benefits of the Malabar tamarind include:

Some studies have shown that pure garcinia cambogia extraxt is able to lower your body’s triglycerides levels and LDL, also known as the “bad” cholesterol and raise HDL levels, referred by many as the “good” cholesterol. This is a good thing as a lot of people who want to lose weight may also be struggling with high cholesterol levels. It comes with the territory, really, especially if you love to binge eat fatty foods. With this superfood, you can be rest assured that you’re covering all of your bases as you try to lose weight.

Another reason why garcinia cambogia has gained much popularity as of late is the fact that it can lower insulin levels. The HCA in this superfood inhibits the liver from processing the sugar. This results to the prevention of creation of new fat cells from what you’ve just eaten. The sugar will then be made easily available to convert to energy, letting you expend them easily and prevent piling up the pounds.

By making use of the sugar you ingest, the body also lowers its levels significantly. The main reason why those with diabetes have high sugar levels is because of their body’s inability to efficiently burn and consume the sugar they intake. With the help of the garcinia cambogia, you can quickly utilize the sugar you’ve eaten, preventing its storage and piling up in your body. So, not only do you get to lose weight with just consuming this superfood, but you also help your body stay energetic and well balanced.

This is one of the reasons why this superfood attractive to those who have diabetes. As a natural supplement feels safer to take than medications made from various compounds and chemicals, many gravitate towards controlling their ailment with a natural ingredient rather than a number of synthetic ones.

Higher red blood cell count:

Garcinia cambogia also contains a good amount of iron, which contributes to this superfood’s ability to increase the body’s production or red blood cells.

PRODUCT IS BOGUS ANYWAY I recently ordered the product.

While excessively high RBC count is considered as an ailment, elevating it just a smidge is still safe. Increasing it a bit more is even beneficial for those who want to improve their athletic performance further.

Since red blood cells contain oxygen, more red blood cells means more oxygen delivered to working muscles. This energizes the muscles and fuels them further. This, in turn, can help them train or workout longer and perform higher intensity routines even better. With the garcinia cambogia’s ability to raise red blood cell count to a higher, yet still safe, level, it is slowly becoming a popular health supplement for bodybuilders and strength athletes.

This superfood has been long used to treat stomach ailments by societies and communities that have always had access to the plant and fruit. This is why it doesn’t come as a surprise that it can also help manage ulcers and other stomach issues. According to a study done on rats with gastrointestinal ulcers, treatments with the use of garcinia cambogia has shown significant decrease on the subjects’ gastric juice levels and acidity.

So if you tend to have a sensitive stomach due to ulcers or hyperacidity, taking this superfood or its supplements will be safe for you. Some diet pills can actually make certain gastrointestinal issues worse, so if you already have the condition and are looking for safer alternatives for your weight loss, pure garcinia cambogia can be a good choice for you.

Safe to use in connection with other supplements:

While most natural supplements are safe to use, not all can be combined with other medications and supplements. Some may have a counter reaction with certain ingredients, making them pose risks to your wellbeing. Luckily, the Malabar tamarind isn’t one of them as these superfoods are perfectly okay to use with other supplements.

In fact, finding the right combination may even boost this superfood’s effectiveness. Taking a supplement with additional caffeine can help you burn fat even while you’re in a stationary position, letting you lose more weight as a result.

Combining it with a colon cleanser is also a good way to boost your weight loss measures. By clearing your colon, the garcinia cambogia can do its magic more efficiently, letting you gain more benefits out of all of your efforts.

Available in supplement form:

The fact that you can now enjoy Malabar tamarind extract in the form of Garcinia Cambogia Plus supplement is also a great plus. Since the tropical fruit can be a bit difficult to obtain in the US and other western countries, the fruit extract is the next best thing that you can take advantage of.

The supplement can even be more preferable than the actual fruit in most cases. For one, supplements will be much more affordable than having to acquire a rare tropical fruit from the other side of the planet. Of course there’s also the Garcinia Cambogia pure extract plus free trial that is easily available to you, so you don’t have to shell out on your first order of these wonderful diet supplements.

Then there’s also the fact that a supplement is a lot easier to intake. Especially if you’re not a huge fan of citrusy fruits, the Malabar tamarind can be hard to enjoy. With a free trial and succeeding orders of this product, you can skip all that and get to the most important contents of the fruit right away.

Not a lot of other superfood and their supplements can promise the same things as the Malabar tamarind can, which is probably why even popular health experts vouch for its effectiveness. There’s so many wonderful things that you can actually get from this superfood, so it totally makes sense to take advantage of it as you try to lose some weight.

Are There Any Garcinia Cambogia Side Effects?

Before you go ahead and sign up for the free trial bottle, you might want to know whether there are any side effects these extracts can have.well know and reputed Doctor in the health and medical community Dr OZ recommended garcinia cambogia as a one of the safest supplyment,While this product is perfectly safe, there are still a few things you need to keep in mind, like in any other natural supplement that you wish to intake. Some of these are the following:

Since the HCA of this superfood can lower sugar levels, it could aggravate the effects of diabetes treatments and medications. It’s best to check with your doctor first if you want to combine the two so your physician can provide the right dosage for your medications and ensure your safety.

As this supplement also contains iron, it might have a side effect to those who are taking meds for their anemia. Please consult with your doctor before taking garcinia cambogia supplements with such medications to prevent any possible complication.

  1. Potential adverse interaction with pain medications and prescription drugs for psychiatric conditions:

Like a lot of other supplements, those who are taking pain and psychiatric medications should take extra caution before trying this supplement. The prescription drugs that you’re taking can be too strong and are usually not designed to be taken with other natural meds, so see your doctor first before signing up for a free sample bottle.

Note that a lot of the possible Garcinia Cambogia Plus side effects might only apply to those who are taking heavy medications, similar to other natural supplements. If you have a pre-existing serious condition and you wish to shed some pounds with the help of this superfood, it’s best to seek your physician’s advice first. Your meds could be too strong to be combined with others, so it’s important to take precautionary measures in such cases.

Pure Garcinia Cambogia Extract Plus:

Made from a generous concentration of garcinia cambogia extract is one of the best sources of HCA in the market today. This natural diet supplement promises to wield the many benefits of the Malabar tamarind to help you lose weight safely and effectively, making shedding off the pounds a lot simpler and less frustrating.

With the Malabar tamarind being considered as a holy grail in weight loss as of late, it’s common to find supplements that can be dubious in their claims. Experts have discovered that a lot of products that promise to supply the body with ample amounts of garcinia cambogia actually contain less than what they advertise.

With this pure garcinia cambogia you can be sure that you’ll get the right amount of this superfood so you can enjoy its benefits and be on your way to losing weight. The best part here is that you can give it an initial go with our special trial offer without any risks.

As not all Malabar tamarind extract supplements are created the same, Garcinia Cambogia Plus wants to guarantee that what we have to offer is the best product in the market today. This is why the makers can stand proud and confident offering a free trial to consumers because of the certainty that people will discover just how great this particular supplement is and how beneficial it can be to your weight loss efforts.

Giving out trial bottle to those who want to try losing weight safely, quickly, and effectively is a win-win situation, really. If you’re one of those who are starting to get frustrated with having to try a lot of supplements just so you can weed out the ones that don’t work, you’ll easily find a good solution with this product. Since you can get it for free as an offer, you don’t have to get frustrated about paying for another product that you’re not certain about. And because this product will turn out to be effective, you’ll be overjoyed to find a great product that you know that you can trust. With less risks and investment, you won’t have to worry about giving a try.

Just think about it: with the free Garcinia Cambogia trial, you can easily get to know a quality product that will help you lose weight without you having to invest a lot of money to get started. It’s simple and promising, so why not give it a go?

How to Get Your Free Trial Offer :

Getting started on your free trial is easy. All you need to do is to follow a link provided for this very purpose and you’ll be redirected to a landing page where you’ll need to enter your delivery details. Fill out the form to let us know where to send your free bottle and wait until your supplements arrive. Take the pills twice a day and wait for the pounds to start going away.

If you want to accelerate the pace of your weight loss, you can easily combine your intake of this supplement with a healthy and balanced diet and exercise. As garcinia cambogia has properties that will boost your energy, you can find yourself able to handle high intensity workouts like never before and boosting your chances of getting a slimmer and healthier body.

Of course, if you’re not too keen on working out, you can also just sit back, relax, and wait for the garcinia cambogia free sample to do its magic. A lot of people do this and still experience astounding results, making these supplements even more desirable to those who wish to lose weight without the hard work.

Just remember to take the supplements twice a day, thirty to sixty minutes before meals to get the best results out of its ingredients. Make sure to take it only on an empty stomach as HCA needs some space to work its magic.

According to experts, if you take it with food in your system, it might bind with the food and be inactivated, so avoid doing such at all costs.