Pure garcinia cambogia canada stores

Pure garcinia cambogia canada stores
It is recommended that users follow a strict diet and exercise regimen to achieve weight loss results.

Alex Soft Releases Garcinia Cambogia Games

megadrox this is caption

From Flab to Fab With Weight Loss Pills

Who doesn’t want to look fab? You’d be able to wear whatever you want and still look damn fabulous. It is not that easy, though, unless you are skinny and fit, which happens to be just a small fraction of the population these days. Obesity is a growing concern and it is not just a medical issue but a psychological problem too as it brings with it various concerns on self-image, insecurity, and even self-harm. A body full of flab isn’t attractive. If you are using weight loss pills- be sure to study what it is inside them. Let us all acknowledge the obvious. However, we should not demean another person because of the way they look because not all the time it is of their own doing.

Being fat may be the result of poor lifestyle choices or utter laziness. The majority live a sedentary lifestyle and rarely go out anymore to exercise. We are so obsessed with tech gadgets that all we do all day is to lie down in bed and tinker with our smart gadgets or sit down on the couch and watch TV all day when we have nothing better to do. It slows down our metabolism and makes us more prone to gaining weight and staying fat. Even though we know this, we still don’t do something about it despite it being the cause of obesity that many of you are all complaining about. Being fat may also be a medical issue such as hormones running wild, which you have little control over and needs medical intervention.

Diet pills are a great way to get this off to a great start for yourself.

You don’t get fat overnight. Sure, you gain a pound or two and feel that your body suddenly expanded a little but it won’t leave a permanent damage. You get fat because of unhealthy habits that cause you to stay bloated forever, unless you do something about it. Regularly eating fastfood, junks, processed foods, sugary beverages and soda daily among others are just a few of the reasons you get fat and stay fat. It takes an iron will to resist temptation and resist your cravings. It is not an easy feat, which is why many people give up early on and just accept their fate of being overweight and obese than just constantly see their efforts go down the drain and start from scratch over and over again.

Most fitness supplements are great for this purpose.

What they fail to realize is that getting fit and weight loss can’t be achieved in a day or two, similar to how you don’t easily put on weight after just one eating binge. It is making those same mistakes over and over again just like procrastinators do. If you want to shed all your excess fats and start sporting a slimmer and healthier figure, you need to be up for the challenge and commit yourself to weight loss no matter what the odds are. The first obstacles you will likely face is your own self-doubt. You will doubt the efforts you are putting in and your own capability to commit to your goals. But once you do believe in yourself, know that nothing is impossible and you can achieve whatever you have set your mind and heart into.

Weight loss pills can be used for many different things.

http://thetopweightlosspills.com.au is a great place to tons of diet supplement reviews and info on related topics.

There are weight loss success stories you’d come across social media from time to time. The common denominator among them is that they usually had to make the ultimate decision of losing weight in the face of a life or health crisis. They usually decide to take charge of their lives again and looking fab from flabby is just a bonus. You have to commit to daily exercise routines. You don’t just exercise today and skip tomorrow because you just do not feel like it. Discipline is the key. You need to force yourself to commit to your goals regardless of how you feel that day. Put your emotions aside and visualize yourself 10, 20, 30, 40, 50, 60 pounds lighter. Imagine how lighter and healthier you will feel in your ideal weight. That should be inspiration enough.

A lot of diet pills simply are too expensive for the average person to afford.

Remember that it is not all about physical appearance. Some try to lose weight because of health reasons. Overweight and obese individuals are at higher risk f developing chronic, deadly and debilitating conditions like heart disease, stroke, diabetes, and many others. You don’t want to shorten your lifespan just because you are too lazy to move around and eat right. Don’t forget that while exercise is a big factor when it comes to weight loss, the food and amount of food you eat weighs just as much. After all, you are what you eat and it’s not just a cliché but a sad reality of life.

If you try to live healthy, you’ll soon notice that your appearance improves. So, let that be your focus. Do not obsess over weight loss because you’ll just get frustrated that you are not seeing the results you wanted fast enough. Invest in healthy habits because that will not only help you lose weight but even save your life. Try to transform your life by changing your life perspectives and behavior. If you adopt healthy eating habits and an active lifestyle, it will become second nature to you and you won’t have to exert that much effort the next time around. Little by little, you gradually stray away from your bad habits and are taking baby steps to the best version you can ever be. You’ll soon realize that you look and feel differently sooner rather than later. The importance of supplements and pills is increasingly becoming a priority all over the world. And the best thing about getting fit, you not only achieve your goals of dropping the excess pounds but turn your life around too. It’s all about being healthy. When you are healthy, you look and feel healthy. You may still be several pounds off the weighing scale but it won’t bother you nor mess with your confidence or self-image because you know better now.

Comparing Green Coffee Bean Extract With Garcinia Cambogia

If you look around you now, it is common to see overweight and obese people. In fact, their population is growing by the months and years that pass by. And it is not surprising at all considering how much fast food many of us eat on a daily basis. These people have proven, without a doubt, that you are what you eat. So, what do they usually do once they get wind of the problem? They go crash diet. Well, it works for a while but you do not really see long-term results, nor is it a solution in the first place. You only mess up with your digestion consequently making you crave and eat more than usual.

Green Coffee is a great way to get started.

These fad diets promise the world to you. But you soon realize that none of these so-called crash diets have helped you at all. Fad diets claim to work and promote weight loss when you avoid eating several types of food or strictly reduce your daily food intake. This is why Garcinia Cambogia is so popular. They probably have even made your problem worse because you starved yourself for a while and now your body is asking for more food to compensate. Everyone who tried any crash diet will likely agree that it is hard to follow no matter what type of fad diet you have decided to try. You may be able to see a little weight loss at first but it is only temporary. People also lose interest soon enough, making them regain any lost weight or gain even more after.

Many outlets have done research comparing Green Coffee vs. Garcinia Cambogia– which both have similar properties for weight loss.

These extracts are absolutely amazing in so many ways.

Garcinia Cambogia is even better than the other ones.

What you need are long-term solutions that you have been trying to ignore all along such as eating right and taking doctor-approved weight loss supplements. The experts suggest a healthy weight loss of ½ to 2 pounds weekly through improved nutrition and more active physical activity. Small frequent meals are better than three big ones daily. Add to that the beauty and value of exercise and you can very well see a new you in no time. Not only can these health habits help you lose weight, they also improve your over-all health and help build up healthy habits that reduces your risk of having Diabetes, high blood pressure, or heart disease. These silent killers attributes to the high mortality rate among the obese population. Phentermine and Garcinia Cambogia are great diet pills you can use for this as well.

Reducing your daily caloric intake is also a good practice to promoting weight loss. Your body can only burn so much throughout the day and anything that is in excess will likely end up as stored fats. Your body needs stored fats, though, in cases of emergency that serves as extra fuel to help you survive difficult situations. However, metabolism slows down as you age, which makes it harder for your body to burn what you eat. By restricting calories to just what your body needs to last you an entire day, you no longer store excess fats which is exactly what you need. So, make the ultimate sacrifice of cutting back on food and resist temptation if you have weight issues.

If you crash diet, you may be able to see sudden weight loss. That is true because you would likely limit or remove carbohydrates in your diet since it is one of the root causes of weight gain. But the problem is that weight loss is just temporary, as mentioned earlier. Starving yourself is never a good solution too because your body will have a hard time coping with such a drastic measure. You will start craving for food because your body does not have the energy it needs to fuel important daily biologic processes. We have been using Garcinia Cambogia for quite some time with good results.

How can you lose weight safely and effectively then? The answer is plain and simple. Change the way you live and the way you eat. But many people find it hard to stick to this lifestyle change because results take too long to be seen that many gets discouraged and go back to their old ways before they even achieve the results they want. Hence, take a weight loss supplement to boost your weight loss effects. Different diet pills have different effects. Some can burn fats while others suppress the appetite. Others work better and provide multiple effects but may be priced a little higher than regular weight loss pills. It won’t hurt if you take one because most diet pills are made using natural ingredients that have been found to lead to weight loss. You can avoid bothersome side effects when you take the right dose and take it properly. These annoying side effects are usually the most common complaints among diet pill users.

If you want to make the most of a diet pill’s weight loss properties, always consult your doctor first so he/she can prescribe you the one best suited for your needs and your body. Aside from that, you can be properly assessed and have everything taken into consideration before suggesting any brand in particular. After all, it is better to be safe than to be sorry. These weight loss pills are sure to work if that is what you are trying to do.

Your excess weight may be a constant cause of stress and worry but never ever try anything that can put your health and your life at risk. It all starts with yourself and your will to turn your life around. Learn to love your body and take good care of it because no one else will do it for you. If you need a little nudge – like a diet pill perhaps – do not be afraid to acknowledge it too and act on it because that’s when you can make things happen.

A Weight Loss Pill With Success Stores(Full Guide On Meridia)

Weight loss has never been so fast and easy.

No matter how much we try to deny it, or ignore, we can’t help but be drawn to people who fit the perfect image. It means that they look cool, cool enough to strut the latest fashion trends without being bothered by jiggly fats and annoying bulges. Unfortunately, not all of us are blessed with the metabolism of our youth, right when puberty just hit us and our metabolism is up to par with our raging hormones. This is a great way to get started with meridia. Imagine that, those were the days. Sadly, gravity sets in and everything goes down. There goes your life as well, especially your social life. It is such a shame that people get bullied and ridiculed because they are fat. We don’t want to be labeled as discriminatory but deep down inside, we often pass judgment to the next person just because he or she is overweight or obese. There’s little we can do about these people, it takes a whole lot more initiative to change an entire society’s mindset. But there is something we can do with our weight. It does not have to be purely for aesthetic reasons, but for a healthy and long quality life in the years to come.

Consult your doctor first and tell him about your plans of supplementing your weight loss regimen with such a drug. If he tells you it is okay, go ahead and start transforming your body and your life right before your very eyes. But before that, you need to be wary of the following considerations:

• Stay away from the drug if you are taking or have taken a MAO inhibitor or if you are allergic to its component, sibutramine.

• Inform your doctor about these conditions:

o high blood pressure

o kidney or liver disease

o underactive thyroid

o history of gallstones

o bleeding disorder

o 16 years old or younger and 65 years old or older

• Inform your doctor about other drugs you are taking like cold or allergy drugs, antidepressants, or painkillers.

• Tell your doctor if the drug was not effective because you fail to lose the minimum four pounds since you started taking the drug or 4-weeks into the added supplementation. These are great diet supplements.

Aside from taking MAO inhibitors, the following conditions also rule out any chances of you ever being allowed to take this drug:

• High blood pressure

• History of coronary artery disease

• An eating disorder

• History of stroke or heart attack

• Taking stimulant diet supplements

• Pregnant or lactating

If you are wondering how to start taking Meridia, of course, seek your doctor first. With his go signal, take it orally once a day.

Why This Weight Loss Pill Is So Effective

And you can take it regardless if you have eaten something or not. It is expected to lose around four pounds during the first month. If you didn’t lose at least that weight, it is best to have a little talk with your doctor once more. Make it a point that you get to have your pulse and blood pressure checked regularly too. You can only continuously take Meridia for two years, not any longer than that. When storing, ensure that you put it somewhere away from heat, light and moisture. This little weight loss pill has been gaining fame precisely for that reason- it helps people slim down(plain and simple). In case you miss a dose, take it at once. But if it is almost time for the next dose, just skip the previous dose. Never take another dose to make up for the one you have missed.

Things to Avoid

• Do not drive or operate machineries.

• Avoid other similar weight loss pills.

• Refrain from taking any cold, cough or allergy drugs.

• Stay away from alcohol all the time.

Remember that the following are the common side effects you’ll experience while you are on Meridia:

• Upset stomach and dry mouth

• Stomach pain and constipation

• Changes in appetite

• Headache, joint pain, and back pain

• Flu symptoms like sore throat, stuffy or runny nose, and cough

• Feeling depressed, dizzy or nervous

• Redness, warmth or a tingly feeling underneath your skin

• Sleeping issues (insomnia)

But if you experience the following more serious side effects, be ready to seek emergency medical assistance such as these signs of an allergy: difficulty in breathing, hives, and swelling of the face, lips, throat or tongue.

• shortness of breath

• fast, uneven or pounding heartbeats

• hallucinations, agitations, tremor, fever, nausea, vomiting, overactive reflexes, loss of coordination, diarrhea, and dilated pupils

• rigid muscles, sweating, high fever, confusion, andfainting

• easy bruising and nosebleeds

• high blood pressure

• sudden numbness or weakness

• chest pain or a heavy feeling on your chest radiating to your shoulder or arms

Like any other drug, Meridia has its pros and cons. You can only tell if it is safe for you after consulting with your doctor. If it is okay for you to take it, then good for you. Losing weight will no longer be that impossible feat that seems to elude you for as long as you can remember.

Are Weight Loss Pills The Answer To Real Obesity? Read This To Find out…

Weight issues are common among people who loves to eat. After all, your body does not need all that food to fuel your daily body functions. What happens is that they end up as stored fats. And once it does, it won’t be that easy to lose them off common problem areas such as your arms, belly, and thighs.

These are the best diet pills you will find.

Among the famous diet supplements out in the market today, Garcinia Cambogia is the most promising one when it comes to getting rid of stubborn fats and achieving a slimmer physique. Reducing your appetite is pretty simple when you know how to do it. That is why we are choosing people like you to participate in this.

If you actually needdiet pills in Canada, make sure you are reading into their contents to see what they contain for ingredients.

This miracle diet pill is well-known for its dual fat action buster properties as well as its ability to curb your appetite. You no longer have to rely on food to make you feel better, or depend on sugar and simple carbohydrates to instantly provide you with an energy boost.

Greater bioavailability of HCA-SX was observed when taken on an empty stomach (Source: An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management ) While HCA extract works as an appetite suppressant, other benefits may be seen when Hydroxycitric acid based supplements are taken on a daily basis.

Garcinia Cambogia is rich in hydroxycitric acid or HCA. It is related to the citric acid found in lemons and oranges. HCA is a potent fat buster and appetite suppressor. It burns fats by blocking Citrate Lyase, the enzyme responsible in making and storing fats. Also, it puts a break on your desire to eat by increasing serotonin levels, otherwise known as the body’s happy hormone. Emotional eaters can greatly benefit from this effect since they no longer have to eat to cope with the various life stresses they face each day. Moreover, it increases a person’s satiety level, making them feel full earlier so they no longer fall to the pitfalls of overeating.

Weight loss pills have always been popular.

People struggling with their weight understands all the difficulties associated with weight loss. But if there’s something that promises to aid their weight loss journey by making things easier for them and helping them reach their goal faster, that’s no other supplement than the pure Garcina Cambogia extract. Garcinia Cambogia have millions of satisfied users over the years, and promises of more in the years to come, more slimmer bellies, more happy people, more leaner arms and thighs, more active lifestyle, and more lives changed by this amazing pill.

This Weight Loss Pill Supports your Passion for Fashion

We all want to look good, if possible, all the time. That means you need to have a killer bod along with some really fashionable clothes. However, just getting that jaw-dropping figure is a major feat on its own, add to that the fact that most trendy clothes nowadays are geared toward the slim and fit population. I mean, just look at those mannequins. They’re actually quite intimidating. And only a handful of shops and brands carry a plus-size selection. And if they do, the options aren’t that promising.

So, if you want to lose inches off your belly or maintain that slim figure, take Garcinia Cambogia. Garcinia Cambogia happens to be the ‘holy grail’ of weight loss, if that’s not enough to make you do a double-take on this supplement. Simply popping the Garcinia Cambogia pill can do wonders on your body, even let you wear clothes you never thought you could now fit in. It is a bit vain if you look at it without understanding the effect of weight loss in a person. In reality, it actually boosts your morale and confidence in yourself. No matter how much we try to deny it, outside appearance does matter when it comes to socializing with others, getting jobs or promotions, meeting new friends, and generally feeling good about yourself among others.

Weight loss pills like that are great for health.

You just can’t imagine how bad a person feels when they are constantly being ridiculed for their weight and other ugly features exacerbated by their heavy frame. With the help of Garcinia Cambogia, you literally transform your life by physically transforming your body. You now get to wear all the fashionable pieces of clothing you’ve been dying to try for so long. And best of all, you not only became healthier but feel better too. You don’t need to be a rocket scientist to know how powerful the Garcinia Cambogia supplement is. It is evident with everybody who gave it a try and are now sporting a new and undoubtedly cool look from now on.

Why Garcinia Cambogia Is Now Going To Facebook

We always had the notion that whatever is being shown on TV is legitimate and lives up to its name. In short, that specific move to feature and endorse Garcinia had its place securely planted on people’s mind. It also gave people who are battling with weight issues another option to address their problem. This product may just be what they are looking for. Maybe it really work, famous personalities will not stick their head out for it if they were not convinced of its potential. They have presented studies and clinical trials that Garcinia Cambogia has been through as proof of its claim. TV has made it possible for people to know about this great product.

This is always true regardless of what you may have been told.

Why Pure Garcinia Cambogia Is Great For Health

What would you say if somebody told you that you could lose all the excessive weight in a couple of weeks just by doing three easy steps? Maybe it’s hard to believe, but it’s not impossible!

The first step would be to buy one of the Nato Garcinia Cambogia supplements. Garcinia Cambogia is the main ingredient of many pills and powders, and its main function is to prevent your body from producing so much fat. It also has the added benefit of making you less hungry on an everyday basis. The second step would be to eliminate all the sugars and starches. You want be able to continue doing this, since it would be very hard on your body, but that’s why we’re talking short-term weight-loss measures. Sugars and starches are the food that stimulates the secretion of insulin in your body.

When you lower your levels of insulin, you make it easier for the fat to leave your system. Along with taking Garcinia Cambogia extract, this should significantly improve the way you lose weight. Lowering insulin has another benefit – it will reduce the amount of water your body retains, and by doing that, eliminate the excess of weight that’s caused by it. The third step of this programme would be to eat more vegetables, protein and fat. You should include at least one protein source in your every meal, as well as a portion of vegetables that are low on carbs, such as broccoli, spinach, cauliflower, kale, cabbage and cucumber. Always make sure the Nato Training Mission is remembered when you are doing this.

The second and the third step will make you lose a significant amount of weight, but Garcinia Cambogia will help you maintain the new number. That’s why it’s important to combine them. By doing all three of them, you should transform into a much thinner person in a matter of weeks. Where To Buy Garcinia Cambogia In South Africa (New Choices). In South Africa, Garcinia Cambogia is very well known by its effectiveness as a dietary supplement. The pumpkin-shaped fruit is native to rain forests of Asia and Africa. It has been used to prepare curries and as a souring ingredient, as well as a natural digestive. As you might’ve supposed, those are not the reasons for its being so popular across the globe. Buying Garcinia Cambogia is a great way to get started.

Purchasing it may be tough for those who are uninformed. Be sure to read up on where to buy Garcinia Cambogia if you want to have the best choices. Hydroxycitric acid, or HCA is the main active ingredient, as well as the main reason for Garcinia Cambogia’s reputation as a weight-loss miracle. It’s a substance whose effect on the human body is twofold. The most important function of HCA is the blocking of another substance called citrate lyase. By blocking the thing that makes it possible for your body to turn carbs into fat, HCA prevents you from storing it. That’s why they say that this supplement will make you lose so much weight.

The second effect that HCA has on your body is the suppressing of the appetite. Find more diet tips at garciniacambogiapure.ca. By increasing the levels of serotonin in your brain, HCA makes you happier and less prone to emotional eating. The two functions put together make Garcinia Cambogia an almost miraculous dietary supplement that could make all your dreams come true, without harming you in any way. Unfortunately, the claims that the supplement has no side effects are simply not true. Various symptoms related to it have been reported. The list includes the following: nausea, diarrhoea, fatty stool, restlessness, headache and rash. Most reported side effects are harmless, although there have been exceptions, such as documented hospitalizations because of liver toxicity.

The most effective garcinia cambogia routines

We always tend to dream big. And we also apply it when we make goals when we are trying to lose weight. But it does not work that way. Anyone who is fat or has been fat knows how hard it is to lose weight. And one of the biggest mistakes an obese person can ever do to sabotage his weight loss attempts is to do everything all at once and expect a miracle to happen overnight. Setting a high expectation on yourself can put a lot of unintended pressure and eventually wear you out.

Among the most effective techniques for getting in shape is to reduce weight securely. Losing a lot of pounds is simple and can be quite rewarding. This has been the verdict of many physicians that examine this topic of diet plan professionally. The reason you must make use of risk-free methods is straightforward. Weight loss pills are essential. Unsafe diet regimen drugs need to be stayed away from and they are not the best types of conditions for the ordinary person. If you believe you can do these things well, you must most definitely check out the most recent diet supplements on the market. These are called weight loss pills.

That is why so many are flocking in droves to garciniacambogia.org.nz.

The cravings decrease approaches they have are very powerful. They additionally induce the metabolic process and raise it to make sure that your body burns fat deposits and gets rid of excess calories.

This is a vital part of lessening the poisons in your body and burning excess fat deposits. If you are thinking about slimming down today, you should acquire a container of these diet plan nutritional supplements so you could obtain your objectives promptly. You do not wish to stand by up until it is far too late. Working out often could help you get a truly fantastic body. Nevertheless, this is usually something that most people are too lazy to do. You wish to be sure you are doing everything in your power to burn fat securely and not need to make use of bad supplements that are dangerous to your physical body. The obestiy epidemic is at http://www.cdc.gov/cdctv/diseaseandconditions/lifestyle/obesity-epidemic.html.

Garcinia Cambogia, a plant that is included in the herbal state is a flowering plant that remains green throughout the year. Although it is native to South East Asia, central and west Africa and India, it is used in almost all the corners of the world for various purposes. The extract from the fruit of this plant is renowned worldwide for its numerous health benefits. In some parts of the world, the fruit of this plant is used in the preparation of curries. Many people across the world today are either using this product or considering using it to lose weight in a healthy way.

Our South African Garcinia Cambogia Supplier Is Fully Stocked

The average person does not take the recommended 10,000 steps per day. The average person does NOT have the time to hit the gym up 5 days a week. The average person does not have time to fuss with food. They have to eat on the run because they are constantly on the run. In a perfect world we all would be able to slow down and spend more time taking steps, hitting up the gym and pondering our food choices.

Since the 1960s when Garcinia Cambogia’s weight loss properties were discovered, it has never left the mainstream market and continues to have a cult following among the weight loss obsessed.

It is not a perfect world.

Here is our favorite site for getting pure Garcinia Cambogia extract.

So what do you do when you have packed on the pounds and need to rid yourself of them? Well you take the one thing that will speed things up for you to keep up with your busy lifestyle. Garcinia Cambogia is the one thing that has been proven to help peel away the pounds and that will fit in with your hectic lifestyle.Garcinia Cambogia is an easy to take supplement that is available in pill form that will help to keep your appetite down and your metabolism up. In this fast paced we need fast paced weight loss methods and this method is an all natural method straight from nature! There is no way to go wrong with this option. You do not have to starve yourself and drink your meals. You do not have to pay the high cost of replacement meals or specialized meals.

Garcinia Cambogia is affordable and available. It is an easy solution to your dieting needs. If your in a hurry and you need an easy solution. GC is a quick weight loss method that can fit in nicely with your busy lifestyle. You do not have to worry about taking those ten thousand steps or trying to make it to the gym everyday. You have your answer. Losing weight is no picnic. It is difficult and stressful. Stress is one of the worst things for weight control. Stress is known to pile on the pounds especially around your belly area. It really is a vicious circle of events. You are stressed about your weight and then the stress causes you to gain weight. Breaking the cycle is the only way to lose the weight. Garcinia Cambogia can be the one thing that can help you to break the cycle. Why? This wonderful compound can take the stress out of dieting. When you know that you are taking a pill that has been proven time and time again in clinical trials to help people lose weight it takes the stress out of losing weight. Most people worry about dieting. They worry about the food that they are eating. They have to deal with the guilt of the slip ups when they eat something they should not.

GC will help you to avoid the slip ups because it is a potent appetite control method. Garcinia Cambogia also helps to improve the way your body burns fat. Once you know that you are taking aproven supplement it takes the worry and stress right out of dieting. Garcinia Cambogia is the key to successful dieting. Get rid of the stress and get rid of the belly fat! Get rid of the stress and slim down. Get rid of the stress by taking a proven winner in the battle against extra pounds! When you are done with “go nowhere diets” and done with the guilt of not being able to take offthe weight you will be able to recognize the true value in this all natural weight loss measure. Give yourself a break and add this supplement to your dieting arsenal.

Australia Now Has The Best Version of Garcinia Cambogia

It is a small fruit of tropical origin that can be described as resembling a smaller pumpkin. The color of the fruit varies depending on the area and the stage of growth, but it is mostly green and yellow. It is used in both traditional medicine and cuisine because it is tasty and healthy. It can be prepared in many ways, but the most common one includes mixing it into curry paste.

The fruit has been discovered by us Westerners not so long ago. Most of us know it for the beneficial effect that it has on the process of losing weight. Although these claims have not yet been proven, GC is allegedly a fruit that has such an effect that it prevents you from gaining weight. As an ingredient of many dietary supplements, it serves two main purposes. Its active ingredient blocks a substance that causes you to stop accumulating weight in your body.

This is the function that most people know of, and also one of the biggest reasons why it is so popular. The second most important function is preventing you from regaining the weight you already lost. Many people recommend using these products, but there are differences depending on the manufacturer. Some put a lot less HCA in their products, causing them to be less effective in the weight loss process.

When deciding which of the products you should buy, always refer to the ingredient list and check the percentage of HCA it contains. That should help you make the right choice. Here is our best version of Garcinia Cambogia. If you are looking for the best way to lose weight, look no further. You will find that the solution is a quite simple mix of the already existing ones. The thing about weight loss is that it inevitably implies a healthy lifestyle.

Like with so many other things, you cannot get permanent results without committing to your goals. This is why you will need to start exercising, eating healthier and living happier if you seriously want to get rid of all that fat that has been accumulating on your hips, waist, thighs, arms and legs. You could, of course, try to let the supplements do all your dirty work.

Taking Garcinia Cambogia pills to magically lose weight sounds amazing, but it just won’t work, and you know it. If you are one of those people who believe everything that is being said on TV, then you might even think that Garcinia Cambogia is really that great. On the other hand, if you have some common sense, you will know that life just isn’t that perfect. Nothing, not even Garcinia Cambogia, can solve your problems that easily.

If you just try to make some positive changes in your lifestyle, you will eventually see the difference. Introducing a regular exercise regime is a significant factor in the weight loss process. Working out on a regular basis will help you lose weight, reduce your stress levels and maintain a good figure.

Garcinia Cambogia is a tropical plant found in Southeast Asia and certain parts ofAfrica and is traditionally used by the locals as a food flavor to impart sourness and tartness to curries and gravies.

Garcinia cambogia is a citrus fruit that grows in Southeast Asia.

The most important factor of them all is healthy eating. It involves resisting your cravings, even when it is really tough to do so.

This takes a lot of effort and strong willpower, but you shouldn’t get discouraged because it is far from being impossible. Unlike taking supplements like GC, the combination of a healthy diet and exercise will make you thinner and happier. Having a bunch of obligations, a full life and a great figure often seems like an impossible mission. However, like with many other things that are a big part of your life, this issue can be resolved by taking a shortcut.

Pure garcinia cambogia canada stores

Many of us here at the Jefferson Institute simply have one plan: to make life as easy as possible for everybody involved. If you are somebody who has been thinking about coming up with a new life for yourself, make sure you do it wisely with all of our nutritional concepts. The institute simply loves it- because we are Jefferson.

Amaranth is great for this especially if you use the seeds in your diet.

The Art of Weight Loss with Garcinia Cambogia(Before And After Photos)

Weight loss is often a controversial topic. It stirs up very powerful feelings from many people, especially the ones who were once overweight and experienced what it was like to be trapped in the cycle. Let’s all admit it, losing weight is never easy.

Many people are complaining about a lack of nutrients in these products, but most of their claims are unfounded.

It is why a lot of the heavyweights out there either quit or fail. The most trusted solution in losing weight is to cut back on your food intake done alongside a very strict exercise regimen. Unfortunately, not all of us have an iron will and the commitment to put in long hours of doing rigorous exercise and passing on desserts.

The entire point is to compare it to Hydroxycut, however, which the Jefferson Institute really doesn’t like doing(ever).

You really have to study this stuff all the time in order to understand it.

Weight Loss Pills That Work

If you have tried the long way but failed, there is something else you can do. Lose weight with class by taking the Garcinia Cambogia pill. Unlike other diet pills that stimulate your colon, so you end up spending long hours in the bathroom, Garcinia Cambogia works differently. It works directly on your body fats, effectively melting and burning them apart from preventing the storage of new ones. As a result, you need not always be stinky to look good.

Just pop the pill three times a day and wait for the rich Hydroxycitric acid (HCA) supply to work.

There are many different ways to go about this, however.

Many people compare exercise to an activity that you don’t want to do.

That is why we researched these diet pills that actually do work if you give them a chance.

They really are an all around god-send in terms of effectiveness.

Aside from being a fat buster, Garcinia Cambogia likewise increases the supply of serotonin levels in the brain resulting to higher satiety levels and a curbed appetite. Overeating will no longer frustrate you and lead you back, time and again, to square one. And because there’s plenty of serotonin up in your head, it brings about a better mood and disposition. You need not fill your mind with thoughts of food all the time to cope with life’s stresses.

If you are fed up of being a weight loss failure, it’s time you give Garcinia Cambogia a try and be one of the countless satisfied users who were able to transform their lives for the better with the help of this powerful pill.

Many years ago, when the whole world was still oblivious to the existence of Garcinia Cambogia, there was the Malabar tamarind. This amazing tree fruit resembling a pumpkin has been used in cooking to make dishes taste sour. Aside from that, it was also used as an effective tummy remedy for people suffering from a tummy ache. It is an endemic fruit to many Southeast Asian and African countries, especially Malaysia and India. But over time, natives to these countries started to notice that those who always consumed or take Malabar tamarind also began losing weight. That’s when this ordinary fruit captured the attention of scientists to conduct a research on its weight loss properties.

Their studies proved to be a success and Garcinia Cambogia was introduced to the whole world as the “holy grail of weight loss.” They found out that the Malabar tamarind was rich in hydroxycitric acid or HCA. It is the component responsible for realizing weight loss on people, and also became the main active ingredient of the pill. From then on, people who have been struggling with weight issues can now lose weight conveniently without having to do anything at all, just simply take the recommended dosage of the supplement. Garcinia Cambogia became an effective tool in burning fats and suppressing a person’s appetite without leaving them hungry or lacking in energy for the day.

The Garcinia Cambogia that we know today is the most popular diet supplement out in the market. People from all walks of life have enjoyed real weight loss results because of it. And this wonder pill does not show any signs of slowing down since it remains to be the bestseller of all. It even achieved the status of becoming a household name. It’s how big Garcinia Cambogia has become. But the real secret to its success lies with the Malabar tamarind.

Having excess fats makes people look fat. Layer after layer of this annoying grease covers your entire body, even your internal organs. Too much fats in the body does not only have a negative effect on your appearance, but compromises your health and wellbeing as well. All of us don’t want to be fat. However, some people appears to be predisposed to having lots of it and have a hard time in getting rid of it too. Too bad for them because most likely, they’re also the very same people who have been spending all their time and fortune in looking for ways to lose weight for real.

By now, we all know how fats damage our body. Today is always the best time to act on it and start to become an effective fat burner machine. After having tried all the weight loss trends that has flocked the market, taking the Garcinia Cambogia supplement will prove to you that you can finally say goodbye to all your stubborn body fats for good without exerting any extraneous effort at all. Garcinia Cambogia takes pride in being an excellent fat buster and appetite suppressant. To get rid of fats, Garcinia Cambogia directs all its efforts in burning fat and preventing your body in storing more of it. And because it curbs your appetite, your body will tap existing fat stores with any additional demand for energy and not make you eat more. The increase in happy hormones also help a lot because it not only increases your satiety level but improves your mood too. You already feel better about yourself and no longer wallowing about your heavy physique.

Garcinia Cambogia In New Zealand: Details

Are you considering surgery to help you lose excess body fat? Are you ready for all the complications that can go along with weight loss surgical intervention? Before you make that commitment to go under the knife you should look in to a dietary supplement called Garcinia Cambogia. Be sure to check out www.trygarciniacambogia.co.nz for even better tips!

Garcinia Cambogia is a viable alternative(http://www.livestrong.com/article/153741-vitamins-to-help-lose-weight-boost-the-metabolism/) to surgery when it comes to losing weight. Having too much fat on your body can actually hurt physically and it is understandable that you might want to look at surgery as a quick fix. Unfortunately the side effects of most types of weight loss surgery can be long standing, even permanent. Is that how you want to spend the rest of your life? Aside from visible physical scars many people find surgery leaves them never being able to digest foods properly, resulting in uncomfortable visits to the bathroom.

Garcinia Cambogia from http://www.doctoroz.com/slideshow/vitamin-essentials offers a strong alternative to permanent weight loss, permanent fat loss, without severe side effects. Concentrating on eating a healthy diet, with at least three meals a day, and including Garcinia Cambogia it will not take long to see dramatic results. This supplement will also help reduce cravings so you will snack less. You will burn fat effectively from all parts of your body at the same time. Simple exercise can help you stay fit and tone, tightening up areas that may have been stretched by too much fat. This is why Amaranth is so great.

Surgery for weight loss can leave both physical and mental scars and it is not always the only best choice for getting rid of excess body fat. Too much fat can lead to serious health problems but so to can surgery. It is worth trying this supplement that so many others have used with great success. Talk to your doctor about it first before any surgery.

It’s Friday night and you’re heading out to the movies with friends. You have waited with great anticipation for this new movie to arrive; it’s going to be the perfect start to the perfect weekend. At the counter you order your ticket and the smell of fresh popcorn gets your taste buds watering. Wait, you’re on a diet you tell yourself. Should you have that popcorn and a drink to wash it down? Suddenly your perfect start to the weekend seems to be fading. Don’t let this happen to you. If you have included Garcinia Cambogia in your diet plan you can enjoy that popcorn.

Why should a night out with friends be ruined because you are afraid to treat yourself to a simple food because it might make you fat? You need food of course to live and you should not have to ever deny yourself. Making healthy choices including keeping treats to a minimum helps, but treats should be allowed none the less. Garcinia Cambogia can help you feel less stressed about treating yourself.

Garcinia Cambogia, because of its fat burning properties, allows you the luxury to treat yourself on those occasions where you would rather not have to worry if what you are eating will make you put on excess pounds. Yes it is important that you make healthy food choices but treating yourself to fun foods should still be a fun and acceptable activity. Celebrations should include good food, even fun food with little to no real nutritional value.

A night at the movies just seems to be made better by munching on a reasonable size of popcorn and a beverage to wash it down. Don’t deny yourself a little freedom with your diet; include Garcinia Cambogia in your journey of fun and friendship and life.

Amaranth can be used for a lot of purposes like this.

Garcinia Cambogia supplements and their importance

Do you feel sluggish and bloated? Are you tired all the time? Do you get out of breath just climbing the stairs? All these things point towards obesity and an unhealthy way of life. We should all be able to climb the stairs and not even feel it, but for most of us, that doesn’t happen. When you are carrying excess weight, daily tasks become difficult and sometimes, they are even too great a challenge to overcome. You might find that you stay on your couch in your work clothes for an entire evening because going upstairs to get showered and changed leaves you breathless and feeling rotten.

You can change this. Its easy with garcinia cambogia, simply take it and lose weight. You really can. You just need a little support and that’s where Garcinia Cambogia comes in. It is a natural weight loss aid made from fruit that will help you shed your excess pounds. You will begin to feel better and be more active in no time Garcinia Cambogia is scientifically proven to support weight loss. It will enable you to get going on your weight loss journey. Combine it with a healthy diet containing plenty of fruit and vegetables and as little fried food as possible and with gentle exercise, and you will see yourself looking better in that mirror every morning.

As you exercise more and eat more healthily, Garcinia Cambogia will work harder to burn off fat and to increase your metabolism. It will help you achieve your weight loss goals without you having to dedicate your whole day to the efforts. Start out small with just a few pounds per week, and as you lose more and more weight, you can increase those weekly weigh in targets. Garcinia Cambogia will continue to work to help you lose more weight than exercise and diet alone.

The greatest weight loss myth is that if you eat less you will lose weight. Although this does work to a certain extent, as in, at first, you will lose weight, slowly, your body adjust to the new calorie intake and goes into starvation mode. It convinces itself that you need to stock up as food is scarce, a throwback to our time as cavemen. What it will do is stockpile fat and sugars to keep it going in times of need, and so in fact, you will put on weight.

The best way to avoid this is to burn off more calories than you eat. On a diet, you should be aiming to eat around one thousand six hundred calories, and trying to burn off around four hundred calories each day. This can be really challenging, particularly if you have a busy lifestyle and getting to the gym is not one of your priorities. This is where Garcinia Cambogia can help you. It is a diet supplement that works to burn fat and increase your metabolism.

Where as in a normal day, you might use two hundred and fifty calories just through your usual commute to work and darting about the office, Garcinia Cambogia will make that small amount of exercise work harder for you and so will enable you to lose weight more easily. Now just by walking to work or through the park, you will lose a lot more calories than before, making any extra exercise unnecessary.

It has been scientifically proven that Garcinia Cambogia aids weight loss and there are millions of people all over the world who swear by it. And because Garcinia Cambogia is made from natural properties, you are less likely to get an adverse reaction to it unlike chemically designed weight loss supplements.

NEW WEIGHT LOSS PILL UPDATE: Garcinia Cambogia Is Canada’s Favorite Supplement

When Pure Garcinia Cambogia supplements reduce belly fat, there will be that much less strain on your heart. Those with big bellies cannot normally run very fast or very far without becoming winded.

Many such diet medications have been abused in the past.

Their lungs are not the problem.

Many people have been talking about these new weight loss pills because of their proven health benefits.

Their heart is the problem. It tires from having to carry too much, too far, and too quickly. Exercising the heart can be a good thing, but straining it or overworking it is not, and that is what having a big belly can do.

Here Are Some Of The Common Sizes:

An excess of belly fat is not flattering, nor is it healthy, and it can be downright dangerous.

Although losing fat too quickly is not always a good practice, you still want to lose belly fat, or at least an excessive amount of it, as fast as you can, which is why it may be a good idea to give Garcinia extract a try. Try it for at least a month to see what can happen.

You may find dieting a very boring routine. Indeed it is tough for most people. In general, people don’t see instant results and they will start to doubt themselves. It is only normal for people to that. They do not know the secrets of dieting and that is why they are struggling to lose weight. As with anything else in life, dieting in the correct way will lead to quick and effective results.

For example, most dieters who have failed to lose weight quickly do not take any supplements. What they do not realize is that supplements significantly help with losing fat. Garcinia Cambogia is perhaps the best fat-buster in today’s world. It is so effective that dieters are giving it so many positive reviews.

GC helps you in burning extra fat in your body. Basically, that means all the excess weight will be used up and you will achieve a leaner and perfect body. It does so by increasing your metabolism rate. By increasing your metabolism rate, your body’s calorie expenditure will be higher than normal and will burn more fat in the process.

Consuming organic food obviously does good to our body, not just with the nutrients and fiber it contains, but of what it does not contain, like chemicals, pesticides and other additives. Unknowingly, we are harming our body in our attempt to eat better.

Unfortunately for some, organic also spells out expensive, or not that easily accessible. Fresh fruit and veggies also has a shorter shelf life, which affects some people’s decision making when doing their groceries. Some prefer to be practical, even though they know that what they are eating can be harmful to them and their family in the long run.

So, when eating right is not that feasible for you as you try to lose weight, other options are still up for grab.

So do you screen using transferrin saturation (which is awfully sensitive and not very specific), the HFE gene (which is too expensive), or a serum ferritin (which picks up the people at risk for cirrhosis, albeit late, and is also up in acute or ongoing liver abuse/disease)?

Diet supplements are convenient for all. Diet pills like Garcinia Cambogia, is a practical choice for most weight loss fanatics because it is backed up by years and years of research, and a long list of successful stories from its previous users. Garcinia Cambogia’s main ingredient, hydroxycitric acid (HCA), can assure you to burn your fats and curb your appetite at a reasonable amount.

The consumption of Garcinia Cambogia has also been cited as safe for the public because it is all-natural. Most Garcinia Cambogia brands are pure extracts and does not contain fillers. It makes you feel good knowing that you are not only making an effort to boost your confidence by looking great, but also by taking better care of your body to prevent getting seriously sick and to be there for your family for years to come.

It is common knowledge that trying to lose weight can be stressful for many. You go through so many changes, that it can mess with your emotions. Almost all of the time, you want to keep on doing something, because you feel like doing nothing is being lazy, which is the reason why you are fat in the first place.

Not all the time, you have to be so pumped-up and always want to get going and get things done. When you are facing such a challenging task, it is acceptable to chill and relax at times too. It will give you time to evaluate your progress, re-evaluate your goals and plans, and just plainly relax and unwind. Free yourself from stress and worries from time to time. You are only human and deserves to rest too.

But then, you can still actually keep up with your weight loss efforts even when you are laying low and relaxing, with the use of diet supplements. Garcinia Cambogia achieved the honor of being named as the holy grail of weight loss. A famous health and wellness guru, who has his own popular television show, unabashedly proclaimed his profound respect and awe to the magic brought about by Garcinia Cambogia. He strongly vouches that the right use of Garcinia Cambogia will not only transform your body, but your life as well.

Garcinia Cambogia is packed with hydroxycitric acid, (HCA), found in the rind of the Garcinia fruit. HCA is responsible not only for the dual action of the pill at burning fats and suppressing your appetite, but in increasing your serotonin levels too, and controlling your cholesterol and blood sugar levels as well. With this in mind, your worries will be appeased and you will be comforted by the fact that safe and surely no effort weight loss is achievable with this miraculous diet pill around and at your disposal.

The Science Behind Of New Zealand’s Garcinia Cambogia Extract

It might seem like a no-brainer, but eating less is surely the best way to avoid excessive weight gain. If you eat less, your body will be able to use everything to fuel and energize you, and leave no more room for extras for storage. But we all love to eat. Who doesn’t, right? Over the years, eating has evolved to become a past time and stress reliever. With the amount of work and stress we face each day, we strongly feel that we deserve that second helping of food, or overindulge with your favorite treat.

For some, eating is a way for them to feel better. You might not be able to please everybody, but you definitely feel better once you eat your sweet fix. Weight loss is not easy to pull-off. So, if you want to spare yourself from all these troubles, manage your weight and control your cravings.

If you are already in deep trouble, which means your weight is highly controversial, then you must start taking action to lose all that is excess off your body. If you do not have the time to prepare healthy and nutritious meals, or hit the gym for a workout session with your trainer, the next best thing then is to take diet pills.

Garcinia Cambogia will not leave you hanging. It will take care of your excess weight issues, and let you relax while it does all the hard work. Garcinia Cambogia is even highly-promoted by a famous health and wellness guru as the holy grail of weight loss. Surely, Garcinia Cambogia is that superior and powerful to get his thumb of approval.

For years to come, Garcinia Cambogia would still always be there to lighten up your load. Many obese people would forever be thankful for the miracle pill that is Garcinia.

Do not be overwhelmed by everything outside your control. You are not a superhero who has magical powers, and a great script and costume to go along with it too. You have your limitations, so you must learn to accept it. Take better care of your body. It is the only thing that will stick with you for the rest of your life.

Do not neglect yourself and your health. How can you cope with the challenges posed by weight loss if you are not in your best condition? Be your number one fan. Learn to motivate yourself in the face of challenges. Nothing is solved overnight. And there are plenty of ways that you can take to get to your goal. Do not limit yourself, instead, explore all possibilities.

Keeping up with your weight control plan can be a challenge but if you add weight loss pills to your plan you may have a much easier time. Weight loss pills that are all natural will not really effect how you feel as far as making you feel jittery or nervous. Diet pills can actually help to improve your mood. Diet supplements are the perfect additive for a busy stay at home mom’s diet. They are the solution for anyone that wants to get in shape or stay in shape but is short on free time.

There is nothing worse than not feeling good about yourself. It can affect every area of your life. Of course if you are a young parent it will also affect how you parent. You want your children to enjoy their time with you whether that time is spent at home in the yard or on the playground at the park you want to be able to keep up and feel good about yourself. Being overweight can surely be a way to not feel good about yourself but more so it can keep you from having the energy that you need to keep up with the kids.

When you are overweight your body just feels sluggish. You do not want to go out and play. You do not want to have relations with your partner. You tend to feel uncomfortable with your body which makes you feel less sexy. It can put a strain on your relationship with your partner.

How To Take Garcinia Cambogia For Maximum Results

We all want the best for ourselves and our family. Who wants to settle for second best, right? Of course, nobody in their right mind would do just that. But what we do not know, most companies lure us with catchy advertising and promotion, but not really deliver quality products. These companies grow big as a business by downplaying the drawbacks of their products, and capitalize on flashy ads and high paying celebrities to endorse their goods and services.

When it comes to healthcare, it can be dangerous to compromise your health with just second best products. It can mean life and death to some. That is why investing in a product with a proven track record is the only way to go.

If you are planning on dropping some weight, Garcinia Cambogia is the only diet supplement that can guarantee you safe and real weight loss. Garcinia Cambogia pills are packed with hydroxycitric acid, (HCA), which is its main ingredient and is abundant in the rind of the Garcinia Cambogia fruit. HCA inhibits the enzyme ATP-citrate lyase from further converting and storing fats as future energy. Aside from being able to burn fats and prevent new fat storage, a person’s appetite is also strongly decreased because of the increased glycogen levels, which signals the brain that a person is already full.

Garcinia Cambogia also improves your mood by increasing the serotonin levels in the body. This happy hormone also has a positive effect on your eating habits, since happy people usually do not resort to eating to make themselves feel better.

If you are on your journey to weight loss, make it a positive and happy experience by relying on products that has a multitude of effects that can make your efforts worthwhile. Not all who go through some major body overhaul has to necessarily feel deprived and terrible. It is up to you to choose products to aid you on a smoother transition.

If you really want to look good, the first thing you have to assess is your looks. No matter how much we try to make ourselves believe that our physical appearance is not that important, and it is our personality and inner beauty that really matters, apparently not all of us are on the same page. There are still plenty who look for the superficial things in life, and glorify them. For some, it meddles with their confidence and makes them feel less worthy of another’s attention and affection. Check out even more at NIH.gov.

Thankfully, plenty of medical breakthroughs paved the way to the birth of certain wonder drugs. These products captured our interests with its amazing properties that drastically changed people’s lives. Of course, weight issues would always be dragged when it comes to looking good. You have to be at a particular size to fit in with the crowd, and the image of beauty set by society. So, there’s no more need to wallow over your insecurities and embrace all the changes your body will go through for your real beauty to blossom and shine.

Garcinia Cambogia, the holy grail of weight loss, is considered the best diet supplement there is. It is jam-packed with hydroxycitric acid, (HCA), which effectively burns fats and curbs your appetite. Weight loss is no longer an unreachable dream, but a realistic goal.

Garcinia Cambogia definitely guarantees only the best through tried and tested weight loss results. It delivers its promise to its users, and leaves no room for regrets and second doubts. After all, it won’t smother the rest of the competition if it is not superior over all of them. Weight loss can become a fun journey. Garcinia made sure of that by raising the happy hormones circulating inside your body. This effect would become even more phenomenal as you see how good you look after at least three months of taking this miracle diet pill.

Jefferson Agricultural Institute is a place of learning with the mission to better the current agricultural studies and findings we see in modern farming. With goals to heighten our understanding of nature and farming, with over 100 years of knowledge and experience. They have thousands of students and classes, with eager professors. They not only study the importance and farming practices, but also the grown ingredients we can find in things like vitamins, diet supplements, and more.

Pure garcinia cambogia canada stores

It’s no secret that people today are TOO FAT!

Did you know that fat cells secrete cytokines that increase systemic inflammation, disease and aging? (73,74,75).

The double whammy comes from elevated blood glucose levels, that also dramatically increase inflammation (63,65,75)

AS WE AGE, INFLAMMATION BECOMES THE KEY CONSUMER OF NAD+ AND LEVELS DROP (54,67).

By age 60, we have 1/2 the NAD+ as in our 20’s (21,57)

Declining NAD+ leads to metabolic dysfunction, age-related diseases and is a key contributor to the aging process(21,22,24,40,41).

As we age, this become a viscous circle

LOW NAD+ -> DISEASE & AGING -> LESS EXERCISE -> HIGHER BLOOD SUGAR -> LOWER NAD+

If you are over 40, and your fasting blood glucose level is >85mg/dl, you are pouring gasoline on the inflammation fire(63).

Understanding the role NAD+ plays in aging can help you REVERSE this circle and combat the effects of aging .

Not just weight and blood sugar levels, but Diabetes, Cardiovascular Disease, Cancer and even aging itself are influenced by lower NAD+ levels (21,22,40,41).

Now researchers are discovering what you can do to elevate your NAD+ levels to fight back. Here’s some of the topics we cover:

  • WHAT IS NAD+
  • AMPK – Stimulates NAD+ Production
  • INFLAMMATION – consumes NAD+
  • BLOOD GLUCOSE – High Levels Increase Inflammation
  • EXERCISE – Stimulates AMPK and Lowers Inflammation
  • KETOSIS – Stimulates AMPK and Lowers Inflammation
  • BHB – Key signaling metabolite in ketosis
  • MCT OIL – Boosts BHB
  • NAD+ Precursor Supplements (NR, NMN)
  • AMPK Activator Supplements

WHATS THE SECRET

There are several things covered here that seem like a “Secret”, because they aren’t talked about by those just looking to sell pills or get clicks to their overhyped stories.

But I know that truly understanding this article can change people’s lives. I’ll start with this one:

You DON’T have to take some pills to boost your NAD+

Just spend a little time learning about the science, so you can best tailor your nutrition and exercise plan to take advantage of the recent research breakthroughs and boost your NAD+. A little, or a lot – it’s all up to you.

Having a well defined mental image of what increased NAD+ levels do for your health, rather than some vague idea of “it’s good for you”, helps motivate people to stick to their diet and exercise programs.

And that is the goal of this post – to let you know there are many things you can do to raise your NAD+ levels to achieve a more youthful and energetic body.

WHAT TO DO

It’s pretty simple once you understand the science behind NAD+ and why it drops as we age. The prescription is:

  • Periodic Carbohydrate Restriction – Ketosis
  • Exercise

The goal is periodic ketosis, combined with HIIT to maximize AMPK and boost NAD+ levels, restoring the healthy metabolism you had as a teenager. Weight Loss is just a side effect.

Even if you have no interest in changing your diet or exercise regimen, and only want to learn more about NAD+ and perhaps take a NAD booster supplement like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN), you still need to read this page to better understand how critical it is to get your NAD+ up.

A LITTLE KETOSIS

It’s well known that Calorie Restriction (CR) can extend longevity by 30–50% in many mammals (32), but is not a realistic therapy for most humans.

Fortunately, you don’t have to starve yourself.

Researchers have found it is the production of ketone bodies, or Ketosis, that occurs when strict Calorie Restriction is imposed that provides the benefit in lowering inflammation and boosting NAD+ (3,9).

Ketosis is a metabolic state in which fat provides most of the fuel for the body.

It occurs when there is limited access to glucose (blood sugar), which is the preferred fuel source for many cells in the body.

Glucose is usually the brain’s main fuel. However, unlike fatty acids, ketones can cross the blood-brain barrier and provide up to 70% of the brain’s energy needs when glucose levels are low (3).

Ketosis is most often associated with ketogenic and very low-carb diets, but can also occur under Calorie Restriction, or any of the diet plan where carbohydrate intake is insufficient to supply blood glucose requirements. (3, 4, 5, 6).

When carb intake falls below 50 grams per day, the lower blood glucose levels cause the Pancreas to signal the liver to process fatty acids, from the blood stream and from body fat, where they are processed into ketones to provide energy.

A Ketogenic Diet is an easier alternative for putting the body into Ketosis than severe CR, and is great for boosting NAD+, but many people still find it difficult to adhere to.

In fact, this recent study found more benefit from cyclical than from full time ketogenic diet (71).

This chart shows production of the ketone body BHB. Note the huge increase in those subjects on the cyclic Keto diet (red). Read about the importance of BHB below.

Conclusion: Ketones become the main source of energy for the body and brain when carb intake and insulin levels are low, and are likely the reason CR extends health span.

A LITTLE EXERCISE

Fortunately, it’s really just 1-2 hours a week. Researchers are finding that 2-3 short bouts of High Intensity Interval Training (HIIT) is far more effective at lowering inflammation (and increasing NAD+), especially among older adults (55)

Exercise is not actually required, but it is very effective at boosting NAD+, especially when performed at the right time – when blood glucose is low (see HIIT below, or here).

Hours a day of grinding endurance training does not boost NAD+ and can even be counter-productive (55).

Oz recommended use of garcinia in his show, Garcinia Cambogia went through a laboratory test.

You’re not trying to “burn fat”, but activate AMPK, which drives creation of NAD+.

HIGH BLOOD SUGAR INCREASES INFLAMMATION, LOWERS NAD+, AND SHORTENS LIFESPAN

Elevated blood glucose levels increase inflammation, contributing to disease and aging.

You can predict death more reliably by blood sugar level than you can by age.

Studies have found blood glucose levels even at the normal range can have a significant impact on brain atrophy in aging. (Neuro Science News)

Incidence of disease starts to increase when fasting blood sugar rises above 85 mg/dl (63)

A study of 46,000 middle-age individuals and found more than 80% had fasting blood sugar of 85 mg/dL or greater. (64)

This means the vast majority of aging humans today endure chronic cellular damage associated with elevated blood sugar(65).

The link between Blood Glucose levels and inflammation is well known and explored more here and here.

More than 80% of americans have high blood glucose levels and are slowly poisoning their body!

INFLAMMATION DRIVES DISEASE AND AGING

Chronic, low-grade inflammation is recognized as a major characteristic of aging.

This phenomenon is so pervasive that the term inflammaging has been coined to emphasize that many major age-related disabilities, including cancers, susceptibility to infections, and dementia have immunopathogenic components (31).

When we are injured, inflammation is the body’s first line of defense against invading microbes; but in old age inflammation attacks healthy tissues.

Chronic inflammation is a direct cause or major contributor to almost all aging-related diseases

Arthritis. The old view of arthritis was that the cartilage that cushions and lubricates our joints wears away with years of use. Now it is recognized that osteo-arthritis has the same roots as rheumatoid arthritis. It is an auto-immune disorder, the body’s immune system turned traitor against our bones and cartilage.

Atherosclerosis. The old view of coronary heart disease was that over many years, cholesterol deposits on the artery walls in the same way that mineral deposits build up inside a water pipe and gradually come to clog the pipe completely. Now it is recognized that inflammation plays an essential role.

Cancer. The old view was that there are random mutations that cause the cells to disregard regulating signals from the body and just continue replicating and growing out of control. Now we realize that cancer is a failure of the body’s immune defense system. Cancer mutations themselves are not steady and random, but are ramped up as we get older by chronic, systemic inflammation.

Alzheimer’s Disease. This is the latest paradigm to shift, highlighted in an this article in the MIT Technology Review about the work of Harvard Med School Professor Beth Stevens. Now we are beginning to see that glial cells “go rogue” and begin—unexplainably—to destroy nerve connections that are healthy, even essential for the brain’s function.

WHAT IS NAD+

NAD+ stands for nicotinamide adenine dinucleotide. From simple bacteria to mammal including humans, Life as we know it cannot exist without NAD+.

NAD+ is required for our mitochondria to burn glucose to power the basic functions of all our cells, and also plays a key role in signaling with our cells.

It has now been demonstrated that cellular NAD levels decline with age and disease (54).

This decline impairs mitochondrial function, playing a crucial role in the development of metabolic dysfunction, age-related diseases and that this decline is both a consequence of and contributor to the aging process. (24,53).

A vicious cycle exists in which molecular mechanisms involved in the aging process, such as oxidative stress, DNA damage, senescence, and inflammation, lead to tissue NAD decline which subsequently exacerbates the processes that caused its decline in the first place.(24,53,54)

  • NAD levels decline precipitously with aging in mammals and humans, and are strongly negatively affected by multiple disease and stress processes including obesity. At advanced ages these levels are a tiny fraction of what they are in young people.
  • Maintaining a high level of constitutive NAD+ in the body is critical for maintaining health and functionality, for averting or reversing a number of deleterious disease phenomena, for energy and vitality, and possibly for extending life spans in humans.
  • The rate of DNA damage increases significantly with aging, increasing demand for NAD+ for DNA repair. However in general, the reasons for age-related decline in NAD are not well understood.
  • It has long been known that many deleterious disease phenomena can be prevented or reversed by promoting higher levels of NAD in animal models. There appears to be ample evidence that this approach is generally safe.

Conclusion: As we age, declining NAD+ is a key contributor to illness, disease and deteriorating health

WHAT DEPLETES NAD AS WE AGE?

Our bodies do create NAD+ from Tryptophan in a 7 step process termed “de novo”. But this is a very small quantity and not thought to fluctuate much depending on demand.

By far, the greatest source of NAD+ is thru the salvage pathway. That is, recycled from NAM, NA, NR, or NMN.

The entire NAD+ pool is recycled nearly 3 times every day (21)

When we are young and have high levels of NAD+, it is mostly consumed as part of normal cellular respiration process – that is, oxidation of ATP for energy.

So where does all this NAD+ go when we age?

Does the salvage, or de novo creation pathways break down? Not really.

The problem is, as we age there are more demands for NAD+ from 2 sources:

PARPs repair damaged DNA strands, which increase as we age. A popular aging theory holds that DNA damage is the cause of aging.

DNA damage is repairable, but PARPS consume up to 80% of available NAD+ in older humans, meaning it is a major cause of NAD+ shortage, leaving less NAD+ for cellular respiration, fighting inflammation, and disease (21)

PARP activity is reported to be a major consumption pathway for NAD+ (29)

CD38 is an enzyme that responds to inflammation. As NAD+ levels drop while aging, CD38 levels rise in response to inflammation. Its main function is metabolizing NAD+ (25)

As we age, demand for NAD+ from PARPs and CD38 greatly increases, leaving less and less NAD+ for our mitochondria to perform the basic task of energy production.

No wonder we have less and less energy as we age, and look at our grandchildren with such envy!

AS WE AGE, INFLAMMATION BECOMES THE KEY CONSUMER OF NAD+ (54).

NAD+ is constantly being created and consumed, with the entire NAD+ pool being recycled every day, primarily through the salvage pathway (21,54)

NAMPT is the rate‐limiting enzyme in mammalian NAD+ salvage pathway, converting Nam into NMN as the first step for maintaining NAD+(54)

Both, aging and obesity impairs NAMPT‐mediated NAD+ biosynthesis.(54)

Chronic inflammation induced by prolonged oxidative stress and inflammatory cytokines also reduce NAMPT and NAD+ levels in multiple tissues (54)

NAMPT is down-regulated by over-eating and sedentary lifestyle. Obesity, high blood sugar levels, and aging decrease NAMPT-mediated NAD + biosynthesis (20,54).

Fasting and exercise up-regulate AMPK, which stimulates NAMPT to metabolize more NAD + (20,54)

Conclusion: NAMPT is the rate limiting enzyme necessary to continuously renew NAD+ .

AMPK CONTROLS THE AGING PROCESS

AMPK is both a sensing and signaling enzyme. It senses ATP activity in the mitochondria – basically, energy levels. When blood glucose levels are low, such as with CR or Keto diet, ATP activity is low and AMPK signals NAMPT to create more NAD+ (19)

The December 2011 e-publication AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network makes the point that control of Nrf2 along with control of other key pathways by AMPK drives aging.

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified cellular housekeeping are the hallmarks of improved healthspan and extended lifespan. AMPK signaling is involved in the regulation of all these characteristics via an integrated signaling network.

Many studies with lower organisms have revealed that increased AMPK activity can extend the lifespan.

Furthermore, inhibition of NF-κB signaling by AMPK suppresses inflammatory responses.

Emerging studies indicate that the responsiveness of AMPK signaling clearly declines with aging.

An increase of NAD+ levels followed by sirtuin activation is observed in situations of energy deficit, such as fasting (47), calorie restriction (CR) (47) or low glucose feeding (Fulco et al, 2008), and exercise (47,48).

On the contrary, multiple studies reported that high-fat high-sucrose (HFHS) feeding diminishes NAD+ content in liver (46,51), skeletal muscle (49), BAT (49), and white adipose tissue (WAT)

Conclusion: AMPK senses low energy levels and responds by signaling NAMPT to increase intracellular NAD+ concentrations (18)

CALORIE RESTRICTION DECREASES INFLAMMATION AND EXTENDS LIFESPAN

Calorie Restriction (CR) can extend longevity by 30–50% and remains the surest path to increased longevity and resilience to diseases of aging across many organisms, from yeast to monkeys and perhaps humans (32).

CR can lower the prevalence of age-related loss of function and multiple diseases, including tumors, cardiovascular disease, neurodegeneration, and protects against diabetes, cancer, cardiovascular disease, sarcopenia, and neurodegeneration of certain brain regions in rhesus monkeys (31).

Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as “inflammaging.” Inflammaging is a highly signifcant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis [r]

CR decreases inflammation, which is believed to be the reason it protect against multiple diseases and extends lifespan.

In non-obese, healthy adults, 25% CR decreases inflammation with no significant adverse effect.

These CR-induced changes suggest a shift toward a healthy phenotype, given the established role of these pro-inflammatory molecules as risk markers in the development of metabolic syndrome and age-related chronic diseases, in particular CVD, T2D and cancer(1).

Conclusion: Calorie Restriction of 25% or more has significant effect at combating disease and aging – But, is difficult to follow for humans

* Older mice and humans (70+) have not shown benefits from Calorie Restriction that younger people do

DIETARY RESTRICTION

The definition of dietary restriction has been expanded from an alternative description of caloric restriction to also encompass a broader scope of interventions, including :

  • Periodic fasting
  • Fast Mimicking diet
  • Intermittent Fasting
  • Time-Restricted Feeding

These relatively novel interventions are reported to have beneficial effects on overall health and in some cases longevity (34).

Both intermittent and periodic fasting can increase lifespan, even when there is little or no overall decrease in calorie intake (34).

When mice were given access to food for only 8–9 hours during the active phase of the day, metabolic diseases induced by a high-fat, high-fructose, and high-sucrose diet, were reduced without lowering caloric intake(34)

Ad lib feeding during the weekend did not interfere with the protective effects of time-restricted feeding(34)

Conclusion: Constant Calorie Restriction is not necessary. Short periods of deprivation provide the same benefits for health and life extension

GLUCONEOGENESIS

Although most of the brain can use ketones, there are portions that require glucose to function.

On a very-low-carb diet, the liver can also switch on gluconeogenesis, which means “making new glucose” from amino acids in protein, or from glycerol in triglycerides.

Gluconeogenesis increases metabolism to burn more calories (26, r).

Conclusion: On a very low-carb diet, up to 70% of the brain can be fueled by ketones. The rest can be fueled by glucose produced in the liver.

KETOGENIC DIET

The pie charts below show the typical nutrient breakdown of a low-fat Western diet, a low-carb diet and a typical ketogenic diet:

In fact, research shows that the ketogenic diet is far superior to the recommended low-fat diets for weight loss. (2, 14, 15, 16).

What’s more, you can lose weight without counting calories or tracking your food (16).

One study found that people on a ketogenic diet lost 2.2 times more weight than those on a calorie-restricted low-fat diet. Triglyceride and HDL cholesterol levels also improved (17).

Another study found that participants on the ketogenic diet lost 3 times more weight than those on the Diabetes UK’s recommended diet (r).

A ketogenic diet also lowers risk for many diseases (8, r, r, 11, r, 13).

They are now being studied as a treatment for a wide variety of conditions (r):

  • Heart disease. Reducing carbs to achieve ketosis may improve heart disease risk factors like blood triglycerides, total cholesterol and HDL cholesterol (r, r).
  • Type 2 diabetes. The diet may improve insulin sensitivity by up to 75%, and some diabetics are able to reduce or even stop diabetes medication (r, r).
  • Metabolic syndrome. Ketogenic diets can improve all major symptoms of metabolic syndrome, including high triglycerides, excess belly fat and elevated blood pressure (r).
  • Alzheimer’s disease. A ketogenic diet may have benefits for patients with Alzheimer’s disease (r).
  • Cancer. Some studies suggest that ketogenic diets may aid in cancer therapy, possibly by helping to “starve” cancer cells of glucose (r, r).
  • Parkinson’s disease. A small study found that symptoms of Parkinson’s disease improved after 28 days on a ketogenic diet (r).
  • Acne. There is some evidence that this diet may reduce the severity and progression of acne (r).

Conclusion: Studies show that ketogenic diets lead to more weight loss than low-fat diets, and help with a number of chronic diseases, including metabolic syndrome, type 2 diabetes and Alzheimer’s.

FAT FASTING

A report by the US Institute of Medicine’s Food and Nutrition Board states: “The lower limit of dietary carbohydrates compatible with life apparently is zero, provided that adequate amounts of protein and fat are consumed.”

In one study, a group of volunteers fasted for 84 hours (3.5 days), or received a lipid infusion such that they got all the calories they needed.

The researchers found that there were no differences in “plasma glucose, free fatty acids, ketone bodies, insulin, and epinephrine concentrations” between fasting and non-fasting conditions (30)

The authors conclude, “These results demonstrate that restriction of dietary carbohydrate, not the general absence of energy intake itself, is responsible for initiating the metabolic response to short-term fasting.” (30)

Conclusion: Calorie Restriction is NOT NECESSARY – Carbohydrate restriction provides the benefits

DON’T BE AFRAID OF “GOOD FAT”

For those that have a fat phobia, here’s 3 recent studies that may open your eyes a little.

Study 1: Compared three different diets for weight loss: Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet.

The low-fat diet was calorically restricted, with a target 1800 calories a day for men, 1500 for women. It was 30% of calories from fat, and “participants were counseled to consume low-fat grains, vegetables, fruits, and legumes and to limit their consumption of additional fats, sweets, and high-fat snacks”.

The Mediterranean diet’s target calorie intake was the same as for the low-fat, but with a goal of 35% calories from fat, “the main sources of added fat were 30 to 45 g of olive oil and a handful of nuts (five to seven nuts, that’s it).

Thelow-carbohydrate diet was not restricted in calories; it was all you can eat. It provided “20 g of carbohydrates per day for the 2-month induction phase…, with a gradual increase to a maximum of 120 g per day to maintain the weight loss.

Typically, high quality garcinia cambogia supplements cost $25 to $50 per bottle, depending on the amount of garcinia cambogia in each capsule, and the number of capsules in the bottle.

The intakes of total calories, protein, and fat were not limited.

The study lasted for 2 years; all participants were either overweight (BMI ≥27), or with diabetes or coronary heart disease.

This was was a high-fat diet, with 95% fat, 5% protein, and 0% carbohydrate. When animals were switched to this diet they lost weight, lower glucose and insulin, and higher AMPK activity.

Study 3: Heres’ an interesting new study on the effects of keto diet on human muscles. The effects of ketogenic dieting on skeletal muscle and fat mass. One reason why it’s interesting is that the men in the study were already resistance-trained.

Twenty-six college aged resistance trained men volunteered to participate in this study and were divided into either:

  • VLCKD (5 % CHO, 75 % Fat, 20 % Protein)
  • traditional western diet (55 % CHO, 25 % fat, 20 % protein)

All subjects participated in a periodized resistance-training program three times per week

The ketogenic diet group gained 4.3 kg lean mass (muscle) compared to only 2.2 kg for the traditional diet group

The ketogenic group lost 2.2 kg of fat, compared to 1.5 kg in the traditional group.

Here’s some more articles that dispel the myths about Carbohydrates vs Fats in the human diet.

KETONE BODY β-hydroxybutyrate (BHB) THE KEY TO LIFE EXTENSION PROPERTIES OF CALORIC RESTRICTION

When the blood-glucose level drops the liver generates glucose by breaking down glycogen. If glucose levels drop too much, the liver synthesizes ketone bodies as a sort of back up fuel source for use by other organs (4).

So, levels of ketone bodies are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet (5).

Studies in cells (r), animals (r), and patients (r, r) suggest that it may be useful in common neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases, as well as in insulin-resistant states, such as trauma, heart failure, and diabetes (r).

Many aging-induced changes, such as the incidence of malignancies in mice (10), the increases in blood glucose and insulin caused by insulin resistance (11), and the muscular weakness have been shown to be decreased by the metabolism of ketone bodies (12).

BHB INHIBITS INFLAMMATION

β-hydroxybutyrate (BHB) is one such ketone body of particular interest as it has unique properties in reducing inflammation (5).

BHB is not used solely as a energy source, but also acts as a signal to regulate metabolism when energy sources are low (5).

Due to this special role, only BHB suppresses activation of the NLRP3 inflammasome, a key driver of systemic inflammation.

Other ketone bodies such asAcAc, butyrate and acetate do not have a similar effect on inflammation (5).

The ketone metabolite BHB blocks NLRP3 inflammasome-mediated inflammatory disease and mimics the life span extending properties of caloric restriction

BHB AND NAD+

A 2016 study found β-hydroxybutyrate significantly increased the phosphorylation of AMPK (16).

AMPK activation is the key signal that drives increased NAMPT, which is the rate limiting factor in the bodies constant recycling of NAD+ (r).

Metabolism of one BHB molecule require 2 molecules of NAD+ instead of the 4 molecules required in normal glucose metabolism, thereby preserving the cytoplasmic NAD+ pool (7).

  • Inhibits inflammation which is a key consumer of NAD+ as we age
  • Activates AMPK which drives endogenous production of NAMPT and NAD+
  • Uses 50% less NAD+ in the production of ATP for basic cellular energy

In humans, serum levels of BHB are usually in the low micromolar range but begin to rise to a few hundred micromolar after 12–16 h of fasting, reaching 1–2 mM after 2 days of fasting (r) and 6–8 mM with prolonged starvation (r).

Similarly, serum levels of BHB can reach 1–2 mM after 90 min of intense exercise (r). Consistent levels above 2 mM are also reached with a ketogenic diet that is almost devoid of carbohydrates (r).

BHB, NAD+, INFLAMMATION, DISEASE, AGING – PUTTING IT ALL TOGETHER

Three new independently conducted studies show that the increased BHB produced in a ketogenic diet improved the NAD+/NADH ratio which decreases expression of the pro-inflammatory NF-κB gene, resulting in:

  • weight loss
  • improved memory
  • improved physical strength
  • 13-percent increase in median life span

One study – led by Drs. Eric Verdin and John Newman, looked at the effect of the keto diet on aging mice.

Remarkably, the older mice on the ketogenic diet had a better memory than the younger mice – months after they had gone off a ketogenic diet.

Dr. Verdin, says this is the first study to demonstrate how BHB improves memory and lifespan. “This opens up a new field in aging research. We think the health benefits of BHB may go beyond memory and could affect tissues and organ systems”

The second study – led by Dr. Jon Ramsey, looked at adult mice and had similar findings about the impact of the keto diet, with the addition that it may also improve strength and coordination.

The second study not only showed the improvement from a cyclical keto diet, but were able to prove that BHB was the mechanism behind it.

The third study by Yiguo Shen and Raymond Swanson found the BHB produced in a keto diet improved the NAD+/NADH ratio to block brain inflammation following stroke and brain trauma.

The researchers used a small molecule called 2-deoxyglucose, or 2DG, to block glucose metabolism and produce a ketogenic state in rats. They found 2DG could mimic a keto diet, increasing BHB and NAD+ production, and bring inflammation levels down to normal levels.

MCT stands for medium-chain triglycerides, which are fats found in foods like coconut oil. They are metabolized differently than the long-chain triglycerides (LCT) found in most other foods.

Because of the shorter chain length, MCTs go straight to the liver where they are used as an instant energy source or turned into ketones.

This makes MCT oil an ideal energy source for those looking to cut down on carbs and maximize BHB ketone production

MCT oil aids weight loss by:

  • Fat Storage: Given that MCTs are absorbed and used more rapidly than LCTs, they are less likely to be stored as body fat (10).
  • Burn Calories: Studies in animals and humans show that MCTs (mainly C8 and C10) may increase the body’s ability to burn fat and calories (12, 13, 14, 15, 16, 17, 18).
  • Greater Fat Loss: One study found that an MCT-rich diet caused greater fat burning and fat loss than a diet higher in LCTs. However, these effects may disappear after 2–3 weeks once the body has adapted (18).

In addition to weight loss, the increased production of ketones and decreased good sugar levels make MCT oil a increasingly popular therapy for disease control.

One study in children found that the MCT diet was comparable in effectiveness to the classic ketogenic diet in controlling seizures (23).

In one study of 152 people with Alzheimer’s disease, those who received an MCT supplement for 90 days had much higher ketone levels and a significant improvement in brain function compared to a control group (34).

One of the great things about MCT oil is that it has virtually no taste or smell, and doesn’t need to be refrigerated. So it is easy to add to protein shakes or bulletproof coffee.

Another great thing about MCT oil is the price. This 32 ounce bottle at Amazon is around $24. That’s nearly 9,000 calories in the bottle, which is the calories most people consume in 4-5 days. So per calorie, its less $ than McDonalds!

Conclusion: MCT’s are quickly converted to Glucose for energy if needed, or converted to Ketones. They can increase BHB production even without dieting

NMN GREATLY INCREASES FAT METABOLISM

Administration of NMN improves mitochondrial fatty acid oxidation (33)

NMN-administered mice switched their main energy source from glucose to fatty acids (23)

EXERCISE INCREASES LIFESPAN

The best way to stay young really might be to keep moving. Research has shown physical activity can reduce inflammation in your body and improve heart health—both important for staying young beyond your years.

Aging results in chronic low grade inflammation that is associated with increased risk for disease, poor physical functioning and mortality. Strategies that reduce age-related inflammation improve the quality of life in older adults (1).

Regular exercise is recommended for older people for a variety of reasons including increasing muscle mass and reducing risk for chronic diseases of the heart and metabolic systems (2).

This recent study found that 4 hours of running per week increased average lifespan by 3 years. Surprisingly, time spent running added more time that it took to run, with each hour running adding 7 hours on average.

HIIT IS BETTER

HIIT involves short bursts of intense exercise alternated with low-intensity recovery periods. Interestingly, it is perhaps the most time-efficient way to exercise (4, 5).

Typically, a HIIT workout will range from 10 to 30 minutes in duration (4).

Despite how short the workout is, it can produce health benefits similar to twice as much moderate-intensity exercise (6, 7).

This would be considered one “round” or “repetition” of HIIT, and you would typically complete 4 to 6 repetitions in one workout (4).

Regardless of how it is implemented, high-intensity intervals should involve short periods of vigorous exercise that make your heart rate speed up (4, 8).

This recently published study compares HIIT with resistance training and combined weights/cardio training. It found HIIT to be far more effective, particularly for older humans.

HIIT continues to burn calories long after you finish exercising because your muscles need to use more energy to recover after exercise (68,69).

In fact, research has shown that HIIT can burn up to 190 calories over 14 hours after exercising (69).

Research also shows that HIIT can help your body build and preserve muscle mass with age (70).

In some cases, the high-intensity regimen actually seemed to reverse the age-related decline in both mitochondrial function and muscle-building proteins.

  • High intensity interval training (HIIT), in particular sprint interval training (SIT), has been shown to promote mitochondrial biogenesis
  • SIT is usually performed as very short sprints (20-30 s) at maximal intensity (“all out” effort) repeated 4-8 times.
  • As few as 4-6 sprints have been shown to increase mitochondrial biogenesis to a similar extent as long duration cycling (90-120 min at 65% of VO2max)
  • research shows that it is more beneficial to undertake most training in a “low” glycogen state (Hansen et al., 2005) .

EXERCISE AND CR INCREASE NAD+ PRODUCTION

It’s clear that the same things that help fight inflammation also increase NAD+.

AMPK is the reason why. CR and exercise active AMPK, which stimulates NAMPT to metabolize more NAD + (20, 54)

Exercise, especially HIIT, activates the enzyme AMPK to increase your NAD+ levels, stimulate glucose uptake ad mitochondrial biiogenesis (31, 55)

Exercise while fasting is even more effective at cranking up AMPK to elevate your NAD+ levels (r). Exercise while fasting, or continue to exercise after you “hit your wall” (55)

“Athletes have a 2-fold higher levels of NAMPT in their skeletal muscle compared with sedentary adults” (38

Exercise, especially HIIT, activates the enzyme AMPK to increase your NAD+ levels, stimulate glucose uptake and mitochondrial biiogenesis (31)

Exercise while fasting is even more effective at cranking up AMPK to elevate your NAD+ levels (r).

Conclusion: HIIT 2-3 times per week while in low blood glucose state is ideal for Activating AMPK and boosting NAD+

SUPPLEMENTS TO INCREASE NAD+

Studies show that high levels of NAD+ result in stronger, healthier cells and mitochondrial function. (r)

More importantly, their analysis revealed that mitochondrial dysfunction is reversible with NAD+ supplementation, enabling the life and health of cells to be prolonged at the molecular level. (r)

NAD+ cannot be taken as oral supplements because it does not survive the digestive system long enough to enter your cells (25).

However, researchers have found that the molecules our bodies use to make NAD+ can be taken as supplements and DO make their way through the digestive system where they are processed (mostly) by the liver and DO raise NAD+ levels in the blood and organs.

These NAD+ precursors have been tested in mice and humans to evaluate their effectiveness at elevating NAD+ levels and treating various disease conditions. The NAD+ precursors are (25):

NAM, Niacin, and Tryptophan have been shown to alleviate symptoms in a wide variety of disease, but have some drawbacks such as intense flushing (niacin).

The landmark 2013 study by Dr. Sinclair demonstrated that supplementation with NMN increased levels of NAD+ and reversed age related degeneration in mice, giving older mice the muscle capacity, endurance and metabolism of much younger mice – the “equivalent of a human 60 year old becoming more like a 20 year old” (24).

That study really lit a fire to research in the role NAD+ plays in regulating our metabolism and aging, with dozens of studies already completed and even more underway.

A later study by Dr Sinclair published in 2016 looked at the effects on health of long term (12 months) administration of NMN on mice (23). The following quotes are from that study:

NMN effectively mitigates age-associated physiological decline in mice

NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies

These effects of NMN highlight the preventive and therapeutic potential of NAD + intermediates as effective anti-aging interventions in humans

NR was discovered in 2004 by Dr Charles Brenner, and is used in his experiments. Although NR is unstable by itself, Dartmouth University has patented production methods that combine it with Chloride which makes it stable.

Chromadex has licensed this technology and has been selling NR commercially since 2014 under the brand name “Niagen”.

They controlled the market for NR until just recently, when Elysium Health has begun to market their own version of NR in their Basis product.

Dr. Brenner has been instrumental in leading research into the health benefits of NAD+ supplementation using NR, and led the first human studies of NR published in 2016. He is the chief science officer for Chromadex, and founder of the company that markets Tru Niagen, the official brand favored by Chromadex.

“Not every cell is capable of converting each NAD+ precursor to NAD+ at all times…the precursors are differentially utilized in the gut, brain, blood, and organs” (R).

AMPK and NAMPT activators

With the realization of the profound impact that boosting NAD+ levels has on health and lifespan, researchers are now testing thousands of natural products that may stimulate AMPK (60).

You might notice that many the SAME supplements that have the greatest positive impact on health ALSO ACTIVATE AMPK.

This is further confirmation that the AMPK-NAD+ pathway is a key determinant of healthy aging (60)

  • Berberine has been shown to lower blood sugar levels as much as the leading prescription drug Metformin. They may be equally effective at lowering inflammation thru their effect on blood sugar levels, but Metformin has been shown to lower NAD+ levels (r), so I would definately recommend Berberine.
  • Chlorogenic Acid (CGA), one of the active ingredients in Green Coffee beans, has prove to be a strong activator of AMPK (58). CGA was also show to increase metabolism, lower blood sugar levels, and decrease risk of diabetes (59).
  • EGCG – EGCG activates AMPK, enhancing insulin signaling pathway by membrane translocation and phosphorylation of IRS-1, improving insulin sensitivity and secretion (60)
  • Curcumin
  • Leucine – “Addition of leucine to HFD restored NAMPT expression.