Recommended use of garcinia cambogia

Recommended use of garcinia cambogia
Traces of Calcium According to 2008 research published in the British Journal of Nutrition (BJN), decent calcium intake may spur weight loss especially in obese people whose diet is calcium deficient.

Recommended daily dosage of Garcinia Cambogia Extract

Every supplement out there, including Garcinia cambogia has an important factor: the proper dosing and the right timing. It plays a crucial part in your diet. To be able to understand it completely, you should know how Garcinia works once it is in your body.

For many people garcinia cambogia with colon cleanse works much better than the simple garcinia, but if you are looking for the simple formula dosage, read on.

Basically, it’s not that complicated: You take the pill, it dissolves in your body and starts working. However, timing is very important! So lets look at that first.

What is the proper way to take Garcinia Cambogia?

You probably knew this already, but it depends on WHICH BRAND you are taking. Since I am only recommending two brands, I will write about those: Garcinia Cambogia 1000mg and the Garcinia Cambogia Pure.

The proper timing to take Garcinia Cambogia is one pill approximately 30 minutes to 60 minutes before meal. If you are using Garcinia cambogia 1000mg then you should take 2 pills a day (one in the morning and one in the evening). And if you are taking the Garcinia PURE better then you should know that this one should be taken 3 times a day! This is why it has more pills in one bottle.

This table breaks it for you better:

with Potassium and Calcium

Dosage: 1 pill 30-60 minutes before meal. Take 2 pills a day.

Dosage: 1 pill 30-60 minutes before meal. Take 3 pills a day.

But in any case, make sure you are taking it 30-60min BEFORE you start eating.

This part is important, because Garcinia Extract is water-soluble (easily dissolves in water) and you want it to be dissolved fast and to start working. It’s a pretty fast process in your body, and works better if you have not eaten for couple of hours.

After you take Garcinia, it is important to wait at least 30 minutes before your meal, in order to ensure it has dissolved completely, and the Serotonin levels have risen enough.

This is the ‘by the book’ method, but if you don’t follow the rules strictly, you still shouldn’t be alarmed. Your body will eventually process it and you will feel decrease in your appetite.

Hey, I even heard stories about people taking Garcinia 1 hour after their meal, because it helps them to stop snacking between meals, stops their emotional eating, and that is a good thing!

Now that you know how to do it, let’s look at the “how much” part of it!

What is the recommended daily dosage of Garcinia Cambogia Extract?

If you are using any other brand of this slimming pill, then know this:

The daily dosage of Garcinia varies depending on your current weight and metabolism, but it is always safe to go with the standard dose. The standard recommended dosage is 500-1500 mg of 50% HCA per day, but this could vary a little bit. It is totally safe, for example, if you take 2 pills of 1000 mg Garcinia a day.

Studies have shown that lower dosage – for example if you are taking only one pill a day – might help as appetite suppressants, while larger dosage – taking one pill before each meal – helps with people who are in weight loss programs.

People with high energy levels and activity (people who exercise or eat a lot of carbon-hydrates) might also need more. But in any case if you plan to increase the dose, I would encourage you to ask for your doctors opinion first.

Keep in mind, that after approximately 12 weeks (3 months) of taking the Supplement, it is good to have a break for a week or two. After that, you can begin your cycle again with total confidence.

Should I change my everyday diet?

Unless you are unsatisfied with your current diet, don’t change it. If it is a low-carb diet, you might need more time to have the same benefit, but there is no real proof that it wouldn’t work for you. Generally speaking, there is no point in changing your diet drastically just because of Garcinia Cambogia.

Since you are taking the Garcinia Extract supplement before your meals, and you know how it works, what you should notice is a decrease in appetite. This is the normal reaction and this is how you start loosing weight. You can also focus on preparing or ordering less food, and in this way avoid any temptation of overeating.

And after couple of weeks the benefits of weight-loss should already be visible. Remember, being of ideal weight is not just a matter of aesthetics, it is vital that your inner organs are not covered with fat but rather work normally the way they are intended to. Your body will feel better, you will feel better and be loaded with happiness and energy.

Is there a possibility that Garcinia Cambogia doesn’t work?

If you are currently on a low-carb diet, then Garcinia Extract might take a little more time to show all its benefits, but it should eventually work without problems. This happens because HCA works in a way that it stops creation of fatty cells from carbohydrates. If your carbohydrates intake is less than usual, the time-frame of your diet could be expanded a little bit.

What’s the most important is not to lose faith immediately, rather be patient and keep on with the supplement. You can also check the following post I wrote: what to do if Garcinia Cambogia doesn’t work.

If you are unsure what contains carbs, here is a short list of food that is known to contain a lot:

Many other things of course, but these food are on the very top of the list.

You should also know that soft drinks are high in carbohydrates, the amount of sugar in any soft drink is very high on the list.

Carbohydrates are very popular since they are an immediate source of energy. However taking more carbs into your body then needed easily leads to extra weight: it is “stored” in your body in form of fat.

Bottom line. If you don’t eat a lot of carbs, you still can benefit from this supplement.

This natural diet supplement promises to wield the many benefits of the Malabar tamarind to help you lose weight safely and effectively, making shedding off the pounds a lot simpler and less frustrating.

It just might take a little longer.

If you would like to implement Garcinia Cambogia in your diet, make sure you check out my buying guide called where to buy garcinia cambogia extract.

In this post I will explain how you can SAVE A LOT of money on your purchase .

There is no need to wait anymore. In 3 months time, you will wish you would have started today!

Click the link below, fill in the secure order (it’s very easy) and start your weight loss journey today!

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol.

Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF.

Also a childhood memory for me, and I could pin down what it reminds me of: scented stationery products for girls from the 80s (correspondence kits with pretty pink envelopes and writing pads with shabby chic pictures of angels on them).

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The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans.

Simply Garcinia scam review Ever since its first appearance on the Dr Oz Show you cannot browse the internet without coming across various adverts for Garcinia Cambogia supplements.

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The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation. One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet.

So instead of counting calories and making sure you get enough out of each minute of exercise per day, you can use this product as an assistant to your weight loss.

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17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

37. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-) hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods . 2008;18(5):443-451.

38. Kaur G, Kulkarni SK. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Eur J Nutr . 2001;40(3):127-133.

39. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis . 2007;39(10):953-955.

40. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. [Published correction appears in: Am J Med Sci . 2004;328(2):129.] Am J Med Sci . 2004;327(6):356-357.

41. Ferris DJ. Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report. ASHP Midyear Clinical Meeting . 38(DEC): p P-404(D). 2003.

42. Pittler MH, Schmidt K, Ernst E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes Rev . 2005;6(2):93-111.

43. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci . 2009;54(2):406-408.

44. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol . 2009;15(14):1786-1787.

45. Anno T, Oono H, Tamura K. Improvement of testicular toxicity in F/344DuCrj male rats fed Ca-type Garcinia cambogia extract by zinc supplemented diets. Nippon Shokuhin Kagaku Gakkaishi . 2005;12(3):121-127.

46. Shara M, Ohia SE, Yasmin T, et al. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days.

Interaction between warfarin and Garcinia cambogia (Fat Burner); a case report.

Mol Cell Biochem . 2003;254(1-2):339-346.

47. Burdock G, Soni M, Bagchi M, Bagchi D. Garcinia cambogia toxicity is misleading. [Published correction appears in: Food Chem Toxicol . 2007;45(3):515.] Food Chem Toxicol . 2005;43(11):1683-1684; author reply 1685-1686.

48. Min B, McBride BF, Kardas MJ, et al. Electrocardiographic effects of an ephedra-free, multicomponent weight-loss supplement in healthy volunteers. Pharmacotherapy . 2005;25(5):654-659.

49. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia . 2008;79(4):255-261.

Copyright © 2009 Wolters Kluwer Health

Recommended use of garcinia cambogia

Don't Buy Garcinia Cambogia Until You Know You Are Getting One That Works

When you want to lose weight, the safest way to go is the natural way. However, results can sometimes take too long that people would rather turn to supplements made with harsh chemicals and even surgery to get the body that they want overnight. Indeed, losing weight can be such a challenge, especially if you have a very busy lifestyle.

With scientists and the general media raving, one of the most popular NATURAL weight loss solutions today is garcinia cambogia extract dietary supplements. An exciting new breakthrough in the weight loss industry, it is considered to be mother nature's simple answer to losing weight.

One of the recommended brands of garcinia cambogia is Garcinia Cambogia Extra . Made with 100% natural and 100% pure ingredients, Garcinia Cambogia Extra gives you fast and effective results even WITHOUT DIET or EXERCISE!! Making you lose weight in 3 ways, Garcinia Cambogia Extra is the perfect solution to a healthier and slimmer body.

Overview of Garcinia Cambogia Extra

Garcinia Cambogia Extra manufactured in an FDA registered, cGMP certified laboratory, ensuring you that they are up to par with the high standards in manufacturing. Safe and effective, Garcinia Cambogia Extra promises results AND delivers.

Unlike other garcinia cambogia extract products that are filled with other ingredients, Garcinia Cambogia Extract is 100% PURE – which means it has NO fillers, NO binders, and NO artificial chemicals! These all-natural veggie capsules meet every criteria of an effective and fast-acting garcinia cambogia product:

  • Contains 60% HCA (Hydroxycitric Acid)- the needed percentage that makes garcinia cambogia effective in weight loss
  • Its recommended dose is 500mg before each meal – the needed dose is from 1500-3000mg ever day
  • Garcinia Cambogia Extra is made of 100% pure HCA and 100% natural ingredients with NO calcium, NO binders, NO fillers, and NO additives
  • All of their products are made in FDA registered laboratories and cGMP certified labs – assuring you that each bottle meets the standards of quality

Producing truly effective and pure garcinia cambogia extract capsules, Garcinia Cambogia Extra promises 100% Satisfaction and 30-Days Money Back Guarantee!

How Does Garcinia Cambogia Extra Work?

Garcinia Cambogia is a tropical natural fruit that is dubbed as a superfruit. The extract in the capsules is taken from the rind, where there are great amounts of HCA (Hydroxycitric Acid) – the key ingredient to making you lose weight. It works in a triple-action powerful combination:

1. Inhibits your appetite by telling your brain that you are already full while also making your feel fuller longer.

2. Blocks fat from being formed in the body by preventing the citrate lyase from turning your carbohydrates into fat. Instead it is turned into energy.

3. Boosts serotonin levels in your brain, which makes you feel better by improving your moods and regulating sleep – decreasing your need for emotional eating.

This triple-action formula is the powerful combination that gives garcinia cambogia its effective weight loss properties.

Garcinia Cambogia Extra Benefits

Aside from the 3 main ways that Garcinia Cambogia Extra help you lose weight, here are its other great benefits:

  • Lowers the level of bad cholesterol in your body
  • Manages the stress hormone cortisol, helping emotional eaters from food cravings
  • Attacks your belly fat

Moves toward glycogen – which helps you burn more fat

Decreases your urge to consume more calories

Because Garcinia Cambogia Extra is made with an all-natural fruit, there are NO SIDE EFFECTS!

You get to lose weight and body fat even WITHOUT DIET NOR EXERCISE! Compared to others who did not take garcinia cambogia, users lost 2-3 times more weight – and that's without changing a thing to their lifestyle! Just the perfect solution for busy bodies.

Ordering Garcinia Cambogia Extra

Because of the popularity of the product, Garcinia Cambogia Extra is struggling to keep their supply in stock. You can visit their safe and secure website to get your hands on any of their product packages. Currently, there are 3 to choose from:

  • Order 1 bottle (1 Month Supply) for $49.95! Lose up to 10 lbs
  • Order 2 bottles and get 1 bottle FREE($33.00 each, $99.95 total)! Lose up to 20 lbs
  • Garcinia Cambogia Extra's BEST SELLING PACKAGE. Order 3 bottles and get 2 bottles FREE ($29.00 each, $149.95 total)! Lose up to 30 lbs

ALL ORDERS come with 30-DAY MONEY BACK GUARANTEE! So, feel confident that you will lose weight, or your money back!