Side effects of garcinia extreme

Side effects of garcinia extreme
I will wait to see at the end of the month.” The Bottom Line on Super Citrimax So, our final thoughts include if Super Citrimax works for weight-loss.

Side effects of garcinia extreme

Ultavive Garcinia is an essential and energetic strategy for naturally losing the fat. You can without a lot of an extend swallow it as it is open in container frame. It is a normal weight upkeep thing. You can in like manner name it as the weight diminishment or craving control supplement. It has various names since it is prepared for performing unmistakable limits in your body. Probably, you do practices in the rec focus to shed many pounds of weight. Clearly, it works yet bit by bit. To help up to the results, this weight lessening supplement is inferred for you. Therefore, shed your weight with the right use of this supplement constantly.

It is gotten from the pumpkin formed characteristic item, known as the Ultavive Garcinia. It is absolutely a safe and a trademark respond in due order regarding lessening your general weight. It includes the focus of Ultavive Garcinia regular item, containing Ultavive Garcinia It is a 100 percent safe thing, which has been shown practical for some individuals wherever all through the world.

About Ultavive Garcinia !

It is fundamental to understand that only one out of every odd one of the supplements made of Ultavive Garcinia is made an equal. Ultavive Garcinia has shown practical for people of different ages. It is a dietary supplement, which cases to consolidate the best weight lessening condition. This supplement controls your desire superiorly. Additionally, it causes you in devouring with seething warmth the fat cells and shielding new oily cells from being made.

Ultavive Garcinia Free Trial :-

I acknowledged that you need to know more this striking supplement. Discover more in this sensible diagram of this thing. All confirmations depend upon sharp research and extensive examination of the thing just to give solid wellspring of general thing data to all.

Why Ultavive Garcinia?

From the essential day, it starts endeavoring to smother the craving levels by making it controlled. After couple of measurements, it reduces the fat cells in the body. The critical component of this supplement is, HCA is responsible for keeping the difference in starches into fat cells. It diminishes the fat cells by transforming them into imperativeness. You can find the information about this association on the web. Along these lines, it begins to diminish the weight by influencing it to culminate without side effects. Ultavive Garcinia is the best pill in which you can contribute and dispose of your fat issues quicker.

As Ultavive Garcinia is a trademark count calories pill, it typically attempts to lose your weight by murdering the extra fat. It furthermore expels the extra waste substances from your body. It just keeps the essential vitamins and minerals in your body, which are relied upon to perform various limits. The fat is melted like a solidified yogurt with its standard use. It endeavors to control your enthusiastic dietary examples with the objective that you may feel full. It keeps the eating that you do again and again. Thusly, get prepared yourself to put in a demand for this eating regimen pill to get its leeway for your body.

  1. On the off chance that you move with all the proposed bearings by the authorities, it will have the ability to offer the underneath recorded points of interest
  2. Removing of the waste things
  3. Diminishment of fat, especially from stomach and thighs
  4. Legitimate control on emoting dietary examples
  5. No responses till date
  6. Furnishes with the best results quickly than exercises or thinning down
  7. A risk free and sound response for shed pounds
  8. Comprises of simply the most secure parts

Ultavive Garcinia recommended by specialists

As a result of its positive results, a couple of masters and therapeutic prosperity experts have urged it to be used by others. They have been assumed that Ultavive Garcinia is one of the endorsed and trusted formulas to decrease the body weight and fat without any side effects. As showed by the examinations being made, it has shown that it can reduce your muscle to fat proportion proportions safely and really. Furthermore, it gives you the aggregate satisfaction guarantees.

It is basic to know whether an eating routine pill is secured to use or not. It doesn’t contain any ruinous substance to convey any response to your body. There is nothing to worry over its security. You can go for reviews and tributes available online to guarantee the prosperity of this supplement. It is best urged to utilize this eating regimen pill after the exchange of the experts. Likewise, there are rules open on the container in a printed shape; you need to tail them to use it.

Ultavive Ultavive Garcinia additional tips

By following a strong lifestyle, it will contribute more towards your objectives related to weight lessening. No ifs ands or buts, you can express that getting uncovered into sound and honest to goodness eating regimens can enhance the results than run of the mill. Additionally, you can drink an a lot of water, delightful substances and significantly more to help up the results. Solid and new supports are fundamental to carry with this supplement. It is likewise major to drink and a great deal of water. Thusly, you can gain perfect results, which may continue going for a broad between time of time.

  • Diminishes your weight ideally
  • Free from indications
  • Get a thin and trim body appearance
  • Keeps the fat cell creation
  • Controls your yearning by wearing down the excited dietary examples
  • Most secure piece are joined into it

For what reason do I prescribe Ultavive Garcinia?

Clearly, it is anticipated to take. It is a result of the way that each one of the segments is protected and normal, which is available in it. Furthermore, there is no chance to get of any side effect. I have gone for this eating routine pill before long.

Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance.

According to my opinion, I have never felt any side effect with its typical use. I propose you in any case it. However in the meantime, in the event that you have any inquiries concerning the prosperity of this supplement, you can investigate about it on the web. There are different reviews open on the web, which reveal an incredible arrangement about the security and focal points of this item.

Genuine individuals genuine outcomes

Alia says, “I have been encountering overweight issues for quite a while. When I started Ultavive Garcinia, it has wiped out my muscle to fat remainders just and securely.”

Mary says, ‘I expected to wear my appealing dresses, yet I can’t on the grounds that I was fat and these dresses influence me to look terrible. Ultavive Garcinia weight reduction eat less carbs pill has changed the way, I have decreased my weight.”

Where to purchase Ultavive Garcinia?

Ultavive Garcinia can be asked for from its official site. Plan to present a demand for it now! Likewise search for its free trial and different offers on the official site. Click here

Nutralu Garcinia – Read Price,Side Effects,Benefits & Free Trial

Nutralu Garcinia was tended to with the word fatso among my companions as opposed to being called by my name. Now and then it cleared out me annoyed as I had a feeling that I was left with this character as it were. I needed to change myself physically to procure some regard according to individuals around me. I admitted my emotions to by best pal and she acquainted me with Nutralu Garcinia. Presently I claim a provocative and breathtaking body due to this supplement. To investigate how it helped me, keep perusing…

Ingredients of Nutralu Garcinia :-

The mystery behind the viability of this supplement is its arrangement. It is produced from the concentrates of Garcinia Cambogia natural product, which is stacked with Hydroxycitric corrosive (HCA. This natural product is generally developed in Southeast Asia and India and has been utilized as a part of an assortment of cooking styles.

How Does Nutralu Garcinia Work?

  • This supplement is sustained with a perfect measure of HCA, which is accepted to encourage weight reduction by acting in following ways:
  • It stops the procedure of fat arrangement by deactivating the citrate lyase compound, which is considered in charge of the change of unused starches into triglycerides.
  • It quickens the speed of digestion and drives the put away fat to be devoured as a fuel all the while, prompting the age of upgraded vitality.
  • It goes about as a hunger silencer and in this manner keeps a beware of the admission of additional calories.

Is Nutralu Garcinia Effective?

In the event that I need to remark on its adequacy, there is just a single thing I could state that this supplement is far superior powerful and sheltered when contrasted with those I had attempted before. Its viability has likewise been assessed amid clinical trials. Indeed, even specialists and doctors bolster its use, so you yourself can envision how successful it could be.

How Fast Does Nutralu Garcinia Work?

In the event that you are thinking about how quick this supplement could function, at that point you will be astounded to hear this astonishing recipe begins conveying you with observable advantages inside half a month as it were. Nonetheless, the correct time shifts with various people contingent upon the way of life they take after.

  • Not appropriate for the assortment of minors
  • Can not be bought disconnected
  • Results may fluctuate with people
  • Has not been affirmed by FDA

This is an extreme arrangement, which is defined with a logical way to deal with help in overseeing weight. It has altered the field of weight reduction by offering a basic strategy for liquefying ceaselessly lumps and flabs without the need of investing hours in the rec center or keeping yourself starving. This supplement encourages you in getting a thin and hot body by checking the procedure of fat arrangement alongside influencing you to feel less eager. It smothers the hunger and inspires the mind-set so you would not crave swallowing exorbitant calories down.

Benefits of Nutralu Garcinia :-

I began utilizing it around 7 months back when my weight came to up to 140 lbs. Amid beginning 2 weeks I didn’t watch any critical change, however from the third week just, I began feeling not so much ravenous but rather more fiery. I proceeded with its utilization and following a month when I examined myself on the size of a weight machine, it was indicating 135 lbs. With its general use, I have lost as much as 35 lbs in only 4 months. Despite everything I utilize it and feel in paradise.

Where to Buy Nutralu Garcinia?

It is exceptionally easy to get hands alone container of Nutralu Garcinia. It is accessible on its official site, which you have to visit and put in your request along these lines giving the required data. Likewise profit the advantage of the trial pack, which is set aside a few minutes clients as it were.

Garcinia (hydroxycitric acid)

Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)

Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )

The medical literature primarily documents weight loss and lipid-lowering activity for the plant. However, trials supporting its use are limited.

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day).

As a more powerful version of these fibers, it binds fat molecules in gut, preventing them from being absorbed by body.

In addition, we offer a 100% money back guarantee and same day shipping.

The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

  • Overview
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Contraindications

Avoid use if there is a known allergy or hypersensitivity to any components of G. cambogia .

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

The herb has documented drug interactions.

Adverse Reactions

At least 15 clinical studies involving approximately 900 patients document very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dosage of 1.5 g/day of HCA. In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur.

The genus Garcinia is mainly distributed in tropical regions and includes approximately 200 species. G. cambogia belongs to the family Guttiferae and is found in India, Malaysia, and Africa. G. cambogia is commonly found in evergreen or semievergreen forests of southwest India, where 36 other species have been documented. 1 , 2 The plant species has variability in its branching pattern, fruit color, shape, and size. 1 The tree is small-to-medium in size with drooping branches. The leaves are dark green and glossy, oval-shaped with a narrow end, 5 to 12 cm in length, and 2 to 7 cm around. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. 2

Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower pH and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. 2 , 3 , 4

HCA is the primary medicinal component contained in the fruit rinds of G. cambogia . 5 HCA is present as up to 30% by weight in the pericarp of G. cambogia fruit. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. 6 , 7 Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (495 mg) and potassium (720 mg). 8 Studies also document interest in production of HCA by using microorganisms. 9 , 10

Uses and Pharmacology

The medical literature primarily documents research on the weight loss and lipid-lowering activity of the plant.

In vitro and animal data

In 2 experiments using the human hepatoma cell line HepG2, overnight exposure to G. cambogia extract caused an upregulation of low-density lipoprotein (LDL) receptor activity and an upregulation of the level of HMG-CoA reductase resulting in decreased cholesterol synthesis. 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. 7 Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose-6-phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. cambogia extract maintained normal lipid levels in rats administered dexamethasone. 12

In a 4-week randomized, double-blind, placebo-controlled trial, 150 obese patients were treated with a dietary supplement ( G. cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg) together with a weight reduction regimen. Treatment groups administered the dietary supplement showed statistically significant dose-related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. 13

The suggested mechanism of action involves HCA-inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. 3 , 14

A study in obese rats found high doses of HCA-containing G. cambogia (154 mmol HCA/kg diet) effective in suppressing epididymal adipose tissue. This same study also found testicular atrophy and toxicity at dosages of 778 mg HCA/kg body weight/day (102 mmol HCA/kg diet) and higher. 4 Another study in rats administered a high-fat diet and a mixture of G. cambogia extract, soypeptide, and L-carnitine, led to a reduction in body weight and accumulation of visceral fat mass. 15 The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats.

I was 150 lbs before pregnancy, weighed 210 lbs when I went into delivey.

Other combination products with G. cambogia are also effective in reducing weight gain and improving dyslipidemia, hyperinsulinemia, hyperleptinemia, and fatty liver in mice. 16 The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat-free mass or energy expenditure. 17

In an 8-week randomized clinical trial, 40 patients were given either placebo or G. cambogia extract (500 mg/capsule) by mouth before each meal. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. 2

In a 12-week, randomized, double-blind, placebo-controlled study, 40 obese patients were treated with a combination supplement containing G. cambogia 50 mg as well as a 1,200 calorie diet per day. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3.5 kg weight loss versus 1.2 kg on placebo, and a more than 85% reduction in fat loss in body composition measurements. The majority of the active group participants did not follow the diet regimen. 18

In a 12-week, double-blind, placebo-controlled, parallel group trial, 89 mildly overweight women were treated with a 1,200 kcal diet along with 2 caplets of G. cambogia 400 mg or matched placebo 3 times a day before each meal. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables. 14

Numerous studies document the safety profile of the calcium-potassium double salt of 60% HCA preparation (HCA-SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. 3 , 19 , 20 , 21 , 22 , 23

An 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA-SX in 54 overweight patients. The treatment group was administered a combination supplement containing G. cambogia 500 mg 3 times a day while the control group received the placebo. All patients were asked to maintain a low-fat diet and drink 64 oz of water per day. The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person. 19

Another 8-week, randomized, placebo-controlled, double-blind study examined the efficacy of HCA in 60 obese patients. The dosage regimen for HCA was 400 mg 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group. 19

Visceral, subcutaneous, and total fat accumulation were reduced in 39 patients over 16 weeks in a double-blind, randomized, placebo-controlled trial. The dosage regimen included HCA 1,000 mg/day versus placebo. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. 24

Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. 25 However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. 2

Other pharmacologic activity

Some studies found that supplementation with G. cambogia can reduce oxidative damage. 26

The fruit contains xanthones, which inhibit pre-neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. 27

Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. cambogia . Leptin is a hormone associated with appetite control. G. cambogia may have leptin-like activity as mice treated with G. cambogia had decreased serum leptin levels and a reduced leptin/white adipose tissue ratio. 28 HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. 29

HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. 30 The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. 31 , 32

Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. cambogia extract that decreased volume and acidity of gastric juice. 33 A similar study in rats found activity against indomethacin-induced gastric ulcers. 34 The anti-inflammatory activity of G. cambogia protected against induced colitis in rats. 35

Red blood cell count

A G. cambogia extract caused an increase in the red blood cell (RBC) count in rat tissue. The activity may be (1) associated with the iron in G. cambogia , as iron is an erythropoietic agent; (2) antioxidant activity and may decrease the rate of oxidant-induced hemolysis, which increases the life span of the RBC; or (3) the content of bioflavonoids in the plant, which may increase the level of peripheral testosterone, which can stimulate erythropoiesis in humans. 36

The dosages of G. cambogia extract in clinical trials ranged from 1,500 to 4,667 mg/day (25 to 78 mg/kg/day). The equivalent HCA dose in the trials ranged from 900 to 2,800 mg/day (15 to 47 mg/kg/day). 2 , 14 , 18 , 19 , 23 , 24 , 25 G. cambogia is available in capsule or tablet form with a maximum dose of 1,500 mg/day.

Pregnancy/Lactation

Due to lack of clinical and scientific information, use should be avoided during pregnancy and lactation.

Conclusive research has not shown complete weight loss in some studies, but in others, they have shown effectiveness in weight loss.

One animal study in rats documented decreased maternal body weight gain during gestation. 37

Interactions

In patients taking medications for diabetes by mouth or insulin, G. cambogia may lower blood sugar levels. 28 , 29

G. cambogia contains iron and thus may have additive adverse reactions for patients taking medications for anemia. 36

Potassium and calcium supplements

Some commercial G. cambogia products contain adequate amounts of potassium and calcium. 8 Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb.

A mouse study using a commercial polyherbal product containing G. cambogia found a potential serotonergic effect on food intake. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. 38

Singulair (or leukotriene receptor antagonists)

One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. cambogia and citrus derivatives. 39

A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. cambogia . 40

In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. cambogia . 41

Adverse Reactions

A total of 15 clinical studies involving approximately 900 patients documented very mild adverse reactions. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. 2 , 42

Toxicology

Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,000 mg/kg, equivalent to 350 g or 233 times the maximum dose of 1.5 g/day of HCA. 5 In patients taking certain combination weight-loss supplements containing G. cambogia , severe or even fatal hepatotoxicity may occur. 43 , 44 Some animal studies document testicular toxicity, 4 , 45 while other studies do not. 46 , 47

No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. cambogia . 48 Patients receiving G. cambogia extract (1,667.3 mg/kg equivalent to 1,000 mg HCA/day) for 12 weeks exhibited no reproductive toxicity on serum testosterone, estrone, and estradiol levels. 49

Bibliography

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3. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

4. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol . 2005;43(3):411-419.

5. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia . J Agric Food Chem . 2002;50(1):10-22.

6. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia . J Agric Food Chem . 2008;56(13):5205-5210.

7. Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem . 2001;72(3):289-294.

8. Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mutat Res . 2005;579(1-2):149-162.

9. Hida H, Yamada T, Yamada Y. Production of hydroxycitric acid by microorganisms. Biosci Biotechnol Biochem . 2005;69(8):1555-1561.

10. Yamada T, Hida H, Yamada Y. Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol . 2007;75(5):977-982.

11. Berkhout TA, Havekes LM, Pearce NJ, Groot PH. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2. Biochem J . 1990;272(1):181-186.

12. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol . 2001;45(3):345-350.

13. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

14. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

15. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T. A mixture of the aqueous extract of Garcinia cambogia , soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr . 2008;2(4):353-358.

16. Kim KY, Lee HN, Kim YJ, Park T. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem . 2008;72(7):1772-1780.

17. Leray V, Dumon H, Martin L, et al. No effect of conjugated linoleic acid or Garcinia cambogia on fat-free mass, and energy expenditure in normal cats. J Nutr . 2006;136(suppl 7):1982S-1984S.

18. Thom E.

Just like with the capsule form, you should not eat or drink anything for 15 minutes after ingesting Garcinia cambogia in order to enhance bioavailability.

A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

19. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

20. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

21. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

22. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

23. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.

24. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

25. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA . 1998;280(18):1596-1600.

26. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

27. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res . 2009;23(3):385-398.

28. Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia . 2003;74(3):267-273.

29. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol . 2005;288(6):G1144-G1149.

30. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T. Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr . 2000;130(12):2990-2995.

31. Hoffman JR, Kang J, Ratamess NA, Jennings PF, Mangine G, Faigenbaum AD. Thermogenic effect from nutritionally enriched coffee consumption. J Int Soc Sports Nutr . 2006;3:35-41.

32. Taylor LW, Wilborn CD, Harvey T, Wismann J, Willoughby DS. Acute effects of ingesting Java Fittrade mark energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers. J Int Soc Sports Nutr . 2007;4:10.

33. Mahendran P, Sabitha KE, Devi CS. Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol . 2002;40(1):58-62.

34. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res . 2002;16(1):80-83.

35. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res . 2009;23(3):324-329.

36. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem . 2007;46(pt 1):69-72.

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